NRR:淫羊藿甙局部给药可促进周围神经再生及功能恢复

2015-03-19 赵萌 《中国神经再生研究(英文版)》杂志

来自中国北京大学人民医院和北京大学交通医学中心的姜保国博士所领导的团队前期,进行的动物实验证实,传统中药淫羊藿提取液全身给药具有促周围神经再生的作用。本文希望进一步明确单体淫羊藿甙局部给药对周围神经再生的修复效果。实验用聚乳酸-羟基乙酸共聚物生物套管套接大鼠右侧坐骨神经5mm缺损,然后向套接间隙内分别注入生理盐水、神经生长因子水溶液、淫羊藿甙混悬液、神经生长因子缓释微球混悬液。12周后,与神经

来自中国北京大学人民医院和北京大学交通医学中心的姜保国博士所领导的团队前期,进行的动物实验证实,传统中药淫羊藿提取液全身给药具有促周围神经再生的作用。本文希望进一步明确单体淫羊藿甙局部给药对周围神经再生的修复效果。实验用聚乳酸-羟基乙酸共聚物生物套管套接大鼠右侧坐骨神经5mm缺损,然后向套接间隙内分别注入生理盐水、神经生长因子水溶液、淫羊藿甙混悬液、神经生长因子缓释微球混悬液。12周后,与神经生长因子水溶液和生理盐水治疗的大鼠相比,淫羊藿甙混悬液治疗的大鼠坐骨神经功能指数、小腿三头肌肌肉湿质量恢复率、三头肌肌肉组织形态未见明显变化,而坐骨神经传导速度及有髓神经纤维数量明显增加,且效果与神经生长因子缓释微球接近。说明淫羊藿甙局部应用与促神经再生的神经生长因子作用一样能促进周围神经再生。相关文献发表于《中国神经再生研究(英文版)》杂志2015年1月第1期。

原始出处

Chen B, Niu Sp, Wang Zy, Wang Zw, Deng Jx, Zhang Px, Yin Xf, Han N, Kou Yh, Jiang Bg. Local administration of icariin contributes to peripheral nerve regeneration and functional recovery. Neural Regen Res 2015 ;10:84-9. Available from: http://www.nrronline.org/text.asp?2015/10/1/84/150711

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    2017-09-10 心欲无痕 无欲则刚

    如果缺损的神经大于5mm,淫羊藿甙任然有用吗?

