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Am J Kidney Dis：合并CKD-5D的房颤患者：口服抗凝药预防卒中效果如何？

2017-12-26 闫盈盈 环球医学

CKD-5D房颤口服抗凝药预防卒中效果
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2017年12月，发表在《Am J Kidney Dis》上的一项综述，对口服抗凝药用于合并5D期慢性肾病（CKD-5D）的房颤（AF）患者卒中预防的风险和获益的迫切性进行了阐述。

2017年12月，发表在《Am J Kidney Dis》上的一项综述，对口服抗凝药用于合并5D期慢性肾病（CKD-5D）的房颤（AF）患者卒中预防的风险和获益的迫切性进行了阐述。

与一般人群相比，CKD-5D患者的卒中风险高3倍多，并且85岁及以上的患者卒中发生率最高。AF是卒中的强烈危险因素。其最常见于心律失常人群并可影响＞7%的CKD-5D人群。在普通人群中，华法林的使用是公认的一项重要的非瓣膜性AF患者卒中预防的干预措施。然而，口服抗凝药用于CKD-5D和非瓣膜性AF患者的卒中预防在肾脏病领域内仍存争议。在这项全国肾脏基金会-肾脏病预后质量倡议（NKF-KDOQI）的争议报告中，研究人员讨论了现有的检测CKD-5D和AF患者使用华法林和相关卒中及出血风险的观察性研究。研究人员也讨论了CKD-5D和非瓣膜性AF患者中，非维生素K依赖口服抗凝药及其潜在用于卒中的预防。目前也迫切需要随机临床试验的数据来确定口服抗凝药用于合并CKD-5D的AF患者卒中预防的风险和获益。

原始出处：
Bansal VK, Herzog CA, Sarnak MJ,et al.Oral Anticoagulants to Prevent Stroke in Nonvalvular Atrial Fibrillation in Patients With CKD Stage 5D: An NKF-KDOQI Controversies Report.Am J Kidney Dis. 2017 Dec;70(6):859-868. doi: 10.1053/j.ajkd.2017.08.003. Epub 2017 Sep 21.

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    2018-05-18 cmj8wellington

    #Dis#

    0

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    2018-06-08 yaanren

    #CKD-5D#

    0

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    2017-12-28 hunizi005

    #口服抗凝药#

    0

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    2017-12-28 gwc389

    #kidney#

    0

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    2017-12-28 hittouch

    #房颤患者#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2012532, encodeId=83bc201253283, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri May 18 14:32:00 CST 2018, time=2018-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783253, encodeId=72811e83253e2, content=<a href='/topic/show?id=dc164e93b7' target=_blank style='color:#2F92EE;'>#CKD-5D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4793, encryptionId=dc164e93b7, topicName=CKD-5D)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Fri Jun 08 21:32:00 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1377395, encodeId=b43d13e73955a, content=<a href='/topic/show?id=3098382134a' target=_blank style='color:#2F92EE;'>#口服抗凝药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38213, encryptionId=3098382134a, topicName=口服抗凝药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49ef408, createdName=hunizi005, createdTime=Thu Dec 28 10:32:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603102, encodeId=9e86160310238, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Thu Dec 28 10:32:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614426, encodeId=2334161442675, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Thu Dec 28 10:32:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272764, encodeId=23062e2764ae, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Dec 26 21:46:54 CST 2017, time=2017-12-26, status=1, ipAttribution=)]
    2017-12-26 thlabcde

    好资料学习了!

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