EASD 2013:生育后代可降低女性1型糖尿病患者死亡率

2013-10-16 MedSci MedSci原创

第49届欧洲糖尿病研究协会(EASD2013)于9月23-27日在西班牙巴塞罗那召开。当地时间9月25日下午,在“1型糖尿病观察性研究(Type 1 diabetes observational studies)”壁报专场上,芬兰赫尔辛基大学Lena Sjǒberg博士及其同事共同完成的一项新研究表明,生育后代可以降低女性1型糖尿病患者的死亡率。既往研究证实,1型糖尿病患者的近期和远期并发症死亡率

第49届欧洲糖尿病研究协会(EASD2013)于9月23-27日在西班牙巴塞罗那召开。当地时间9月25日下午,在“1型糖尿病观察性研究(Type 1 diabetes observational studies)”壁报专场上,芬兰赫尔辛基大学Lena Sjǒberg博士及其同事共同完成的一项新研究表明,生育后代可以降低女性1型糖尿病患者的死亡率。

既往研究证实,1型糖尿病患者的近期和远期并发症死亡率增加。另外,其他研究也表明在普通人群中,有后代的男性和女性相比,没有后代的男性和女性与死亡率更高。比普通人群相比,儿童期发病的1型糖尿病男性和女性患者的后代相对较少。本研究比较儿童期发病的1型糖尿病患者与对照组普通人群,将重点探讨没有后代和已有后代的患者在死亡率上的差别。

结果表明,随访至2010年年底,共有1025名糖尿病患者和497名非糖尿病患者死亡。糖尿病患者的全因死亡率明显高于对照组:糖尿病组男性患者的全因死亡率是对照组男性的3倍,糖尿病组女性患者的全因死亡率是对照组女性的5倍。无论在糖尿病组还是对照组,男性的死亡率均高于比女性。但糖尿病组男性与女性的死亡率差异小于对照组,说明糖尿病缩小了性别之间的死亡差异。Sjǒberg博士解释说:“虽然糖尿病使女性死亡率增加,但并不意味着女性患者的全因死亡率也增加。”

研究发现,总体来说,生育后代越多,死亡率越低,但是这种趋势在女性中更明显。在试验组和对照组以及两性之间,有后代的人群全因死亡率减半。在女性糖尿病和非糖尿病人群中,生育降低了死亡率。而在男性中,这种差异并不明显。

研究者观点

Sjǒberg博士表示,已发现生育可以降低死亡率,这种作用在男性中甚微,但在女性中,在不考虑糖尿病病情的前提下,生孩子可以降低死亡率。性别之间存在差异的可能原因是女性1型糖尿病患者在怀孕期间能够更好地控制代谢状态,而且可持续到产后。

该研究也存在一定的局限性,身体状况极差的患者会选择不生育也可能是死亡率存在差异的原因之一。

原文出处:Mortality and having offspring in type 1 diabetes.

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    2014-03-12 okhuali
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    2013-10-18 qilu_qi

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