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CLIN CANCER RES：KPC1泛素连接酶影响黑色素瘤NK-κB通路

2017-08-28 MedSci MedSci原创

黑色素瘤KPC1NF-κB
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NF-κB通路异常活动会诱导产生侵袭性更强的皮肤黑色素瘤亚型。研究黑色素瘤NF-κB通路的机制有助于选择针对该通路的靶向分子。KPC1，E3泛素连接酶，是NF-κB通路的调剂因素。CLIN CANCER RES近期发表了一篇文章，研究调节KPC1表达的机制以及其对黑色素瘤的临床影响。

NF-κB通路异常活动会诱导产生侵袭性更强的皮肤黑色素瘤亚型。研究黑色素瘤NF-κB通路的机制有助于选择针对该通路的靶向分子。KPC1，E3泛素连接酶，是NF-κB通路的调剂因素。CLIN CANCER RES近期发表了一篇文章，研究调节KPC1表达的机制以及其对黑色素瘤的临床影响。

作者通过分析黑色素瘤组织标本评估KPC1表达及遗传学调控的临床意义。并使用黑色素瘤细胞系研究KPC1和NK-κB之间的功能联系，KPC1遗传学调控，包括DNA甲基化和miRNA表达。研究结果表明，KPC1通过促进NK-κB1 p105 到p50 抑制黑色素瘤增殖。同时，与早期黑色素瘤相比，Ⅳ期黑色素瘤的KPC1表达显着下调。KPC1低表达与Ⅳ期黑色素瘤不良预后显着相关。此外，受DNA甲基化控制的高miR-155-5p表达，与KPC1下调显着相关。

文章最后认为，KPC1遗传调控与NF-κB通路活化，促进黑色素瘤进展相关。这些研究结果表明KPC1有作为潜在治疗靶点的可能。

原始出处：
Yuuki lida,Aaron Ciechanover,et al.Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.CLIN CANCER RES.August 2017 doi:10.1158/1078-0432.CCR-17-0146

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    2018-05-22 sunylz

    #色素#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1680436, encodeId=97581680436c7, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Tue May 22 14:24:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023411, encodeId=deed202341101, content=<a href='/topic/show?id=16639453872' target=_blank style='color:#2F92EE;'>#连接酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94538, encryptionId=16639453872, topicName=连接酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Sat Mar 17 21:24:00 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238579, encodeId=0e042385e9a7, content=好文.值得点赞.更值得收藏!慢慢领会学习的.给点个赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Wed Aug 30 08:18:45 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558831, encodeId=acf51558831a6, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Wed Aug 30 07:24:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564840, encodeId=57541564840d7, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Wed Aug 30 07:24:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238475, encodeId=049b2384e555, content=学习过了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Wed Aug 30 00:41:01 CST 2017, time=2017-08-30, status=1, ipAttribution=)]
    2018-03-17 lishiwen

    #连接酶#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1680436, encodeId=97581680436c7, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Tue May 22 14:24:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023411, encodeId=deed202341101, content=<a href='/topic/show?id=16639453872' target=_blank style='color:#2F92EE;'>#连接酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94538, encryptionId=16639453872, topicName=连接酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Sat Mar 17 21:24:00 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238579, encodeId=0e042385e9a7, content=好文.值得点赞.更值得收藏!慢慢领会学习的.给点个赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Wed Aug 30 08:18:45 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558831, encodeId=acf51558831a6, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Wed Aug 30 07:24:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564840, encodeId=57541564840d7, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Wed Aug 30 07:24:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238475, encodeId=049b2384e555, content=学习过了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Wed Aug 30 00:41:01 CST 2017, time=2017-08-30, status=1, ipAttribution=)]
    2017-08-30 lietome15

    好文.值得点赞.更值得收藏!慢慢领会学习的.给点个赞!

    0

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    2017-08-30 cqlidoudou

    #黑色素#

    0

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    2017-08-30 cqlidoudou

    #黑色素#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1680436, encodeId=97581680436c7, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Tue May 22 14:24:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023411, encodeId=deed202341101, content=<a href='/topic/show?id=16639453872' target=_blank style='color:#2F92EE;'>#连接酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94538, encryptionId=16639453872, topicName=连接酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Sat Mar 17 21:24:00 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238579, encodeId=0e042385e9a7, content=好文.值得点赞.更值得收藏!慢慢领会学习的.给点个赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Wed Aug 30 08:18:45 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558831, encodeId=acf51558831a6, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Wed Aug 30 07:24:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564840, encodeId=57541564840d7, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Wed Aug 30 07:24:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238475, encodeId=049b2384e555, content=学习过了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Wed Aug 30 00:41:01 CST 2017, time=2017-08-30, status=1, ipAttribution=)]
    2017-08-30 明天会更好！

    学习过了.谢谢分享!

    0

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