BMJ Open:中国中老年人心血管健康分数及动脉粥样硬化进展的改变

2015-09-18 MedSci MedSci原创

目的:美国心脏病协会(AHA)提出了四种心血管健康行为和3种健康因子的定义。基于这七个指标的心血管健康分数(CHS),评估了个人心血管健康状态的变化。这篇研究的主要目的是调查中老年人不同时间点CHS的改变是否与动脉粥样硬化的进展相关。实验设计:中国前瞻性队列研究方法:根据CHS的变化分为8组(≤-4, -3, -2, -1, 0, 1, 2 和 ≥3)。分析CHS的变化对臂踝脉搏波传导速度(baP

目的:美国心脏病协会(AHA)提出了四种心血管健康行为和3种健康因子的定义。基于这七个指标的心血管健康分数(CHS),评估了个人心血管健康状态的变化。这篇研究的主要目的是调查中老年人不同时间点CHS的改变是否与动脉粥样硬化的进展相关。

实验设计:国内前瞻性队列研究

方法:根据CHS的变化分为8组(≤-4, -3, -2, -1, 0, 1, 2 和 ≥3)。分析CHS的变化对臂踝脉搏波传导速度(baPWV)的变化影响,以及对动脉粥样硬化进展的影响。

受试者:共3951名受试者满足纳入标准(大于40岁,无卒中,短暂性脑缺血发作,心肌梗死病史),并且有完整的信息。

结果:随着CHS变化的增加,baPWV变化逐渐减少(分别为126.46±355.91, 78.4±343.81, 69.6±316.27, 49.59±287.57, 57.07±261.17, 40.45±264.27, 37.45±283.26 以及21.66±264.17 cm/s)。多变量线性回归分析表明这两个变量之间呈负相关,校正其他危险因素后,仍呈负相关。CHS每增加一分,baPWV下降15.22 cm/s。

结论:CHS变化与baPWV变化呈负相关,也证实了是中老年人动脉粥样硬化进展的的独立预测因子。

原文出处:

Gao J, Bao M, Liu Y,et al.Changes in cardiovascular health score and atherosclerosis progression in middle-aged and older persons in China: a cohort study. BMJ Open. 2015 Aug 26

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    2016-05-19 gaoxiaoe
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    2016-07-24 feather89
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