STM:吸烟者服用维生素增加患癌风险

2014-02-07 美文 参考消息网

据美联社1月29日报道,具有抗氧化功能的维生素被普遍认为可以产生抗癌作用。但针对吸烟者的研究却发现,大剂量服用维生素实际上可能会增加他们患上肿瘤的风险。一项新的研究现在或许能解释为何出现上述自相矛盾的情况。 瑞典科学家在实验中让一些患上早期肺癌的小鼠服用了抗氧化剂。他们观察到小鼠体内的肿瘤不断长大并具有很强的侵略性,以至于这些小鼠的死亡速度比未接受此种治疗的小鼠提高了一倍。 研究人员1月29日

据美联社1月29日报道,具有抗氧化功能的维生素被普遍认为可以产生抗癌作用。但针对吸烟者的研究却发现,大剂量服用维生素实际上可能会增加他们患上肿瘤的风险。一项新的研究现在或许能解释为何出现上述自相矛盾的情况。

瑞典科学家在实验中让一些患上早期肺癌的小鼠服用了抗氧化剂。他们观察到小鼠体内的肿瘤不断长大并具有很强的侵略性,以至于这些小鼠的死亡速度比未接受此种治疗的小鼠提高了一倍。

研究人员1月29日发布报告称,出现上述情况的原因是,额外摄入的维生素明显妨碍了小鼠体内一种主要抗癌机制的运转。

科学家们强调指出,他们基于针对小鼠的研究结果无法为公众提供一般性建议,但他们的发现为现有的谨慎使用抗氧化剂的做法提供了支持。

上述研究报告的作者之一、哥德堡大学教授马丁·贝尔戈说,“未经确诊的肺部肿瘤在很长一段时间内不会恶化”,但对于一些高危人群,如曾经的烟民而言,摄入额外的抗氧化剂“会加速肿瘤的生长”。

报道称,抗氧化剂是一些能够帮助细胞免受某种类型损伤的化合物。富含抗氧化剂的水果和蔬菜无疑是健康的。而以药物形式摄入过多的抗氧化剂从而给健康带来的影响则引发人们的质疑。针对人体的各项研究得出的结论各不相同,但并未证明维生素补充剂具有防癌作用。而一些研究则认为它们有可能对人体造成伤害。

20世纪90年代展开的一项研究发现,服用β-胡萝卜素会增加吸烟者患上肺癌的风险。不仅仅是吸烟者需要引起重视。2011年的一项研究指出,维生素E补充剂会增加男性患前列腺癌的风险。

美国国家癌症研究所表示,对于已经患上癌症的人而言,“在我们对抗氧化补充剂为癌症病人带来的效果有更多了解之前,癌症病人应谨慎服用这类药物”。

报道指出,但科学家们尚不能从生物学角度解释为何抗氧化剂或许会对人体产生伤害。《科学转化医学》杂志当日刊登的报告在这一方面迈出了第一步。

这项研究没有探讨抗氧化剂能否预防肿瘤的形成,而只是分析了癌症已经出现后所发生的情况。研究人员称,抗氧化剂阻止抑制肿瘤的基因p53获取抑制肿瘤的信号,从而让癌细胞得以从人体的防御系统中逃脱。

原始出处:

Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P, Bergo MO.Antioxidants accelerate lung cancer progression in mice.Sci Transl Med. 2014 Jan 29;6(221):221ra15. 【原文下载】

