Alzheimer’s Dis:创伤后脑损伤增加认知功能障碍风险

2016-03-17 QQduhp 译 MedSci原创

有研究人员指出,创伤性脑损伤(TBI)会增加民众较早出现轻度认知障碍(MCI)的风险。基于他们的研究结果,研究人员指出,既往发生创伤性脑损伤(TBI)和失去意识超过5分钟的民众较早出现MCI的风险增加。德克萨斯大学C.Munro Cullum博士指出,这是第一个通过对较多民众进行探究后正式既往创伤性脑损伤病史增加民众晚年轻度认知障碍风险的研究。他们表示还不能确定发生TBI后哪类民众出现晚年认知功能

有研究人员指出,创伤性脑损伤(TBI)会增加民众较早出现轻度认知障碍(MCI)的风险。基于他们的研究结果,研究人员指出,既往发生创伤性脑损伤(TBI)和失去意识超过5分钟的民众较早出现MCI的风险增加。德克萨斯大学C.Munro Cullum博士指出,这是第一个通过对较多民众进行探究后正式既往创伤性脑损伤病史增加民众晚年轻度认知障碍风险的研究。他们表示还不能确定发生TBI后哪类民众出现晚年认知功能衰退的风险较大,但是这些结果表明,TBI与MCI之间存在某些关联,研究人员试图更深入进行探究其影响因素。 

Cullum博士和同事对3187名出现MCI的民众和3244名健康民众进行了探究。数据来源于国家阿尔茨海默症统计中心。数据库分析表明,发生创伤性脑损伤且失去意识超过5分钟的民众出现MCI的风险是未发生创伤性脑损伤的民众的1.2-1.3倍,出现认知障碍迹象也提早2.3年。 

Cullum博士指出,TBI激活神经细胞退行性变的过程,也有较早研究指出,TBI诱发了导致民众出现神经退行性疾病的危险因素,他们仍需进行更多的研究以探究TBI和MCI之间的关系。

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