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基因变异导致中国人严重流感

2013-02-01 Tao Dong 《自然—通讯》

基因变异流感患者
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　　据《自然—通讯》文章报道，科学家在个别中国严重流感患者的细胞的细胞膜中发现了蛋白质 IFITM3 的基因变异。该基因变异可能和在中国地区和华人后代中严重传染的流感密切相关。 　　IFITM3 变异，SNP rs12252-C 等位基因，曾被证明会造成严重的病毒性疾病。这种基因变异很少出现在白种人身上，但频繁地出现在汉族人中。通过对2009 年流感期间中国地区入院患者的观察，陶冬和他的同事们报


　　据《自然—通讯》文章报道，科学家在个别中国严重流感患者的细胞的细胞膜中发现了蛋白质 IFITM3 的基因变异。该基因变异可能和在中国地区和华人后代中严重传染的流感密切相关。

　　IFITM3 变异，SNP rs12252-C 等位基因，曾被证明会造成严重的病毒性疾病。这种基因变异很少出现在白种人身上，但频繁地出现在汉族人中。通过对2009 年流感期间中国地区入院患者的观察，陶冬和他的同事们报告说，69% 被诊断患有严重流感的中国患者均携带 rs12252-C 基因，其特点是出现类似肺炎的症状，严重者甚至可以导致呼吸衰竭。相比之下，只有25% 的轻微患者携带这个基因，其症状包括发烧、头痛和嗜睡。这些结果表明 rs12252-C可能是感染严重流感的主要风险因素。研究人员指出，这种基因变异与流感的症状的严重程度有关，与传染容易程度无关。

　　针对确定IFITM3-sn12252 基因型分型能否在对中国和亚洲患者流感严重程度的早期预测中发挥作用，研究人员建议今后更大规模的研究。（来源：牛津大学 陶冬）

　　

Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals

Abstract
The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent.

    

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    2013-09-13 Jenifer

    Yes! Finally something about 34 menopause symptoms.

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=6145, encodeId=6bca614548, content=Yes! Finally something about 34 menopause symptoms., beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=Jenifer, createdTime=Fri Sep 13 17:53:00 CST 2013, time=2013-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=5494, encodeId=5ed15494a0, content=There's a seerct about your post. ICTYBTIHTKY, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=Resham, createdTime=Mon Mar 04 11:39:00 CST 2013, time=2013-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314122, encodeId=bd66131412264, content=<a href='/topic/show?id=b5e641e1279' target=_blank style='color:#2F92EE;'>#基因变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41712, encryptionId=b5e641e1279, topicName=基因变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512d422, createdName=canlab, createdTime=Sun Feb 03 04:31:00 CST 2013, time=2013-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342266, encodeId=7d15134226635, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sun Feb 03 04:31:00 CST 2013, time=2013-02-03, status=1, ipAttribution=)]
    2013-03-04 Resham

    There's a seerct about your post. ICTYBTIHTKY

    0

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    2013-02-03 canlab

    #基因变异#

    0

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    2013-02-03 12498dabm77暂无昵称

    #变异#

    0

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