Int.J.Epidemiol：服用维生素片无益
2012-01-01 MedSci MedSci原创
在Inernaltional Journal of Epidemiology发表的最新研究成果显示，服用维生素补充剂其实是有害的。英国《每日邮报》网站12月27日报道题：服用多种维生素片“对健康毫无影响”。 成百上千万英国人每天必服多种维生素片，希望借此防止体弱多病。然而根据一项大型研究的结果显示，尽管维生素补充剂要花掉人们成百上千万英镑，却对人们的健康毫无影响。 研究人员在6年多时间里跟踪调
在Inernaltional Journal of Epidemiology发表的最新研究成果显示，服用维生素补充剂其实是有害的。英国《每日邮报》网站12月27日报道题：服用多种维生素片“对健康毫无影响”。
成百上千万英国人每天必服多种维生素片，希望借此防止体弱多病。然而根据一项大型研究的结果显示，尽管维生素补充剂要花掉人们成百上千万英镑，却对人们的健康毫无影响。
研究人员在6年多时间里跟踪调查了超过8000人，发现服用补充剂的人患癌症和心脏病的几率与服用不合任何补充剂成分的对照剂的人一样。
在被问及对自身健康状况的感受时，两组人之间毫无差别。
专家称，这次对维生素片的最大规模调研表明，成百上千万消费者在补充剂上面浪费了钱财。
伦敦圣乔治医院的首席饮食学家凯瑟琳·柯林斯强调，许多服用者属于“提心吊胆的健康人”，也就是认定维生素片会确保他们不得大病的健康成年人。她说：“服用维生素片的都是提心吊胆的健康人，他们试图保护自己不得早老性痴呆、心脏病和中风。但他们是在浪费钱财。这项大型研究跟踪调查了很长时间，评估了从动作灵活性和血压到是否感到快乐或疼痛等方方面面。”
多种维生素片作为一种补充人体所需营养的快捷简便办法日益流行。但一系列调查研究表明，对有些人来说，维生素片可能有害无益。
去年发表的两项研究结果表明，维生素补充剂可能会提高患癌症的风险。一项研究发现，含维生素E、抗坏血酸、β-胡萝卜素、硒和锌的片剂使恶性黑色素瘤-最严重的皮肤癌——的患病风险提高了三倍。另一项研究发现，每天服用多种维生素片的女性患乳腺癌的可能性增加了20%。虽然维生素有害的证据还十分有限，但最新研究结果似乎证实，许多人至少是在不必要地服用补充剂。
以南锡大学的专家为首的一个法国研究小组跟踪调查了8112名志愿者，让他们在6年多时间里有的服用无效对照剂胶囊，有的服用含维生素C、维生素E、β-胡萝卜素、硒和锌的胶囊。
研究人员在实验开始和结束时分别评估了志愿者的健康状况，从身、心两方面衡量了他们的生活质量。
在分析两组各有多少人患上严重疾病时，研究人员发现差别极小。在服用补充剂的一组，30.5%的人遭遇过重大健康“事件”，比如癌症或心脏病。在服用无效对照剂的一组，这个比例为30.4%。
服用维生素的一组有120人患癌症，另一组有 139人。两组中患心脏病的人数分别是65人和57人。
在《国际流行病学期刊》（Inernaltional Journal of Epidemiology）刊登的研究报告中，研究人员指出：“服用补充剂可改善健康状况的看法在这项实验中未得到佐证。”（生物谷Bioon.com）
拓展阅读：
- JCEM：维生素D水平与II型糖尿病发展有关
- 心力衰竭病人恶化和低水平的维生素C和高水平hs-CRP相关
- AIM:服维生素或增加老年女性早逝风险
- JCO：适当补充维生素D降低患结直肠癌风险
- 维生素D与心血管健康？
- 25羟基维生素D3水平与狼疮活动负相关
Long-term antioxidant supplementation has no effect on health-related quality of life: The randomized, double-blind, placebo-controlled, primary prevention SU.VI.MAX trial
Serge Brianon, Stéphanie Boini, Sandrine Bertrais, Francis Guillemin Pilar Galan and Serge Hercberg
Background The effect of antioxidant vitamin and mineral supplementation on health is one of the most controversial issues in human nutrition. Our objective was to investigate the effect of nutritional doses of a combination of antioxidant vitamins and minerals on health-related quality of life (HRQoL) in a sample of healthy French adults. Methods SU.VI.MAX is a randomized, double-blind, placebo-controlled, primary prevention trial in which a total of 8112 participants received a single capsule daily containing either placebo or vitamin C 120 mg, vitamin E 30 mg, beta-carotene 6 mg, selenium 100 μg and zinc 20 mg. Participants completed HRQoL questionnaires (SF36 and GHQ12) at baseline and after a mean of 76.0 ± 4.2 months. Results Scores for physical dimensions tended to decrease over time, whereas those for mental dimensions tended to improve. No differences in changes over time were observed between the supplement and placebo groups. Participants who believed that they received placebo had lower HRQoL scores than did those who thought they had received supplements [SF36 Bodily pain (?3.3), General health (?2.2), Vitality (?1.6) dimensions and physical component summary score (?1.1) in men, and in SF36 Social functioning (?2.3), General health (?1.4) dimensions and physical component summary score (?0.7) in women]. Conclusions Long-term supplementation with antioxidant vitamins and minerals had no beneficial effect on HRQoL in this trial. This is contrary to conventional beliefs and claims that such an effect exists.
Taking multi-vitamin pills 'does nothing for our health'
By Daily Mail Reporter/27th December 2011
They are a daily essential for millions of Britons hoping to ward off ill-health.
But despite the millions of pounds spent on vitamin pills, they do nothing for our health, according to a major study.
Researchers spent more than six years following 8,000 people and found that those taking supplements were just as likely to have developed cancer or heart disease as those who took an identical-looking dummy pill.
And when they were questioned on how healthy they felt, there was hardly any difference between the two groups.
Experts said the study – one of the most extensive carried out into vitamin pills – suggested that millions of consumers may be wasting their money on supplements.
Many users fall into the category of the ‘worried well’ – healthy adults who believe the pills will insure them against deadly illnesses – according to Catherine Collins, chief dietician at St George’s Hospital in London.
She said: ‘It’s the worried well who are taking these pills to try and protect themselves against Alzheimer’s disease, heart attacks and strokes.
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