JACC:BAV或MVP感染性心内膜炎:到底是否需抗生素预防?

2018-07-20 吴星 环球医学

关于二尖瓣主动脉瓣(BAV)或二尖瓣脱垂(MVP)患者感染性心内膜炎(IE)的信息很少。目前,不推荐感染性心内膜炎抗生素预防(IEAP)用于这些病症。2018年6月,发表在《J Am Coll Cardiol》的一项研究描述BAV和MVP患者IE的临床和微生物学特征,并将其与合并或不合并IEAP指征的IE患者进行比较,以确定IEAP在这些疾病中的潜在益处。

关于二尖瓣主动脉瓣(BAV)或二尖瓣脱垂(MVP)患者感染性心内膜炎(IE)的信息很少。目前,不推荐感染性心内膜炎抗生素预防(IEAP)用于这些病症。2018年6月,发表在《J Am Coll Cardiol》的一项研究描述BAV和MVP患者IE的临床和微生物学特征,并将其与合并或不合并IEAP指征的IE患者进行比较,以确定IEAP在这些疾病中的潜在益处。

目的:本研究旨在描述BAV和MVP患者IE的临床和微生物学特征,并将其与合并或不合并IEAP指征的IE患者进行比较,以确定IEAP在这些疾病中的潜在益处。

方法:该分析涉及西班牙31家医院GAMES (Grupo de Apoyo al Manejo de la Endocarditis infecciosa en Espa?a)注册中前瞻性纳入的3208例连续的IE患者。患者被分层为高风险IE合并IEAP指征(高风险;1226例)、低风险和中度风险IE不合并IEAP指征(低/中度风险组;1839例),以及IE合并BAV(54例)或MVP(89例)。

结果:BAV和MVP患者的草绿色链球菌IE发病率高于高风险组和低/中度风险组(分别为35.2%和39.3% vs 12.1%和15.0%;均p<0.01)。疑似牙源性IE的发病率也是如此(14.8%和18.0% vs 5.8%和6.0%;均p<0.01)。BAV和MVP患者的心脏内并发症多于低/中度风险组患者(50% 和47.2% vs 30.6%,均p<0.01),与高风险组患者相似。

结论:与其他IE患者相比,BAV和MVP患者的IE具有较高的草绿色链球菌IE和牙源性可疑病因,其临床特征与高风险IE患者相似。该研究结果表明,BAV和MVP应归类为高风险的IE疾病,应重新考虑IEAP的情况。

原始出处:

Zegri-Reiriz I, et al. Infective Endocarditis in Patients With Bicuspid Aortic Valve or Mitral Valve Prolapse. J Am Coll Cardiol. 2018 Jun 19;71(24):2731-2740. doi: 10.1016/j.jacc.2018.03.534.

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    2019-02-27 hbwxf
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