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Theranostics：绿升麻提取物可抑制三阴性乳腺癌

2016-05-02 MedSci MedSci原创

升麻乳腺癌
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中科院的科学家通过研究发现，中药绿升麻的提取物具有抑制三阴性乳腺癌的作用，该项研究成果已于近日发表在国际期刊《治疗与诊断学》上。三阴性乳腺癌是一种最为恶性的乳腺癌类型，目前对其治疗还停留在传统的化疗水平，患者在治疗后复发率高，并且癌细胞容易转移，急需寻找新的治疗靶点和有效药物来提高三阴性乳腺癌患者的生存率。毛茛科升麻属植物在我国是著名的常用中药，其药用价值早在《神农本草经》中就有记载，其地下根茎入

中科院的科学家通过研究发现，中药绿升麻的提取物具有抑制三阴性乳腺癌的作用，该项研究成果已于近日发表在国际期刊《治疗与诊断学》上。

三阴性乳腺癌是一种最为恶性的乳腺癌类型，目前对其治疗还停留在传统的化疗水平，患者在治疗后复发率高，并且癌细胞容易转移，急需寻找新的治疗靶点和有效药物来提高三阴性乳腺癌患者的生存率。

毛茛科升麻属植物在我国是著名的常用中药，其药用价值早在《神农本草经》中就有记载，其地下根茎入药，功效为清热解毒，民间用它治疗咽喉肿痛、牙痛和妇科疾病。近年来研究表明，升麻中提取的三萜类化合物具有抗肿瘤、抗疟疾、降血脂等方面的生物活性。

绿升麻是升麻中的一种。中科院昆明动物研究所和中科院昆明植物研究所的科学家们通过联合研究，发现了绿升麻提取物对三阴性乳腺癌的抑癌机制。据论文第一作者，中科院昆明动物研究所肿瘤生物学学科组博士生孔燕杰介绍，研究人员从绿升麻的干燥块茎中分离纯化出大量三萜类单体化合物，通过筛选，发现活性化合物KHF16 (24-acetylisodahurinol-3-O-β-D-xylopyranoside)能够显著抑制三阴性乳腺癌细胞系的体外存活。进一步研究发现，KHF16部分通过抑制三阴性乳腺癌细胞增殖和存活相关信号通路，来诱导癌细胞的凋亡和周期阻滞、降低耐药蛋白的表达水平，从而达到抑制癌细胞增殖的效果。

进一步研究发现，KHF16能够显著诱导MDA-MB-468和SW527的细胞增殖，将癌细胞的细胞周期阻滞在G2/M期，同时诱导细胞凋亡。KHF16能降低XIAP、Mcl-1、Survivin和 Cyclin B1/D1等蛋白的表达水平。机制研究发现KHF16抑制TNBC细胞中NF-κB信号通路。KHF16强烈阻断IKKα/β和IKBα磷酸化，p65入核以及NF-κB下游靶基因包括XIAP，Mcl-1和Survivin的表达。

Theranostics:中科院昆明动物所陈策实研究组与植物所邱明华研究组合作发现升麻提取物抑制三阴


“我们在研究中还发现，绿升麻提取物KHF16对于胃癌、肝癌和骨肉瘤同样有抑制效果，由此可见，从中国传统药用植物中分离和筛选出诱导癌细胞凋亡的单体成分，将为研发新的抗肿瘤药物奠定重要基础。”孔燕杰说。

同时，小编也检索发现，他们研究组在2014年也发表过前期研究结果，绿升麻中Cucurbitacin E能诱导三阴性乳腺癌细胞出现增殖抑制，发表在PLoS One上。

原始出处：
Yanjie Kong; Fubin Li; Yin Nian; Zhongmei Zhou; Runxiang Yang*; Ming-Hua Qiu*; Ceshi Chen. KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway. Theranostics,2016, 6(6):875-886

Kong Y, Chen J, Zhou Z, Xia H, Qiu MH, Chen C. Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer. PLoS One. 2014 Jul 29;9(7):e103760.

