Gastroenterology:首次结肠镜筛查结果可决定10年晚期肿瘤风险

2020-03-17 MedSci原创 MedSci原创

研究认为,基线结肠镜检查结果与10年晚期肿瘤风险显著相关,基线检查时只有1或2个小腺瘤的人群在10年内发生晚期肿瘤的风险较低

目前,结肠镜筛查人群的长期结果研究尚不充分,近日研究人员就基线筛查后10年,参与者的晚期肿瘤(定义为腺瘤≥10毫米、有绒毛组织学或高度异常增生的腺瘤或结直肠癌)风险进行了考察。

3121名无症状退伍军人参与研究,基线年龄50-75岁,从1994年到1997年在13个医疗中心接受了结肠镜检查,随访10年或参与者死亡,其中1915名参与者至少有1次结肠镜检查结果,研究的主要终点为晚期肿瘤的累积发生率。

在所有基线结肠镜筛查人群中,每146人中至少发现1例晚期肿瘤。基线CRC患者的晚期肿瘤的累积10年发生率最高 (43.7%),其次是基线晚期腺瘤(AA,21.9%)。基线检查中1-2个小腺瘤(<1cm,无绒毛组织学或高度异性增生)和无腺瘤人群的晚期肿瘤10年累积发病率分别为6.3%和4.1%。与无基线腺瘤的退伍军人相比,在基线时有1或2个小腺瘤患者的后续晚期肿瘤风险未见显著增加(优势比0.96)。

研究认为,基线结肠镜检查结果与10年晚期肿瘤风险显著相关,基线检查时只有1或2个小腺瘤的人群在10年内发生晚期肿瘤的风险较低。

原始出处:

David Lieberman et al. Baseline Colonoscopy Findings Associated With 10-Year Outcomes in a Screening Cohort Undergoing Colonoscopy Surveillance. Gastroenterology. March 2020.

 

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    2021-01-25 许安
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    2020-03-19 zhouqu_8
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