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Science: 动脉粥样硬化会引起慢性炎症反应

2015-07-21 佚名 生物谷

动脉粥样硬化　慢性炎症
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近日，来自伦敦Francis Crick研究所的研究人员发现了一种网状结构,并将其称为为中性粒细胞细胞外陷阱 (NETs)。这种结构在患有动脉粥样硬化的小鼠体内，可以促进炎症反应。NETs是如何形成的及其在慢性炎症中的作用等相关研究结果，发表在最近一期Science杂志上。 众所周知，动脉粥样硬化是脂肪或其他物质，在动脉血管管壁黏附及 堆积所形成的。它的存在对健康有害，因为会引起心脏病或中风

近日，来自伦敦Francis Crick研究所的研究人员发现了一种网状结构,并将其称为为中性粒细胞细胞外陷阱 (NETs)。这种结构在患有动脉粥样硬化的小鼠体内，可以促进炎症反应。NETs是如何形成的及其在慢性炎症中的作用等相关研究结果，发表在最近一期Science杂志上。

众所周知，动脉粥样硬化是脂肪或其他物质，在动脉血管管壁黏附及 堆积所形成的。它的存在对健康有害，因为会引起心脏病或中风。在此项研究中，研究人员利用小鼠动脉粥样硬化模型发现，动脉粥样硬化还会引起慢性炎症，这是由免疫反应引起的，包括中性粒细胞及巨噬细胞。

中性粒细胞在非特异性免疫系统中起到了十分重要的作用，它们可以抵御微生物的入侵。在中性粒细胞与微生物持续战斗一段时间后，机体会发出增援信号，以组蛋白，DNA及髓过氧化物酶等形式，支援中性粒细胞弹性蛋白酶，这些物质一起形成了中性粒细胞细胞外陷阱 (NETs)。研究人员发现，在动脉粥样硬化的小鼠模型中，胆固醇结晶可以引发中性粒细胞形成NETs。NETs接着会激活巨噬细胞，分泌出细胞因子，白介素-1β (IL-1β)， 从而激活了辅助性T细胞17 (TH17)，扩大了免疫细胞在粥样硬化灶的聚集，最后引起慢性炎症反应。

在今后的研究中，研究人员们将进一步研究NETs形成的详细机制，及其形成是否可以避免。由于此项研究均在小鼠动脉粥样硬化模型中完成，研究人员下一步将开展研究，在人类患者，是否也有NETs的形成及其是否也有相同的功能。


原始出处：

Annika Warnatsch, Marianna Ioannou, Qian Wang, Venizelos Papayannopoulos*.Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis.Science.July 17, 2015.DOI: 10.1126/science.aaa8064

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    2015-10-24 huangshifeng

    #粥样硬化#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1944386, encodeId=b283194438610, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Sat Oct 24 09:19:00 CST 2015, time=2015-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35056, encodeId=2fdb35056a8, content=对目前研究提供了极大帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 22:56:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33578, encodeId=463e335e847, content=相辅相成，同意楼上说法！, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e7a60478, createdName=cqj4023773, createdTime=Mon Jul 27 19:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33458, encodeId=d7283345829, content=相辅相成，导演兼演员, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed101627734, createdName=Messichen1992, createdTime=Sat Jul 25 09:53:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1320814, encodeId=dafa13208143d, content=<a href='/topic/show?id=43de6e0076f' target=_blank style='color:#2F92EE;'>#炎症反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67007, encryptionId=43de6e0076f, topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Thu Jul 23 00:19:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375072, encodeId=b24d13e50721f, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Thu Jul 23 00:19:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33220, encodeId=beaa33220c4, content=相互促进, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c09d1605573, createdName=aa6081, createdTime=Tue Jul 21 13:06:00 CST 2015, time=2015-07-21, status=1, ipAttribution=)]
    2015-08-06 hlycom3356

