J Hypertens:血清尿酸对日本在职男性高血压发生的影响!

2018-05-13 xing.T MedSci原创

由此可见,血清尿酸水平与未来高血压发病率相关,在年轻男性、无糖尿病者和正常高密度脂蛋白胆固醇水平的日本男性在职人群中观察到了这种关联。

尿酸水平升高与心血管疾病风险增加有关,这可能与合并症混淆。近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员分析了血清尿酸对日本在职男性高血压风险的影响。

研究人员在2009年对2335名在职的年龄在18岁至64岁之间的无高血压的日本男性进行了评价。这些受试者从2009年到2015年共计被随访了6年。

随访期间,380名受试者发生高血压。根据血清尿酸四分位数5.1或更低、5.2-5.8、5.9-6.6和至少6.7mg/Ld的水平对发生高血压的比值比进行估计。最高血尿酸四分位数与最低尿酸四分位数相比,多变量调整后的高血压发生风险显著增高:最低四分位数的比值比为1(参考值),第二的四分位数为1.34(0.91-1.97),第三的四分位数为1.42(0.97-2.06),最高四分位数为1.65(1.14-2.40)。在分层分析中,血清尿酸水平与高血压发生之间的相关性在45岁以下和没有合并症(即糖尿病和低水平的高密度脂蛋白胆固醇)的患者中较为显著。

由此可见,血清尿酸水平与未来高血压发病率相关,在年轻男性、无糖尿病者和正常高密度脂蛋白胆固醇水平的日本男性在职人群中观察到了这种关联。

原始出处:

Kansui, Yasuo,et al. Impact of serum uric acid on incident hypertension in a worksite population of Japanese men.Journal of Hypertension. 2018. https://journals.lww.com/jhypertension/Abstract/publishahead/Impact_of_serum_uric_acid_on_incident_hypertension.97473.aspx

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    2018-06-19 feather89
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    2018-05-19 yfjms

    学习

    0

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    2018-05-15 惠映实验室

    学习了.谢谢分享.

    0

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    2018-05-15 yfjms

    学习

    0

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