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    2016-09-04 ylzr123

    赞！好文章，拜读，值得深入学习！

    0

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    2016-09-07 circumcision

    #阴性乳腺癌#

    0

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authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Sat May 14 21:46:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85174, encodeId=435c851e41a, content=学习了，很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85175, encodeId=b1dc851e51f, content=真的不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85176, encodeId=99e4851e6b3, content=真的不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049875, encodeId=28f620498e5f4, content=<a href='/topic/show?id=852b1e3838b' target=_blank style='color:#2F92EE;'>#Theranos#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17383, encryptionId=852b1e3838b, topicName=Theranos)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3289320, createdName=海豹, createdTime=Tue Sep 13 16:32:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-07-31 tinali1986

    升麻又成了一味神奇的药物

    0

  4. 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createdName=circumcision, createdTime=Wed Sep 07 07:32:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95349, encodeId=235d95349b7, content=升麻又成了一味神奇的药物, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJDLicbdiao8d0vymSicFv4hYM7xuBbl2k4kA5oxnVBXkmQzoFZOK07PnLKAS9KGeoxOIM3uBWN0ZQhA/132, createdBy=86ba1929521, createdName=tinali1986, createdTime=Sun Jul 31 22:20:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738784, encodeId=1bb51e38784eb, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Tue Aug 02 14:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85758, encodeId=674585e587b, content=学习了。我们也试过得得得, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Sat May 14 21:47:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85757, encodeId=3f4285e57d6, content=学习了。我们也试过得得得, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Sat May 14 21:46:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85174, encodeId=435c851e41a, content=学习了，很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85175, encodeId=b1dc851e51f, content=真的不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85176, encodeId=99e4851e6b3, content=真的不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049875, encodeId=28f620498e5f4, content=<a href='/topic/show?id=852b1e3838b' target=_blank style='color:#2F92EE;'>#Theranos#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17383, encryptionId=852b1e3838b, topicName=Theranos)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3289320, createdName=海豹, createdTime=Tue Sep 13 16:32:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-08-02 124988c7m106暂无昵称

    #ERA#

    0

  5. 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authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Sat May 14 21:46:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85174, encodeId=435c851e41a, content=学习了，很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85175, encodeId=b1dc851e51f, content=真的不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85176, encodeId=99e4851e6b3, content=真的不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049875, encodeId=28f620498e5f4, content=<a href='/topic/show?id=852b1e3838b' target=_blank style='color:#2F92EE;'>#Theranos#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17383, encryptionId=852b1e3838b, topicName=Theranos)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3289320, createdName=海豹, createdTime=Tue Sep 13 16:32:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-05-14 qian0416

    学习了。我们也试过得得得

    0

  6. 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encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Tue Aug 02 14:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85758, encodeId=674585e587b, content=学习了。我们也试过得得得, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Sat May 14 21:47:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85757, encodeId=3f4285e57d6, content=学习了。我们也试过得得得, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Sat May 14 21:46:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85174, encodeId=435c851e41a, content=学习了，很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85175, encodeId=b1dc851e51f, content=真的不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85176, encodeId=99e4851e6b3, content=真的不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049875, encodeId=28f620498e5f4, content=<a href='/topic/show?id=852b1e3838b' target=_blank style='color:#2F92EE;'>#Theranos#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17383, encryptionId=852b1e3838b, topicName=Theranos)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3289320, createdName=海豹, createdTime=Tue Sep 13 16:32:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-05-14 qian0416

    学习了。我们也试过得得得

    0

  7. 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createdName=circumcision, createdTime=Wed Sep 07 07:32:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95349, encodeId=235d95349b7, content=升麻又成了一味神奇的药物, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJDLicbdiao8d0vymSicFv4hYM7xuBbl2k4kA5oxnVBXkmQzoFZOK07PnLKAS9KGeoxOIM3uBWN0ZQhA/132, createdBy=86ba1929521, createdName=tinali1986, createdTime=Sun Jul 31 22:20:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738784, encodeId=1bb51e38784eb, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Tue Aug 02 14:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85758, encodeId=674585e587b, content=学习了。我们也试过得得得, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Sat May 14 21:47:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85757, encodeId=3f4285e57d6, content=学习了。我们也试过得得得, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Sat May 14 21:46:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85174, encodeId=435c851e41a, content=学习了，很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85175, encodeId=b1dc851e51f, content=真的不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85176, encodeId=99e4851e6b3, content=真的不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049875, encodeId=28f620498e5f4, content=<a href='/topic/show?id=852b1e3838b' target=_blank style='color:#2F92EE;'>#Theranos#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17383, encryptionId=852b1e3838b, topicName=Theranos)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3289320, createdName=海豹, createdTime=Tue Sep 13 16:32:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-05-09 stead

