JCEM:血清尿酸水平与非酒精性脂肪肝疾病的关系

2022-04-04 MedSci原创 MedSci原创

该研究支持非酒精性脂肪性肝病导致血清尿酸水平升高的因果关系,但该研究没有证实血清尿酸水平与非酒精性脂肪性肝病风险之间的因果关系。其潜在机制有待进一步研究。

观察性研究表明,非酒精性脂肪性肝病与血清尿酸密切相关。然而,由于它们之间存在负性因果关系,这些研究存在固有的偏倚风险。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,在这项研究中,研究人员采用孟德尔随机化(MR)研究来调查血清尿酸水平与非酒精性脂肪性肝病之间的因果关系。

研究人员对欧洲人群中血清尿酸(110347人)和非酒精性脂肪性肝病(1483例病例和17781例对照者)的全基因组关联研究(GWAS)的汇总数据进行了两例双向MR分析。首先,研究人员选择与血清尿酸相关的13个单核苷酸多态性(SNPs)作为工具,使用反方差加权(IVW)方法估计血清尿酸水平升高对非酒精性脂肪性肝病风险的因果效应。然后研究人员用3个SNPs作为非酒精性脂肪性肝病的遗传工具来进行MR评估。为了测试可靠性,研究人员还进行了进一步的灵敏度分析。

研究人员的MR分析显示非酒精性脂肪性肝病与血清尿酸水平相关(β=0.032,p=0.003)。使用其他MR方法和灵敏度分析也得到了类似的结果。血清尿酸水平升高的遗传易感性与非酒精性脂肪性肝病无关(IVW的MR,比值比(OR)=1.02,95%CI为0.90-1.15,p=0.775)。使用其他4种多效性稳健MR方法以及在敏感性分析中排除与潜在混杂因素相关的9个SNPs,也获得了类似的结果。

由此可见,该研究支持非酒精性脂肪性肝病导致血清尿酸水平升高的因果关系,但该研究没有证实血清尿酸水平与非酒精性脂肪性肝病风险之间的因果关系。其潜在机制有待进一步研究。

原始出处:

Shiwei Li,et al.Serum Uric Acid Levels and Non-alcoholic Fatty Liver Disease: A Two-sample Bidirectional Mendelian Randomization Study.JCEM.2022.https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac190/6562281

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    2022-10-14 smallant2015
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    2022-10-31 achengzhao
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