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Annal Oncol：CXCR4示胰腺癌远处转移

2012-03-03 MedSci MedSci原创

CXCR4胰腺癌转移
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　CXCR4与胰腺癌远处转移具有独立的强相关性，SMAD4阴性表达可能将被用于预测辅助化疗效果。该研究结果由法国学者2月29日在线发表于《肿瘤学年鉴》（Annals of Oncology）。 　　该研究共纳入了471例已接受手术切除治疗的胰腺癌患者，采用组织微阵列法评估了SMAD4、TGF-βⅡ型受体、CXCR4和LKB1的表达，并分析其与患者总生存状况的关联。 　　结果

　CXCR4与胰腺癌远处转移具有独立的强相关性，SMAD4阴性表达可能将被用于预测辅助化疗效果。该研究结果由法国学者2月29日在线发表于《肿瘤学年鉴》（Annals of Oncology）。

　　该研究共纳入了471例已接受手术切除治疗的胰腺癌患者，采用组织微阵列法评估了SMAD4、TGF-βⅡ型受体、CXCR4和LKB1的表达，并分析其与患者总生存状况的关联。

　　结果发现，CXCR4高表达是唯一与不良预后有独立相关性的生物标志物[危险比（HR）=1.74，P＜0.0001]，此外，它还与远处转移显著相关（HR=0.29，P＜0.0001）。在未接受辅助治疗的患者中，SMAD4阴性表达趋于与总生存率降低相关。再者，SMAD4阴性表达与复发类型无关，但对辅助化疗效果具有预测作用。

　　相关链接：Contribution of CXCR4 and SMAD4 in predicting disease progression pattern and benefit from adjuvant chemotherapy in resected pancreatic adenocarcinoma

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1864338, encodeId=7fc2186433828, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Thu Feb 14 14:45:00 CST 2013, time=2013-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412445, encodeId=f7cc1412445b3, content=<a href='/topic/show?id=c5d95546ff' target=_blank style='color:#2F92EE;'>#CXCR4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5546, encryptionId=c5d95546ff, topicName=CXCR4)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8c832868137, createdName=chenwq09, createdTime=Mon Mar 05 01:45:00 CST 2012, time=2012-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423485, encodeId=2f96142348555, content=<a href='/topic/show?id=badd9441868' target=_blank style='color:#2F92EE;'>#远处转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94418, encryptionId=badd9441868, topicName=远处转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c42b3793913, createdName=hanhaisha2009, createdTime=Mon Mar 05 01:45:00 CST 2012, time=2012-03-05, status=1, ipAttribution=)]
    2013-02-14 minlingfeng

    #Oncol#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1864338, encodeId=7fc2186433828, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Thu Feb 14 14:45:00 CST 2013, time=2013-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412445, encodeId=f7cc1412445b3, content=<a href='/topic/show?id=c5d95546ff' target=_blank style='color:#2F92EE;'>#CXCR4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5546, encryptionId=c5d95546ff, topicName=CXCR4)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8c832868137, createdName=chenwq09, createdTime=Mon Mar 05 01:45:00 CST 2012, time=2012-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423485, encodeId=2f96142348555, content=<a href='/topic/show?id=badd9441868' target=_blank style='color:#2F92EE;'>#远处转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94418, encryptionId=badd9441868, topicName=远处转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c42b3793913, createdName=hanhaisha2009, createdTime=Mon Mar 05 01:45:00 CST 2012, time=2012-03-05, status=1, ipAttribution=)]
    2012-03-05 chenwq09

    #CXCR4#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1864338, encodeId=7fc2186433828, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Thu Feb 14 14:45:00 CST 2013, time=2013-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412445, encodeId=f7cc1412445b3, content=<a href='/topic/show?id=c5d95546ff' target=_blank style='color:#2F92EE;'>#CXCR4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5546, encryptionId=c5d95546ff, topicName=CXCR4)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8c832868137, createdName=chenwq09, createdTime=Mon Mar 05 01:45:00 CST 2012, time=2012-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423485, encodeId=2f96142348555, content=<a href='/topic/show?id=badd9441868' target=_blank style='color:#2F92EE;'>#远处转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94418, encryptionId=badd9441868, topicName=远处转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c42b3793913, createdName=hanhaisha2009, createdTime=Mon Mar 05 01:45:00 CST 2012, time=2012-03-05, status=1, ipAttribution=)]
    2012-03-05 hanhaisha2009

    #远处转移#

    0