Neurology:年轻脑卒中患者导致脑小血管病变发展加速

2016-09-25 MedSci MedSci原创

研究结果表明,年轻的卒中患者更容易发生小血管疾病,可能因为血管危险因素的增加,这些患者大脑老化似乎加速了10 - 20年。

近日,神经病学领域权威杂志《neurology》上发表文章旨在明确年轻脑卒中患者长期小血管疾病发病率。

研究者采用前瞻性队列研究的方法,纳入337例缺血性中风或短暂性脑缺血发作研究对象,研究对象之前缺血性中风或短暂性脑缺血发作病史,年龄在18岁–50岁之间。此外,90个年龄和性别匹配的健康者作为对照组。在随访中,腔隙、微小出血、白质高信号用磁共振来进行评估。研究者采用逻辑回归和线性回归来探讨危险因素与小血管病的关系。

研究者在平均随访9.9年(标准差为 8.1年)中,在337例患者中,227例发生缺血性脑卒中,110例发生短暂性脑缺血发作。患者平均年龄为49.8岁(标准差10.3岁),45.4%为男性;对照组平均年龄为49.4岁(标准差11.9岁),男性占45.6%。


与对照组相比,患者至少有1个腔隙(24% vs 4.5%,P<0.0001)。此外,他们有较高的白质高信号体积(平均1.5 mL [四分位数间距(IQR)0.5–3.7 ]与0.4mL [四分位数间距(IQR)0.0–1.0],P<0.001)。

与对照组相比,患者有相同的白质高信号体积,并且平均早10–20年。在患者组中,脑卒中的年龄(β=0.03,95%可信区间为0.02–0.04)、高血压(β=0.22,95% 可信区间0.04–0.39)和吸烟(β=0.18,95% 可信区间0.01–0.34)与白质高信号体积有关。

研究结果表明,年轻的卒中患者更容易发生小血管疾病,可能因为血管危险因素的增加,这些患者大脑老化似乎加速了10 - 20年。

原始出处:

Renate M. Arntz, et al. Accelerated development of cerebral small vessel disease in young stroke patients. Neurology 2016.

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    2017-05-26 yinhl1978
  6. [GetPortalCommentsPageByObjectIdResponse(id=1715826, encodeId=09311e15826fb, content=<a href='/topic/show?id=441b4e17253' target=_blank style='color:#2F92EE;'>#小血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47172, encryptionId=441b4e17253, topicName=小血管病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Oct 12 17:20:00 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1644504, encodeId=bfcd164450400, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Aug 21 13:20:00 CST 2017, time=2017-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679075, encodeId=cf4d16e907579, content=<a href='/topic/show?id=7a2684e600b' target=_blank style='color:#2F92EE;'>#脑卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84760, encryptionId=7a2684e600b, topicName=脑卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=091e27733095, createdName=weihongyv, createdTime=Tue May 16 08:20:00 CST 2017, time=2017-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720129, encodeId=a8601e20129ff, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Sat Jan 07 00:20:00 CST 2017, time=2017-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999749, encodeId=95df1999e49dd, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri May 26 22:20:00 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138953, encodeId=d0f6138953a2, content=很好,有帮助,很喜欢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160930/IMG57EDFF4739EBF3035.jpg, createdBy=0da11618734, createdName=右脚梅西, createdTime=Sun Oct 02 11:50:09 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138951, encodeId=a6c7138951e8, content=很好,有帮助,很喜欢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160930/IMG57EDFF4739EBF3035.jpg, createdBy=0da11618734, createdName=右脚梅西, createdTime=Sun Oct 02 11:49:53 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304249, encodeId=fdc213042498e, content=<a href='/topic/show?id=87068482845' target=_blank style='color:#2F92EE;'>#脑小血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84828, encryptionId=87068482845, topicName=脑小血管病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68f2317, createdName=天堂的云, createdTime=Tue Sep 27 13:20:00 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391058, encodeId=8af21391058af, content=<a href='/topic/show?id=6d0689e19f0' target=_blank style='color:#2F92EE;'>#血管病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89719, encryptionId=6d0689e19f0, topicName=血管病变)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85152500072, createdName=124987c6m36暂无昵称, createdTime=Tue Sep 27 13:20:00 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
    2016-10-02 右脚梅西

    很好,有帮助,很喜欢。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1715826, encodeId=09311e15826fb, content=<a href='/topic/show?id=441b4e17253' target=_blank style='color:#2F92EE;'>#小血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47172, encryptionId=441b4e17253, topicName=小血管病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Oct 12 17:20:00 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1644504, encodeId=bfcd164450400, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Aug 21 13:20:00 CST 2017, time=2017-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679075, encodeId=cf4d16e907579, content=<a href='/topic/show?id=7a2684e600b' target=_blank style='color:#2F92EE;'>#脑卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84760, encryptionId=7a2684e600b, topicName=脑卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=091e27733095, createdName=weihongyv, createdTime=Tue May 16 08:20:00 CST 2017, time=2017-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720129, encodeId=a8601e20129ff, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Sat Jan 07 00:20:00 CST 2017, time=2017-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999749, encodeId=95df1999e49dd, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri May 26 22:20:00 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138953, encodeId=d0f6138953a2, content=很好,有帮助,很喜欢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160930/IMG57EDFF4739EBF3035.jpg, createdBy=0da11618734, createdName=右脚梅西, createdTime=Sun Oct 02 11:50:09 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138951, encodeId=a6c7138951e8, content=很好,有帮助,很喜欢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160930/IMG57EDFF4739EBF3035.jpg, createdBy=0da11618734, createdName=右脚梅西, createdTime=Sun Oct 02 11:49:53 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304249, encodeId=fdc213042498e, content=<a href='/topic/show?id=87068482845' target=_blank style='color:#2F92EE;'>#脑小血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84828, encryptionId=87068482845, topicName=脑小血管病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68f2317, createdName=天堂的云, createdTime=Tue Sep 27 13:20:00 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391058, encodeId=8af21391058af, content=<a href='/topic/show?id=6d0689e19f0' target=_blank style='color:#2F92EE;'>#血管病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89719, encryptionId=6d0689e19f0, topicName=血管病变)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85152500072, createdName=124987c6m36暂无昵称, createdTime=Tue Sep 27 13:20:00 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
    2016-10-02 右脚梅西

    很好,有帮助,很喜欢。

    0

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