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1677898, encodeId=eb4016e789831, content=<a href='/topic/show?id=29a8168130f' target=_blank style='color:#2F92EE;'>#STM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16813, encryptionId=29a8168130f, topicName=STM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d76127619556, createdName=gdsun, createdTime=Mon Apr 14 17:20:00 CST 2014, time=2014-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061419, encodeId=2a9c2061419d7, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun Jul 27 08:20:00 CST 2014, time=2014-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413420, encodeId=a3461413420ac, content=<a href='/topic/show?id=3f225299942' target=_blank style='color:#2F92EE;'>#患癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52999, encryptionId=3f225299942, topicName=患癌风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b2c2959841, createdName=zzc2212, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601332, encodeId=bbdc1601332c4, content=<a href='/topic/show?id=5baa5299111' target=_blank style='color:#2F92EE;'>#患癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52991, encryptionId=5baa5299111, topicName=患癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=888f18872716, createdName=lq0307, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605081, encodeId=aa0e16050817e, content=<a href='/topic/show?id=5cba39435fd' target=_blank style='color:#2F92EE;'>#吸烟者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39435, encryptionId=5cba39435fd, topicName=吸烟者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8619318136, createdName=124984e7m89暂无昵称, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=)]
    2014-04-14 gdsun
  2. [GetPortalCommentsPageByObjectIdResponse(id=1677898, encodeId=eb4016e789831, content=<a href='/topic/show?id=29a8168130f' target=_blank style='color:#2F92EE;'>#STM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16813, encryptionId=29a8168130f, topicName=STM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d76127619556, createdName=gdsun, createdTime=Mon Apr 14 17:20:00 CST 2014, time=2014-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061419, encodeId=2a9c2061419d7, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun Jul 27 08:20:00 CST 2014, time=2014-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413420, encodeId=a3461413420ac, content=<a href='/topic/show?id=3f225299942' target=_blank style='color:#2F92EE;'>#患癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52999, encryptionId=3f225299942, topicName=患癌风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b2c2959841, createdName=zzc2212, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601332, encodeId=bbdc1601332c4, content=<a href='/topic/show?id=5baa5299111' target=_blank style='color:#2F92EE;'>#患癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52991, encryptionId=5baa5299111, topicName=患癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=888f18872716, createdName=lq0307, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605081, encodeId=aa0e16050817e, content=<a href='/topic/show?id=5cba39435fd' target=_blank style='color:#2F92EE;'>#吸烟者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39435, encryptionId=5cba39435fd, topicName=吸烟者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8619318136, createdName=124984e7m89暂无昵称, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=)]
    2014-07-27 sjq027
  3. [GetPortalCommentsPageByObjectIdResponse(id=1677898, encodeId=eb4016e789831, content=<a href='/topic/show?id=29a8168130f' target=_blank style='color:#2F92EE;'>#STM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16813, encryptionId=29a8168130f, topicName=STM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d76127619556, createdName=gdsun, createdTime=Mon Apr 14 17:20:00 CST 2014, time=2014-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061419, encodeId=2a9c2061419d7, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun Jul 27 08:20:00 CST 2014, time=2014-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413420, encodeId=a3461413420ac, content=<a href='/topic/show?id=3f225299942' target=_blank style='color:#2F92EE;'>#患癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52999, encryptionId=3f225299942, topicName=患癌风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b2c2959841, createdName=zzc2212, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601332, encodeId=bbdc1601332c4, content=<a href='/topic/show?id=5baa5299111' target=_blank style='color:#2F92EE;'>#患癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52991, encryptionId=5baa5299111, topicName=患癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=888f18872716, createdName=lq0307, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605081, encodeId=aa0e16050817e, content=<a href='/topic/show?id=5cba39435fd' target=_blank style='color:#2F92EE;'>#吸烟者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39435, encryptionId=5cba39435fd, topicName=吸烟者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8619318136, createdName=124984e7m89暂无昵称, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1677898, encodeId=eb4016e789831, content=<a href='/topic/show?id=29a8168130f' target=_blank style='color:#2F92EE;'>#STM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16813, encryptionId=29a8168130f, topicName=STM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d76127619556, createdName=gdsun, createdTime=Mon Apr 14 17:20:00 CST 2014, time=2014-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061419, encodeId=2a9c2061419d7, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun Jul 27 08:20:00 CST 2014, time=2014-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413420, encodeId=a3461413420ac, content=<a href='/topic/show?id=3f225299942' target=_blank style='color:#2F92EE;'>#患癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52999, encryptionId=3f225299942, topicName=患癌风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b2c2959841, createdName=zzc2212, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601332, encodeId=bbdc1601332c4, content=<a href='/topic/show?id=5baa5299111' target=_blank style='color:#2F92EE;'>#患癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52991, encryptionId=5baa5299111, topicName=患癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=888f18872716, createdName=lq0307, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605081, encodeId=aa0e16050817e, content=<a href='/topic/show?id=5cba39435fd' target=_blank style='color:#2F92EE;'>#吸烟者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39435, encryptionId=5cba39435fd, topicName=吸烟者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8619318136, createdName=124984e7m89暂无昵称, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=)]
    2014-02-09 lq0307
  5. [GetPortalCommentsPageByObjectIdResponse(id=1677898, encodeId=eb4016e789831, content=<a href='/topic/show?id=29a8168130f' target=_blank style='color:#2F92EE;'>#STM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16813, encryptionId=29a8168130f, topicName=STM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d76127619556, createdName=gdsun, createdTime=Mon Apr 14 17:20:00 CST 2014, time=2014-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061419, encodeId=2a9c2061419d7, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun Jul 27 08:20:00 CST 2014, time=2014-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413420, encodeId=a3461413420ac, content=<a href='/topic/show?id=3f225299942' target=_blank style='color:#2F92EE;'>#患癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52999, encryptionId=3f225299942, topicName=患癌风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b2c2959841, createdName=zzc2212, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601332, encodeId=bbdc1601332c4, content=<a href='/topic/show?id=5baa5299111' target=_blank style='color:#2F92EE;'>#患癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52991, encryptionId=5baa5299111, topicName=患癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=888f18872716, createdName=lq0307, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605081, encodeId=aa0e16050817e, content=<a href='/topic/show?id=5cba39435fd' target=_blank style='color:#2F92EE;'>#吸烟者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39435, encryptionId=5cba39435fd, topicName=吸烟者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8619318136, createdName=124984e7m89暂无昵称, createdTime=Sun Feb 09 02:20:00 CST 2014, time=2014-02-09, status=1, ipAttribution=)]

