房颤消融停用抗凝药导致大脑损伤发生率翻倍

2017-06-22 许菁 中国循环杂志

澳大利亚Elisabethinen医院学者在欧洲心律协会2017年会上发布的一项前瞻性研究数据表明,房颤消融前停用抗凝药有可能会导致无症状大脑损伤发生率翻倍,因此研究者建议房颤消融无需停用抗凝药。

澳大利亚Elisabethinen医院学者在欧洲心律协会2017年会上发布的一项前瞻性研究数据表明,房颤消融前停用抗凝药有可能会导致无症状大脑损伤发生率翻倍,因此研究者建议房颤消融无需停用抗凝药。

本研究中,与消融期间坚持抗凝治疗者相比,停用抗凝的患者术后无症状脑损伤发生率增加近一倍(17.3% vs 9.6%)。

而且房颤消融患者不停用抗凝药物也不会导致出血风险的增加。

进一步分析发现,新发无症状脑损伤的预测因素包括左心房内径较大、卒中风险评分较高及消融手术期间活化凝血时间更低。

研究续入选410例既往接受口服抗凝药治疗的房颤消融患者,于术前、后采用核磁共振成像评估脑损伤。


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