Br J Surg:降低心血管风险,可降低腹主动脉瘤死亡风险

2016-10-19 MedSci MedSci原创

接受腹主动脉瘤(AAA)修复术患者的围手术期死亡率低,但长期生存率仍然不佳。虽然诊断为腹主动脉瘤的患者有显著的心血管疾病负担和相关的风险因素,但心血管风险管理对患者的长期生存的贡献的认识是有限制的。心血管疾病的药物治疗方法被归类为抗血小板、他汀类或抗高血压药。12 485例患者有AAA诊断记录。从2000年到2012年,修改心血管风险的药物处方增加:他汀类药物从26•6%到76•7%,抗血小板药物

接受腹主动脉瘤(AAA)修复术患者的围手术期死亡率低,但长期生存率仍然不佳。虽然诊断为腹主动脉瘤的患者有显著的心血管疾病负担和相关的风险因素,但心血管风险管理对患者的长期生存的贡献的认识是有限制的。

心血管疾病的药物治疗方法被归类为抗血小板、他汀类或抗高血压药。

12 485例患者有AAA诊断记录。从2000年到2012年,修改心血管风险的药物处方增加:他汀类药物从26.6%到76.7%,抗血小板药物从56.5%到73.9%,抗高血压药物从75.3%到84.0%。

调整后的Kaplan Meier曲线表明。接受这些修改心血管风险的药物治疗的患者,与未接受治疗的患者相比,5年生存率更好:他汀类药物68.4 vs 42.2%,抗血小板药物63.6 vs 39.7%,降压药61.5 vs 39.1%。

适当的修改心血管风险的药物治疗能显著降低AAA患者的长期死亡率。在英国,高达30%的患者,目前还没有接受这些药物治疗。

原始出处:

Bahia SS1,2, Vidal-Diez A3,4, Seshasai SR4, Shpitser I5, Brownrigg JR3,4, Patterson BO3,4, Ray KK6, Holt PJ3,4, Thompson MM3,4, Karthikesalingam A3,4.Cardiovascular risk prevention and all-cause mortality in primary care patients with an abdominal aortic aneurysm.Br J Surg. 2016 Oct 5. doi: 10.1002/bjs.10269. [Epub ahead of print]

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