JAHA:糖尿病对稳定胸痛患者评估的影响!

2017-10-31 xing.T MedSci原创

由此可见,稳定的胸痛患者无论有无糖尿病都有相似的临床表现和阻塞性CAD可能性;然而,医生认为糖尿病患者发生阻塞性CAD的可能性更高。需要进一步评估糖尿病对CAD评估的影响。

糖尿病对稳定的表现为冠状动脉疾病(CAD)症状的门诊患者临床表现和非侵入性检查(NIT)结果的影响还没有得到很好的描述。近日,心血管疾病领域权威杂志JAHA上针对这一问题发表了一篇研究文章。

该研究招募了10003名糖尿病患者,研究人员对其中8966人进行随机检测,并得到可解释的结果(1908名糖尿病患者,21%)。研究人员采用logistic回归评估症状和NIT结果的差异。

糖尿病患者和无糖尿病患者相比,其年龄(中位数为61岁和60岁)和性别(女性分别为54%和52%)相类似,但是糖尿病患者心血管合并症的负担更大,并无胸痛症状的几率类似(29% vs. 27%)。Diamond-Forrester/冠状动脉手术研究评分预测糖尿病患者与无糖尿病患者发生阻塞性冠心病的可能性相似(低1.8% vs. 2.7%,中间92.3% vs. 92.6%,高5.9% vs. 4.7%)。医生估计的糖尿病患者患阻塞性冠心病的可能性更高(从低到非常低:28.3% vs. 40.1%,中间63.9% vs. 55.9%,高到非常高7.8% vs. 4%)。糖尿病患者(与与无糖尿病患者相比)更可能出现阳性NIT结果(15% vs. 11%;调整后的比值比为1.23;P=0.01)。

由此可见,稳定的胸痛患者无论有无糖尿病都有相似的临床表现和阻塞性CAD可能性;然而,医生认为糖尿病患者发生阻塞性CAD的可能性更高。需要进一步评估糖尿病对CAD评估的影响。

原始出处:

Abhinav Sharma,et al. Impact of Diabetes Mellitus on the Evaluation of Stable Chest Pain Patients: Insights From the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) Trial.JAHA.2017. https://doi.org/10.1161/JAHA.117.007019

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=258432, encodeId=ee9d25843264, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Nov 03 20:25:12 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258103, encodeId=a021258103e4, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Nov 02 18:46:26 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267585, encodeId=c755126e58548, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Nov 02 10:29:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257569, encodeId=342225e569bc, content=很好的文章., beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/20/71f908320db34f36cac4a7c807970775.jpg, createdBy=c93a2154620, createdName=平静的光芒, createdTime=Tue Oct 31 19:36:29 CST 2017, time=2017-10-31, status=1, ipAttribution=)]
    2017-11-03 1e145228m78(暂无匿称)

    学习了谢谢作者分享!

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=258432, encodeId=ee9d25843264, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Nov 03 20:25:12 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258103, encodeId=a021258103e4, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Nov 02 18:46:26 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267585, encodeId=c755126e58548, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Nov 02 10:29:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257569, encodeId=342225e569bc, content=很好的文章., beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/20/71f908320db34f36cac4a7c807970775.jpg, createdBy=c93a2154620, createdName=平静的光芒, createdTime=Tue Oct 31 19:36:29 CST 2017, time=2017-10-31, status=1, ipAttribution=)]
    2017-11-02 1e145228m78(暂无匿称)

    学习了谢谢作者分享!

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=258432, encodeId=ee9d25843264, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Nov 03 20:25:12 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258103, encodeId=a021258103e4, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Nov 02 18:46:26 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267585, encodeId=c755126e58548, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Nov 02 10:29:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257569, encodeId=342225e569bc, content=很好的文章., beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/20/71f908320db34f36cac4a7c807970775.jpg, createdBy=c93a2154620, createdName=平静的光芒, createdTime=Tue Oct 31 19:36:29 CST 2017, time=2017-10-31, status=1, ipAttribution=)]
    2017-11-02 zhaohui6731
  4. [GetPortalCommentsPageByObjectIdResponse(id=258432, encodeId=ee9d25843264, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Nov 03 20:25:12 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258103, encodeId=a021258103e4, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Nov 02 18:46:26 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267585, encodeId=c755126e58548, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Nov 02 10:29:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257569, encodeId=342225e569bc, content=很好的文章., beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/20/71f908320db34f36cac4a7c807970775.jpg, createdBy=c93a2154620, createdName=平静的光芒, createdTime=Tue Oct 31 19:36:29 CST 2017, time=2017-10-31, status=1, ipAttribution=)]
    2017-10-31 平静的光芒

    很好的文章.

    0

相关资讯

Diabetes Care:研究确定糖尿病的“又”一大早期危险标志

近日,发表于《糖尿病护理》上的文章指出了动脉硬化和糖尿病发病率之间的关系。目前,2型糖尿病是影响着全球健康水平的关键因素,据研究,由于全球老龄化的影响,2型糖尿病的人数一直居高不下。而动脉硬化是冠心病,脑梗死和外周血管病的主要原因。那么动脉硬化与2型糖尿病又有什么关系呢?

Diabetes Care:糖尿病对心力衰竭患者长期生存结局的预后影响:Meta分析。

糖尿病对该患者群体死亡和住院风险的增加到底有多大贡献仍然是未知的。在此研究中,作者探讨了糖尿病对HF患者死亡率和住院时间长期风险的独立预后影响。

Diabetologia:在糖尿病小鼠模型中光感受器细胞产生炎症产物导致视网膜血管通透性增加

最近的研究表明,光感受器细胞产生的调节物或产物可导致糖尿病患者视网膜毛细血管损伤。近日,国际杂志 《Diabetologia》上在线发表一项关于在糖尿病小鼠模型中光感受器细胞产生炎症产物导致视网膜血管通透性增加的研究。本研究的目的是确定光感受器细胞是否释放提高糖尿病视网膜血管通透性的可溶性因子。

CLIN CANCER RES:糖尿病胰腺癌患者免疫缺陷特点

胰腺癌往往到疾病晚期才得以诊断,此时已没有有效的治疗手段。目前,免疫疗法为这一恶性肿瘤的治疗提供了新的希望。免疫治疗在许多类型的肿瘤患者中均有获益,但是胰腺癌患者并无获益。糖尿病和胰腺癌都是源于同一器官异常,糖尿病和胰腺癌有共同发生的倾向。CLIN CANCER RES近期发表了一篇文章,研究糖尿病对胰腺癌患者免疫治疗的影响。

Nat Chem Biol: 人造β细胞试验成功,一次注射可控制血糖长达五天!

治疗1型糖尿病和一些2型糖尿病患者长期需要痛苦和频繁的胰岛素注射或胰岛素输注的机械胰岛素泵。但北卡罗来纳大学和NC州立大学的研究人员现在已经开发出了一种更加耐心友好的选择:当葡萄糖水平上升时,人造细胞会自动将胰岛素释放到血液中。

Diabetes Care:警惕!这种糖尿病并发症无人幸免,一定要及早预防

近期,发表于《糖尿病护理》中的文章指出,大多数1型糖尿病患者有某种程度的肾病。