MCP：定量蛋白质组学评估黑色素瘤的药物反应与疗效

2014-07-03 佚名不详

近日，刊登在国际杂志Molecular and Cellular Proteomics上的一篇研究论文中，来自莫非特癌症研究中心的研究人员通过研究开发了一种新型方法，其可以帮助科学家们鉴别出耐药性黑色素瘤患者机体中潜在的治疗靶点；文章中研究者利用液相色谱多重反应监测质谱技术来监测患者血液或者组织中特殊的生物标志物分子来揭示是否癌症在患者机体存在，这些测定技术可以帮助研究者确定是否病人对疗法有反应。

近日，刊登在国际杂志Molecular and Cellular Proteomics上的一篇研究论文中，来自莫非特癌症研究中心的研究人员通过研究开发了一种新型方法，其可以帮助科学家们鉴别出耐药性黑色素瘤患者机体中潜在的治疗靶点；文章中研究者利用液相色谱多重反应监测质谱技术来监测患者血液或者组织中特殊的生物标志物分子来揭示是否癌症在患者机体存在，这些测定技术可以帮助研究者确定是否病人对疗法有反应。

此前研究中研究人员已经发现了促成黑色素瘤发展以及转移的关键分子，比如蛋白质BRAF以及MEK等，以这些分子为靶点的靶向性制剂在临床上表现出了很大潜力，而且经其治疗的患者机体的肿瘤生长也被明显抑制了。

研究者Keiran Smalley说道，肿瘤可以产生不同的耐药性机制以适应不同的靶向制剂，从而使得肿瘤细胞得以生存繁殖，而进行长期治疗的黑色素瘤病人也需要进行多种组合药物的治疗；在不同病人之间引发肿瘤耐药性的分子变化很大，鉴别出这些分子的改变目前来说非常耗时而且耗费资金。

这项研究中，研究者就利用这种新型技术-液相色谱多重反应监测质谱技术测定了和黑色素瘤发展以及耐药相关的80多种蛋白质，结果显示，以蛋白质MEK为靶点产生耐药的黑色素瘤细胞在一系列不同的细胞信号路径中发生了改变。这项研究对于开发新型治疗黑色素瘤的策略提供了一定的希望。

目前研究者希望加快速度鉴别出和黑色素瘤耐药性相关的蛋白质，而目前开发的新技术平台也将帮助研究者对一系列少量组织样本中的多种蛋白质同时进行检测，相信通过研究者不断的探索和研究未来将开发出新型治疗黑色素瘤的靶向疗法和策略。

原始出处

Rebecca VW1, Wood ER, Fedorenko IV, Paraiso KH, Haarberg HE, Chen Y, Xiang Y, Sarnaik A, Gibney GT, Sondak VK, Koomen JM, Smalley KS.Evaluating Melanoma Drug Response and Therapeutic Escape with Quantitative Proteomics.Mol Cell Proteomics. 2014 Apr 23

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2014-09-27 jjjiang0211

#蛋白质组#

29 0
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2014-10-08 lfcmxl

#药物反应#

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2015-01-15 sunylz

#色素#

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2015-04-07 柳叶一刀

#白质#

52 0
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2014-07-05 cmj8wellington

#蛋白质#

29 0
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2014-07-05 cqlidoudou

#黑色素#

24 0
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2014-07-05 cqlidoudou

#黑色素#

15 0

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MCP：定量蛋白质组学评估黑色素瘤的药物反应与疗效

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