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microRNA调节血管发育研究新进展

2010-12-30 MedSci原创 MedSci原创

microRNA血管
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近日，国际学术期刊Circulation Research在线发表了中科院上海生科院/ 上海交大医学院健康所核酸与分子医学研究组的最新研究进展：“Two Functional MicroRNA-126s Repress a Novel Target Gene P21-Activated Kinase1 to Regulate Vascular Integrity in Zebrafish”。 血

近日，国际学术期刊Circulation Research在线发表了中科院上海生科院/ 上海交大医学院健康所核酸与分子医学研究组的最新研究进展：“Two Functional MicroRNA-126s Repress a Novel Target Gene P21-Activated Kinase1 to Regulate Vascular Integrity in Zebrafish”。

血管发育是胚胎发育的重要过程，研究血管发育的分子机制有重要的生理和病理意义。microRNA-126是内皮细胞特异表达的微小RNA(miRNA)，参与调节血管生成和维持血管完整性，但其具体作用机制尚待进一步阐明。

健康科学研究所博士生邹俊和李文庆等在荆清研究员的指导下，并与研究所刘廷析研究员课题组合作，利用斑马鱼作为模式生物，发现在斑马鱼基因组内存在两个miR-126位点（miR-126a/b），可在体外和体内产生成熟有生物活性的miRNA。研究发现miR-126a/b参与调节胚胎血管完整性，且有协同效应。进一步研究表明，miR-126a/b通过调节内皮细胞中pak1的表达水平达到调节血管完整性目的。该研究拓宽了对内皮细胞 miRNA功能的认识，有助于阐明miRNA调节血管发育的作用机制和深入探索结构性血管疾病的发病机理。

该项研究工作得到了国家科技部、国家自然基金委、中国科学院的经费支持。

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    2011-08-17 jiafufeng@yaho

    #CRO#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1857273, encodeId=7773185e2734a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Wed Aug 17 02:55:00 CST 2011, time=2011-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084060, encodeId=828f208406098, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Jun 17 00:55:00 CST 2011, time=2011-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346963, encodeId=bde71346963ce, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sat Jan 01 07:55:00 CST 2011, time=2011-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435639, encodeId=c1351435639b8, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Jan 01 07:55:00 CST 2011, time=2011-01-01, status=1, ipAttribution=)]
    2011-06-17 xjy02

    #Micro#

    0

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    2011-01-01 neurowu

    #发育#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1857273, encodeId=7773185e2734a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Wed Aug 17 02:55:00 CST 2011, time=2011-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084060, encodeId=828f208406098, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Jun 17 00:55:00 CST 2011, time=2011-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346963, encodeId=bde71346963ce, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sat Jan 01 07:55:00 CST 2011, time=2011-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435639, encodeId=c1351435639b8, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Jan 01 07:55:00 CST 2011, time=2011-01-01, status=1, ipAttribution=)]
    2011-01-01 zhouqu_8

    #microRNA#

    0