Neuropsychiatr Dis Treat:癫痫患者患抑郁障碍的患病率及相关危险因素

2015-11-20 徐媛 MedSci原创

本研究的目的是评估癫痫患者的抑郁病率和发病相关危险因素,尤其是潜在的致抑郁药物的使用。 研究人员纳入了289名来自克拉科夫大学附属医院门诊符合筛选标准的癫痫患者,符合标准的患者都通过BDI量表进行筛查,筛查过程中,BDI分值在大于12分的患者需要精神科医师进一步评估。 纳入患者的平均年龄为35.7岁,患有癫痫疾病的平均时间为14.7年,其中有63名(21.8%)患者为特发性全身性癫痫,局灶性癫

本研究的目的是评估癫痫患者的抑郁病率和发病相关危险因素,尤其是潜在的致抑郁药物的使用。

研究人员纳入了289名来自克拉科夫大学附属医院门诊符合筛选标准的癫痫患者,符合标准的患者都通过BDI量表进行筛查,筛查过程中,BDI分值在大于12分的患者需要精神科医师进一步评估。

纳入患者的平均年龄为35.7岁,患有癫痫疾病的平均时间为14.7年,其中有63名(21.8%)患者为特发性全身性癫痫,局灶性癫痫为189名(65.4%)和无分类癫痫37名(12.8%)。频繁癫痫发作(>1次/每月)有107名(37.0%)。有35名(12.1%)正在服用1种或以上潜在致抑郁药物(β-阻滞剂、雌激素和孕激素联合、皮质醇或氟桂嗪)。有115名(39.8%)患者BDI≥12分,精神科医师诊断后,有84名(29.1%)患者患有抑郁障碍。仅有20名(23.8%)患者进行了抗抑郁治疗。通过Logistic回归模型分析,与抑郁诊断相关的自变量包括频发癫痫(OR 2.43,95%CI 1.38-4.29,P=0.002)、潜在的导致抑郁药物(OR 3.33,95%CI 1.50-7.39,P=0.003)、年龄(OR 1.03,95%CI 1.01-1.05,P=0.005)和奥卡西平使用(OR 2.26,95%CI 1.04-4.9,P=0.038)。

在波兰,癫痫患者抑郁症的患病率达到29.1%。目前接受抗抑郁治疗的=不到四分之一。抑郁相关的独立变量包括年龄、癫痫发作频繁,奥卡西平使用或易患抑郁症的药物。

原始出处

Bosak M1, Turaj W1, Dudek D2, Siwek M2, Szczudlik A1.Depressogenic medications and other risk factors for depression among Polish patients with epilepsy.Neuropsychiatr Dis Treat. 2015 Sep 30;

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    2016-04-28 那夏花开

    早期干预

    0

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