Gastroenterology:炎症性肠病后息肉患者结肠癌风险评估

2018-12-11 zhangfan MedSci原创

研究认为,炎症性肠病后息肉患者其结直肠肿瘤风险与一般IBD患者相当,但结肠切除率增加

炎症性肠病(IBD)患者如发生炎症后息肉(PIPS),其结直肠肿瘤(CRN)风险可能增加。欧洲指南建议PIPS携带患者更频繁的接受结肠镜检查。近日研究人员就IBD-PIPs患者真实的CRN风险进行了考察。

1997-2017年间,IBD患者接受结肠镜检查,患者IBD至少病史8年,基线无进展期CRN(高级别不典型增生或直肠癌)或结肠切除术的病史。研究的主要终点为进展性CRN,次要终点包括CRN(包括低度异型增生)以及结肠切除术。

1582名患者参与研究,其中462人存在PIPs (29.2%)。PIPs与较重的炎症病情(OR=1.32)、较大的病变范围(OR=1.92)以及原发性硬化性胆管炎可能性降低(OR=0.38)相关。平均随访4.8年,有无PIPs与进展性CRN无关,不会独立增加患者CRN风险(HR=1.17),但PIPs组结肠切除率增加。

研究认为,炎症性肠病后息肉患者其结直肠肿瘤风险与一般IBD患者相当,但结肠切除率增加。

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    2019-10-12 sjq027
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    2019-07-08 许安
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    2018-12-23 183****7028

    学习

    0

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    2018-12-11 lietome15

    好文,值得点赞!认真学习,应用于实践!谢谢分享给广大同好!

    0

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