    对目前研究提供了极大帮助

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1944386, encodeId=b283194438610, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Sat Oct 24 09:19:00 CST 2015, time=2015-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35056, encodeId=2fdb35056a8, content=对目前研究提供了极大帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 22:56:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33578, encodeId=463e335e847, content=相辅相成，同意楼上说法！, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e7a60478, createdName=cqj4023773, createdTime=Mon Jul 27 19:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33458, encodeId=d7283345829, content=相辅相成，导演兼演员, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed101627734, createdName=Messichen1992, createdTime=Sat Jul 25 09:53:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1320814, encodeId=dafa13208143d, content=<a href='/topic/show?id=43de6e0076f' target=_blank style='color:#2F92EE;'>#炎症反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67007, encryptionId=43de6e0076f, topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Thu Jul 23 00:19:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375072, encodeId=b24d13e50721f, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Thu Jul 23 00:19:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33220, encodeId=beaa33220c4, content=相互促进, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c09d1605573, createdName=aa6081, createdTime=Tue Jul 21 13:06:00 CST 2015, time=2015-07-21, status=1, ipAttribution=)]
    2015-07-27 cqj4023773

    相辅相成，同意楼上说法！

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1944386, encodeId=b283194438610, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Sat Oct 24 09:19:00 CST 2015, time=2015-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35056, encodeId=2fdb35056a8, content=对目前研究提供了极大帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 22:56:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33578, encodeId=463e335e847, content=相辅相成，同意楼上说法！, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e7a60478, createdName=cqj4023773, createdTime=Mon Jul 27 19:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33458, encodeId=d7283345829, content=相辅相成，导演兼演员, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed101627734, createdName=Messichen1992, createdTime=Sat Jul 25 09:53:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1320814, encodeId=dafa13208143d, content=<a href='/topic/show?id=43de6e0076f' target=_blank style='color:#2F92EE;'>#炎症反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67007, encryptionId=43de6e0076f, topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Thu Jul 23 00:19:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375072, encodeId=b24d13e50721f, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Thu Jul 23 00:19:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33220, encodeId=beaa33220c4, content=相互促进, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c09d1605573, createdName=aa6081, createdTime=Tue Jul 21 13:06:00 CST 2015, time=2015-07-21, status=1, ipAttribution=)]
    2015-07-25 Messichen1992

    相辅相成，导演兼演员

    0

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    2015-07-23 lsj628

    #炎症反应#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1944386, encodeId=b283194438610, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Sat Oct 24 09:19:00 CST 2015, time=2015-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35056, encodeId=2fdb35056a8, content=对目前研究提供了极大帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 22:56:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33578, encodeId=463e335e847, content=相辅相成，同意楼上说法！, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e7a60478, createdName=cqj4023773, createdTime=Mon Jul 27 19:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33458, encodeId=d7283345829, content=相辅相成，导演兼演员, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed101627734, createdName=Messichen1992, createdTime=Sat Jul 25 09:53:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1320814, encodeId=dafa13208143d, content=<a href='/topic/show?id=43de6e0076f' target=_blank style='color:#2F92EE;'>#炎症反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67007, encryptionId=43de6e0076f, topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Thu Jul 23 00:19:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375072, encodeId=b24d13e50721f, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Thu Jul 23 00:19:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33220, encodeId=beaa33220c4, content=相互促进, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c09d1605573, createdName=aa6081, createdTime=Tue Jul 21 13:06:00 CST 2015, time=2015-07-21, status=1, ipAttribution=)]
    2015-07-23 jichang

    #SCIE#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1944386, encodeId=b283194438610, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Sat Oct 24 09:19:00 CST 2015, time=2015-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35056, encodeId=2fdb35056a8, content=对目前研究提供了极大帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 22:56:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33578, encodeId=463e335e847, content=相辅相成，同意楼上说法！, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e7a60478, createdName=cqj4023773, createdTime=Mon Jul 27 19:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33458, encodeId=d7283345829, content=相辅相成，导演兼演员, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed101627734, createdName=Messichen1992, createdTime=Sat Jul 25 09:53:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1320814, encodeId=dafa13208143d, content=<a href='/topic/show?id=43de6e0076f' target=_blank style='color:#2F92EE;'>#炎症反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67007, encryptionId=43de6e0076f, topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Thu Jul 23 00:19:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375072, encodeId=b24d13e50721f, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Thu Jul 23 00:19:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33220, encodeId=beaa33220c4, content=相互促进, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c09d1605573, createdName=aa6081, createdTime=Tue Jul 21 13:06:00 CST 2015, time=2015-07-21, status=1, ipAttribution=)]
    2015-07-21 aa6081

    相互促进

    0