Audiol Neurootol:白藜芦醇能够促进听力在强烈噪音后的恢复

2018-02-25 AlexYang MedSci原创

去乙酰化SITR1是高度保守的烟酰胺腺嘌呤二核苷酸(NAD)依赖的蛋白去乙酰化酶,并且该物质对广泛的神经障碍都具有保护的作用。最近,有研究人员在C57BL/6小鼠中进行了长期的高剂量白藜芦醇食物喂养。研究人员发现,与那些标准喂养的小鼠相比,这些长期高剂量白藜芦醇喂养的小鼠展现出了增加的耳蜗SIRT1活性,并且还展现出了在强烈的噪音接触后,更好的听力恢复情况和听毛细胞更少的损失情况。更多的是,白藜芦

去乙酰化SITR1是高度保守的烟酰胺腺嘌呤二核苷酸(NAD)依赖的蛋白去乙酰化酶,并且该物质对广泛的神经障碍都具有保护的作用。

最近,有研究人员在C57BL/6小鼠中进行了长期的高剂量白藜芦醇食物喂养。研究人员发现,与那些标准喂养的小鼠相比,这些长期高剂量白藜芦醇喂养的小鼠展现出了增加的耳蜗SIRT1活性,并且还展现出了在强烈的噪音接触后,更好的听力恢复情况和听毛细胞更少的损失情况。更多的是,白藜芦醇可以缓解耳蜗SIRT1的减少和减少在噪音接触后耳蜗中的氧化胁迫。

最后,研究人员指出,他们的结果表明了白藜芦醇噪音诱导的听力损失方面,是一种潜在的可有希望的治疗药物。

原始出处:


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    2018-03-08 半夏微凉

    学习了谢谢分享

    0

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    2018-02-27 飛歌

    厉害了我的哥

    0

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    2018-02-27 明月清辉

    谢谢分享.学习了

    0

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    2018-02-27 龙胆草

    学习谢谢分享

    0

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    2018-02-27 ysjykql

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Acta Oncol:睾丸癌幸存者铂化疗前后听力损失研究

听力损失是睾丸癌幸存者(TCS)铂化合物化疗(CBCT)后长期的副作用结果,但是纵向数据仍旧缺乏。最近,有研究人员在他们的纵向研究中,在CBCT处理的TCS中评估了听力损失和年龄的影响。研究发现,年龄和铂剂量与在2-8kHz频率的听力阈值水平(HTL)的较大改变显著相关。对8kHz频率,每100mg累积铂剂量的增加均与3.6dB的退化相关((95% CI 1.8-5.3, p<0.001)。

Eur J Clin Nutr:红细胞叶酸、血清维生素B12和听力损失在2003-2002年国家健康和营养调查中的研究

关于食物频率调查问卷的研究表明了叶酸和维他命B12的摄入具有预防听力损失的作用。最近,有研究人员调查了是否红细胞叶酸和血清维他命B12水平与人类听力损失独立相关。研究包括了在2003-2004年美国国家健康和营养调查中的那些具有关于听力、叶酸和维生素B12水平数据的参与者。研究发现,参与者(n=1149)的平均年龄为20-69岁(均值为42),并且16.4%的参与者至少有一只耳朵具有听力损失。他们

Arch Dis Child:澳大利亚儿童听力损失代表性的流行病学研究

最近,有研究人员在澳大利亚年龄在11岁-12岁儿童的国家性研究中,调查了听力损失的流行和特征、人口统计学风险因素和自1990年来的增长趋势。研究包括了1485名儿童(49.8%为听力保留;49.7%为男孩),他们经历了气传导的听力测定。研究发现,对高弗莱彻指数,双边和单边听力损失不小于16dB HL的流行度分别为9.3%和13.3%。轻度听力损失(16-25dB HL)比中度或者更严重的(不小于2