相关资讯

CEBP:吸烟增加鼻咽癌患者治疗失败的风险

中山大学附属肿瘤医院放疗科谢方云教授团队进行的一项研究,近日在美国癌症研究协会(American Association for Cancer Research, AACR)主办的《癌流行病学:生物标记与预防》(Cancer Epidemiol Biomarkers Prev. )杂志上发表,该研究证实曾经或正在吸烟的鼻咽癌患者治疗后疾病进展、复发、远处转移及死亡的风险明显

Arthritis Care Res :吸烟可延缓早期关节炎患者的影像学进展

为明确吸烟与早期关节炎病情的相关性,来自法国蒙彼利埃大学Lapeyronie医院的Veronique Vesperini博士等人进行了一项研究。该通过对早期关节炎患者的前瞻性队列研究评估正在吸烟(S)、有吸烟史(EX)以及无吸烟史(NS)对治疗反应及疾病影像学进展的影响,分析戒烟对关节炎预后的作用。研究结果发表于2013年12月的《关节炎治疗与研究》(Arthritis Care & Re

孕妇吸烟 胎儿系同性恋概率增加?

据外媒报道,荷兰神经学家日前发布一本新书探讨孕妇精神状态与未来幼儿成长的关系。他指出,妇女在怀孕期间压力的增加,可能增大幼儿成为同性恋的概率。该论断引发争议。 该新书表示,孕妇的生活状态将直接影响胎儿的荷尔蒙分泌以及大脑的形成,从而影响其性取向。其中一个章节专门讨论了同性恋的起源。 书中称,如果孕妇有吸烟、服食禁药的习惯,幼儿是同性恋的概率也将增加。 这本新书《我们是自己的大脑(We Are

吸烟危害超过想象

除了已知的肺癌风险外,吸烟还会导致糖尿病、肝癌、结肠癌、增龄性黄斑变性、勃起障碍……在吸烟被证明有害健康50周年之际,美国政府 17 日发布一份近千页的报告,大幅扩充与吸烟相关的疾病名单,并指出吸烟的危害超过人们此前的想象。 美国卫生与公众服务部、疾病控制和预防中心等机构当天在白宫举行仪式,纪念美国公共卫生局的第一份吸烟与健康报告发布 50 周年。在那份里程碑式的报告

吸烟与几乎所有器官疾病有关联

除了已知的肺癌风险外,吸烟还会导致糖尿病、肝癌、结肠癌、增龄性黄斑变性、勃起障碍……在吸烟被证明有害健康50周年之际,美国政府17日发布一份近千页的报告,大幅扩充与吸烟相关的疾病名单,并指出吸烟的危害超过人们此前的想象。 美国卫生与公众服务部、疾病控制和预防中心等机构当天在白宫举行仪式,纪念美国公共卫生局的第一份吸烟与健康报告发布50周年。在那份里程碑式的报告中,吸烟被明确认定会导致肺癌并增

卫计委:中国吸烟人数超过3亿 受二手烟危害人群达7.4亿

国家卫生和计划生育委员会宣传司副司长、新闻发言人姚宏文7日在国新办发布会上介绍,全国吸烟人数超过3亿,7.4亿非吸烟人群遭受二手烟危害。每年有100多万人死于吸烟相关疾病,约10万人死于二手烟暴露导致的相关疾病。自2006年《烟草控制框架公约》在中国生效以来,根据国务院履约工作部际协调领导小组的统一部署,各组成部门各司其职,多措并举,推动控烟工作取得了积极进展。姚宏文表示,中国是世界上最大的烟草生