    0

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    2015-03-21 chg122
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    2015-03-21 wenjie
  5. [GetPortalCommentsPageByObjectIdResponse(id=242506, encodeId=e3cd24250686, content=如果缺损的神经大于5mm,淫羊藿甙任然有用吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/23/e8940e6c852aed5b3336028f3dd5ff43.jpg, createdBy=f15f2091876, createdName=心欲无痕 无欲则刚, createdTime=Sun Sep 10 10:18:39 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748235, encodeId=50971e4823596, content=<a href='/topic/show?id=15b33952464' target=_blank style='color:#2F92EE;'>#周围神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39524, encryptionId=15b33952464, topicName=周围神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f00136108751, createdName=Smile2692, createdTime=Tue Sep 29 18:33:00 CST 2015, time=2015-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405673, encodeId=301714056e35a, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510567, encodeId=8cd4151056ee7, content=<a href='/topic/show?id=7400660665b' target=_blank style='color:#2F92EE;'>#淫羊藿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66066, encryptionId=7400660665b, topicName=淫羊藿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e0810213212, createdName=wenjie, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523770, encodeId=1b3f1523e7025, content=<a href='/topic/show?id=1c43e421182' target=_blank style='color:#2F92EE;'>#神经再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74211, encryptionId=1c43e421182, topicName=神经再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b0211549475, createdName=hxj0121, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599321, encodeId=39461599321b7, content=<a href='/topic/show?id=5eb4329159a' target=_blank style='color:#2F92EE;'>#功能恢复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32915, encryptionId=5eb4329159a, topicName=功能恢复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e9518693674, createdName=mnda, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18560, encodeId=025b18560f3, content=希望, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CRAZYDAFF, createdTime=Fri Mar 20 08:57:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18517, encodeId=5c171851e21, content=真的可以吗我家小孩脑外伤我一直在关注神经方面的信息,希望能得到你们的帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76831609361, createdName=496426759, createdTime=Thu Mar 19 19:30:00 CST 2015, time=2015-03-19, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=242506, encodeId=e3cd24250686, content=如果缺损的神经大于5mm,淫羊藿甙任然有用吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/23/e8940e6c852aed5b3336028f3dd5ff43.jpg, createdBy=f15f2091876, createdName=心欲无痕 无欲则刚, createdTime=Sun Sep 10 10:18:39 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748235, encodeId=50971e4823596, content=<a href='/topic/show?id=15b33952464' target=_blank style='color:#2F92EE;'>#周围神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39524, encryptionId=15b33952464, topicName=周围神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f00136108751, createdName=Smile2692, createdTime=Tue Sep 29 18:33:00 CST 2015, time=2015-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405673, encodeId=301714056e35a, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510567, encodeId=8cd4151056ee7, content=<a href='/topic/show?id=7400660665b' target=_blank style='color:#2F92EE;'>#淫羊藿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66066, encryptionId=7400660665b, topicName=淫羊藿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e0810213212, createdName=wenjie, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523770, encodeId=1b3f1523e7025, content=<a href='/topic/show?id=1c43e421182' target=_blank style='color:#2F92EE;'>#神经再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74211, encryptionId=1c43e421182, topicName=神经再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b0211549475, createdName=hxj0121, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599321, encodeId=39461599321b7, content=<a href='/topic/show?id=5eb4329159a' target=_blank style='color:#2F92EE;'>#功能恢复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32915, encryptionId=5eb4329159a, topicName=功能恢复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e9518693674, createdName=mnda, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18560, encodeId=025b18560f3, content=希望, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CRAZYDAFF, createdTime=Fri Mar 20 08:57:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18517, encodeId=5c171851e21, content=真的可以吗我家小孩脑外伤我一直在关注神经方面的信息,希望能得到你们的帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76831609361, createdName=496426759, createdTime=Thu Mar 19 19:30:00 CST 2015, time=2015-03-19, status=1, ipAttribution=)]
    2015-03-21 mnda
  7. [GetPortalCommentsPageByObjectIdResponse(id=242506, encodeId=e3cd24250686, content=如果缺损的神经大于5mm,淫羊藿甙任然有用吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/23/e8940e6c852aed5b3336028f3dd5ff43.jpg, createdBy=f15f2091876, createdName=心欲无痕 无欲则刚, createdTime=Sun Sep 10 10:18:39 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748235, encodeId=50971e4823596, content=<a href='/topic/show?id=15b33952464' target=_blank style='color:#2F92EE;'>#周围神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39524, encryptionId=15b33952464, topicName=周围神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f00136108751, createdName=Smile2692, createdTime=Tue Sep 29 18:33:00 CST 2015, time=2015-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405673, encodeId=301714056e35a, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510567, encodeId=8cd4151056ee7, content=<a href='/topic/show?id=7400660665b' target=_blank style='color:#2F92EE;'>#淫羊藿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66066, encryptionId=7400660665b, topicName=淫羊藿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e0810213212, createdName=wenjie, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523770, encodeId=1b3f1523e7025, content=<a href='/topic/show?id=1c43e421182' target=_blank style='color:#2F92EE;'>#神经再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74211, encryptionId=1c43e421182, topicName=神经再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b0211549475, createdName=hxj0121, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599321, encodeId=39461599321b7, content=<a href='/topic/show?id=5eb4329159a' target=_blank style='color:#2F92EE;'>#功能恢复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32915, encryptionId=5eb4329159a, topicName=功能恢复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e9518693674, createdName=mnda, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18560, encodeId=025b18560f3, content=希望, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CRAZYDAFF, createdTime=Fri Mar 20 08:57:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18517, encodeId=5c171851e21, content=真的可以吗我家小孩脑外伤我一直在关注神经方面的信息,希望能得到你们的帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76831609361, createdName=496426759, createdTime=Thu Mar 19 19:30:00 CST 2015, time=2015-03-19, status=1, ipAttribution=)]
    2015-03-20 CRAZYDAFF

    希望

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=242506, encodeId=e3cd24250686, content=如果缺损的神经大于5mm,淫羊藿甙任然有用吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/23/e8940e6c852aed5b3336028f3dd5ff43.jpg, createdBy=f15f2091876, createdName=心欲无痕 无欲则刚, createdTime=Sun Sep 10 10:18:39 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748235, encodeId=50971e4823596, content=<a href='/topic/show?id=15b33952464' target=_blank style='color:#2F92EE;'>#周围神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39524, encryptionId=15b33952464, topicName=周围神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f00136108751, createdName=Smile2692, createdTime=Tue Sep 29 18:33:00 CST 2015, time=2015-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405673, encodeId=301714056e35a, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510567, encodeId=8cd4151056ee7, content=<a href='/topic/show?id=7400660665b' target=_blank style='color:#2F92EE;'>#淫羊藿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66066, encryptionId=7400660665b, topicName=淫羊藿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e0810213212, createdName=wenjie, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523770, encodeId=1b3f1523e7025, content=<a href='/topic/show?id=1c43e421182' target=_blank style='color:#2F92EE;'>#神经再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74211, encryptionId=1c43e421182, topicName=神经再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b0211549475, createdName=hxj0121, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599321, encodeId=39461599321b7, content=<a href='/topic/show?id=5eb4329159a' target=_blank style='color:#2F92EE;'>#功能恢复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32915, encryptionId=5eb4329159a, topicName=功能恢复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e9518693674, createdName=mnda, createdTime=Sat Mar 21 08:33:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18560, encodeId=025b18560f3, content=希望, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CRAZYDAFF, createdTime=Fri Mar 20 08:57:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18517, encodeId=5c171851e21, content=真的可以吗我家小孩脑外伤我一直在关注神经方面的信息,希望能得到你们的帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76831609361, createdName=496426759, createdTime=Thu Mar 19 19:30:00 CST 2015, time=2015-03-19, status=1, ipAttribution=)]
    2015-03-19 496426759

    真的可以吗我家小孩脑外伤我一直在关注神经方面的信息,希望能得到你们的帮助

    0