JAMA:荟萃分析证实抑郁升高卒中危险

2011-10-09 MedSci原创 MedSci原创

  有些研究提示抑郁可升高卒中危险,但结果并不一致。近日,美国研究者在《美国医学会杂志》[JAMA.2011:306(11):1241-1249]发表了一项荟萃分析和系统性评价证实,抑郁与卒中发病率和死亡率危险显著升高相关。   该分析纳入了近些卒中发病率和死亡率危险评估的28项前瞻性队列研究,包含317540位受试者,在随访2~29年间,共报告了8478例卒中病例。结果表明,汇总校正的总的卒中

  有些研究提示抑郁可升高卒中危险,但结果并不一致。近日,美国研究者在《美国医学会杂志》[JAMA.2011:306(11):1241-1249]发表了一项荟萃分析和系统性评价证实,抑郁与卒中发病率和死亡率危险显著升高相关。

  该分析纳入了近些卒中发病率和死亡率危险评估的28项前瞻性队列研究,包含317540位受试者,在随访2~29年间,共报告了8478例卒中病例。结果表明,汇总校正的总的卒中风险比(HR)为1.45,致死性卒中为1.55,缺血性卒中为1.25。估计的与抑郁有关的绝对风险差异为:所有卒中 106例/(10万例·年)、缺血性卒中53例/(10万例·年)、致死性卒中22例/(10万例·年)。在多数亚组中,与抑郁相关的所有卒中危险升高结果一致。

  链接:

  Depression and Risk of Stroke Morbidity and Mortality

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    2011-10-20 159.220.30.191

    In the complicated world we live in, it's good to find simple soulitons.

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