FCVB 2016:他汀类药物能降低常见癌症的死亡率吗?

2016-07-09 Mechront 译 MedSci原创

根据Frontiers in CardioVascular Biology (FCVB) 2016的研究,使用他汀类药物可降低肺癌、乳腺癌、前列腺癌和肠癌相关死亡率,并改善生存。这项为期14年的研究,包括了近100万名患者,发现高胆固醇的诊断与这四种常见癌症更低的死亡风险有关。英国伯明翰阿斯顿大学的Dr. Paul Carter说:“肥胖和高胆固醇作为癌症的危险因素,发现其之间的联系是令人兴奋的,

根据Frontiers in CardioVascular Biology (FCVB) 2016的研究,使用他汀类药物可降低肺癌、乳腺癌、前列腺癌和肠癌相关死亡率,并改善生存。

这项为期14年的研究,包括了近100万名患者,发现高胆固醇的诊断与这四种常见癌症更低的死亡风险有关。

英国伯明翰阿斯顿大学的Dr. Paul Carter说:“肥胖和高胆固醇作为癌症的危险因素,发现其之间的联系是令人兴奋的,如果高胆固醇可以导致癌症,那么降胆固醇治疗如他汀类药物就有可能降低这种风险。”

“先前我们的研究发现,高胆固醇和乳腺癌发展之间存在联系。动物研究表明,针对高胆固醇予以他汀类药物可以降低乳腺癌的风险。我们想看看他汀类药物是否对有高胆固醇的癌症患者也有用。”

因此研究者对英国的四个最常见的癌症:肺癌、乳腺癌,前列腺癌和肠癌进行了调查。

ACALM研究共有929552例患者,7997例肺癌,5481例乳腺癌,4629例前列腺癌,4570例肠癌。

校正年龄、性别和种族等可能影响死亡率的因素后,研究者发现,有一个高胆固醇的诊断患者相比没有此诊断的患者,死亡率更低。

诊断高胆固醇的肺癌患者其死亡风险降低了22%,乳腺癌死亡风险降低了43%,前列腺癌死亡风险降低了47%,肠癌死亡风险降低了30%。

“我们的研究表明,高胆固醇的诊断能提高癌症患者的生存。根据以前的研究,我们认为他汀类药物在这之间的联系中功不可没。”

Dr. Carter继续说,他们认为该作用是由治疗高胆固醇的药物如他汀类药物引起的。然而,需要对其他类型的癌症进行研究,以证实这一猜测。

原始出处:


Statins: could they decrease death risk in four most common cancers?MNT.9 July 2016.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2044413, encodeId=9c5e204441382, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Thu Mar 23 08:26:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=132035, encodeId=cba3132035aa, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 21 08:17:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125702, encodeId=c3a5125e0206, content=他汀类药物的疗效竟然如此强大,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 20:47:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93067, encodeId=84a19306e49, content=学习一下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54221735253, createdName=1def88e4m69(暂无匿称), createdTime=Thu Jul 14 14:16:00 CST 2016, time=2016-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92812, encodeId=a3d392812bc, content=学习一下吧!, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKoIvWhsa7vftKa8HRtgKXnq0PXQJH7D08eiau0n0TQkw4hj9UmTaSGfnm7HHVPVhNwIs37Dyia5xtQ/132, createdBy=e1ac1653865, createdName=1ddd30d9m35(暂无匿称), createdTime=Tue Jul 12 08:39:00 CST 2016, time=2016-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92554, encodeId=8f8a925545b, content=他丁类加入癌症治疗中, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Jul 10 10:52:00 CST 2016, time=2016-07-10, status=1, ipAttribution=)]
    2016-09-21 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

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    2016-09-13 舒心和人

    他汀类药物的疗效竟然如此强大,学习了

    0

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    2016-07-14 1def88e4m69(暂无匿称)

    学习一下吧

    0

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    2016-07-12 1ddd30d9m35(暂无匿称)

    学习一下吧!

    0

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    2016-07-10 oo902

    他丁类加入癌症治疗中

    0

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