    学习了，很好的

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=110860, encodeId=4aed11086052, content=赞！好文章，拜读，值得深入学习！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 04 15:06:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047939, encodeId=f408204e9397a, content=<a href='/topic/show?id=12e49e53102' target=_blank style='color:#2F92EE;'>#阴性乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97531, encryptionId=12e49e53102, topicName=阴性乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Wed Sep 07 07:32:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95349, encodeId=235d95349b7, content=升麻又成了一味神奇的药物, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJDLicbdiao8d0vymSicFv4hYM7xuBbl2k4kA5oxnVBXkmQzoFZOK07PnLKAS9KGeoxOIM3uBWN0ZQhA/132, createdBy=86ba1929521, createdName=tinali1986, createdTime=Sun Jul 31 22:20:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738784, encodeId=1bb51e38784eb, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Tue Aug 02 14:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85758, encodeId=674585e587b, content=学习了。我们也试过得得得, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Sat May 14 21:47:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85757, encodeId=3f4285e57d6, content=学习了。我们也试过得得得, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Sat May 14 21:46:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85174, encodeId=435c851e41a, content=学习了，很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85175, encodeId=b1dc851e51f, content=真的不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85176, encodeId=99e4851e6b3, content=真的不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049875, encodeId=28f620498e5f4, content=<a href='/topic/show?id=852b1e3838b' target=_blank style='color:#2F92EE;'>#Theranos#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17383, encryptionId=852b1e3838b, topicName=Theranos)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3289320, createdName=海豹, createdTime=Tue Sep 13 16:32:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-05-09 stead

    真的不错啊

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=110860, encodeId=4aed11086052, content=赞！好文章，拜读，值得深入学习！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 04 15:06:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047939, encodeId=f408204e9397a, content=<a href='/topic/show?id=12e49e53102' target=_blank style='color:#2F92EE;'>#阴性乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97531, encryptionId=12e49e53102, topicName=阴性乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Wed Sep 07 07:32:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95349, encodeId=235d95349b7, content=升麻又成了一味神奇的药物, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJDLicbdiao8d0vymSicFv4hYM7xuBbl2k4kA5oxnVBXkmQzoFZOK07PnLKAS9KGeoxOIM3uBWN0ZQhA/132, createdBy=86ba1929521, createdName=tinali1986, createdTime=Sun Jul 31 22:20:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738784, encodeId=1bb51e38784eb, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Tue Aug 02 14:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85758, encodeId=674585e587b, content=学习了。我们也试过得得得, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Sat May 14 21:47:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85757, encodeId=3f4285e57d6, content=学习了。我们也试过得得得, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Sat May 14 21:46:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85174, encodeId=435c851e41a, content=学习了，很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85175, encodeId=b1dc851e51f, content=真的不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85176, encodeId=99e4851e6b3, content=真的不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049875, encodeId=28f620498e5f4, content=<a href='/topic/show?id=852b1e3838b' target=_blank style='color:#2F92EE;'>#Theranos#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17383, encryptionId=852b1e3838b, topicName=Theranos)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3289320, createdName=海豹, createdTime=Tue Sep 13 16:32:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-05-09 stead

    真的不错

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=110860, encodeId=4aed11086052, content=赞！好文章，拜读，值得深入学习！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 04 15:06:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047939, encodeId=f408204e9397a, content=<a href='/topic/show?id=12e49e53102' target=_blank style='color:#2F92EE;'>#阴性乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97531, encryptionId=12e49e53102, topicName=阴性乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Wed Sep 07 07:32:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95349, encodeId=235d95349b7, content=升麻又成了一味神奇的药物, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJDLicbdiao8d0vymSicFv4hYM7xuBbl2k4kA5oxnVBXkmQzoFZOK07PnLKAS9KGeoxOIM3uBWN0ZQhA/132, createdBy=86ba1929521, createdName=tinali1986, createdTime=Sun Jul 31 22:20:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738784, encodeId=1bb51e38784eb, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Tue Aug 02 14:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85758, encodeId=674585e587b, content=学习了。我们也试过得得得, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Sat May 14 21:47:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85757, encodeId=3f4285e57d6, content=学习了。我们也试过得得得, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Sat May 14 21:46:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85174, encodeId=435c851e41a, content=学习了，很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85175, encodeId=b1dc851e51f, content=真的不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85176, encodeId=99e4851e6b3, content=真的不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 23:46:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049875, encodeId=28f620498e5f4, content=<a href='/topic/show?id=852b1e3838b' target=_blank style='color:#2F92EE;'>#Theranos#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17383, encryptionId=852b1e3838b, topicName=Theranos)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3289320, createdName=海豹, createdTime=Tue Sep 13 16:32:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-13 海豹

    #Theranos#

    0

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