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中法国际乳腺癌学术论坛：张频教授：晚期乳腺癌内分泌联合治疗的优选

2018-04-26 肿瘤资讯编辑部 肿瘤资讯

中法国际乳腺癌学术论坛晚期内分泌联合治疗
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山城四月，春意盎然，第八届中法国际乳腺癌高级学术论坛于2018年4月19-21日在重庆成功召开。本次大会的主题为“乳腺癌精准治疗”，国内众多顶级乳腺癌专家共聚一堂，传递与分享乳腺癌精准治疗的前沿信息。有幸邀请到中国医学科学院肿瘤医院内科张频教授谈谈晚期乳腺癌内分泌联合靶向治疗的选择。

山城四月，春意盎然，第八届中法国际乳腺癌高级学术论坛于2018年4月19-21日在重庆成功召开。本次大会的主题为“乳腺癌精准治疗”，国内众多顶级乳腺癌专家共聚一堂，传递与分享乳腺癌精准治疗的前沿信息。有幸邀请到中国医学科学院肿瘤医院内科张频教授谈谈晚期乳腺癌内分泌联合靶向治疗的选择。

张频主任,中国医学科学院肿瘤医院内科 主任医师 博士研究生导师.北京乳腺病防治学会内科专业委员会 副主任委员.中国老年学会乳腺癌分委会 副主任委员.北京医学会乳腺疾病分会 副主任委员.中国医师协会乳腺疾病培训专家委员会 常委.中国女医师协会临床肿瘤学专家委员会 常委.中国研究型医院学会乳腺专业委员会 常委.中国抗癌协会乳腺癌专业委员会 委员.中国抗癌协会肿瘤临床化疗专业委员会 委员.北京医师协会乳腺疾病专家委员会 委员

肿瘤资讯：作为最有效的晚期内分泌治疗单药，氟维司群已被列入国家医保目录，可否请您谈一下氟维司群在您所在地区的医保和临床使用情况。

张频教授：氟维司群于去年9月在北京被纳入医保范围，对于晚期激素受体阳性的乳腺癌患者是个巨大的好消息。虽然氟维司群在一线和二线内分泌治疗中取得了非常好的疗效，但在我国由于价格的原因以及医保报销的问题，临床应用受到一定的限制。去年正式被纳入北京医保后，我们发现有更多的患者愿意接受治疗，同时医生也更多的根据临床研究的证据推荐氟维司群作为一线和二线用药。

肿瘤资讯：晚期乳腺癌进入内分泌+的时代，几乎所有的靶向药物都会联合氟维司群，您如何从作用机理解读内分泌治疗联合靶向治疗的优势。

张频教授：近些年靶向治疗在激素受体阳性乳腺癌中的研究是非常多，其中最受关注的是CDK4/6抑制剂。既往研究显示氟维司群是内分泌单药疗效最好的药物，但CDK4/6抑制剂作为内分泌治疗的增强剂，在二线治疗中可以克服内分泌治疗耐药，为内分泌治疗进展患者提供一种新选择。如果在一线治疗时能联合CDK4/6抑制剂，将会为患者带来更长的无进展生存期和临床获益。虽然目前CDK4/6抑制剂在国内还未批准上市，但关于该药物的临床研究正在一些大型医院进行，患者有机会进入临床试验来优先接受治疗。

在一线和二线治疗中，CDK4/6抑制剂联合芳香化酶抑制剂或氟维司群都能有明显的PFS获益。因此，各大指南也推荐联合治疗作为一线或二线标准治疗方案。在既往临床研究中，一线治疗多选择CDK4/6抑制剂联合芳香化酶抑制剂，而二线治疗是常规联合氟维司群。随着氟维司群纳入医保，更多患者会在一线治疗时开始使用。相信在今后的临床实践中，氟维司群在内分泌一线和二线治疗中会发挥着更为重要作用。一旦CDK4/6抑制剂在国内获批，会有更多患者受益于联合治疗。

肿瘤资讯：您觉得内分泌联合靶向治疗的适用人群有哪些？

张频教授：靶向药物价格昂贵，即使将来在国内获批也不是所有患者都有经济条件使用，也不会立刻纳入医保。同时，在临床试验的亚组分析中，可以发现并不是所有患者都能从CDK4/6抑制剂中获益，对于疾病进展缓慢，非内脏转移及单纯骨转移患者，一线治疗选择内分泌单药也会有长的PFS获益。

因此，对于晚期乳腺癌患者的一线内分泌治疗方案，需要根据患者的具体情况决定选择单药还是联合靶向药物。对于无病生存期较长、单纯骨转移以及非内脏转移患者来说，单药内分泌治疗特别是氟维司群是足够的。而对于肿瘤负荷相对较大以及合并内脏转移患者，如果暂时不需要接受化疗，可以选择内分泌药物加上CDK4/6抑制剂联合治疗，能获得同样的疗效。因此对于这种类型的患者，内分泌联合靶向治疗不仅能带来生存获益，也能减轻化疗毒副反应，使病人获得更好的生活质量和更长的疾病控制。

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    2018-10-23 zhzhxiang

    #中法国际#

    0

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    2018-05-22 gwc392

    #分泌#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1797052, encodeId=52ec1e97052e1, content=<a href='/topic/show?id=55b2223227e' target=_blank style='color:#2F92EE;'>#中法国际#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22322, encryptionId=55b2223227e, topicName=中法国际)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Tue Oct 23 06:43:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682428, encodeId=374b16824283a, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Tue May 22 11:43:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310507, encodeId=92bf31050e7b, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Apr 30 00:02:50 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310246, encodeId=9fb7310246a9, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sun Apr 29 02:00:09 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310245, encodeId=b6d43102450f, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sun Apr 29 02:00:03 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313700, encodeId=11e81313e001e, content=<a href='/topic/show?id=d4cc80e128f' target=_blank style='color:#2F92EE;'>#联合治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80712, encryptionId=d4cc80e128f, topicName=联合治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=263b421, createdName=zhaozuguo, createdTime=Fri Apr 27 23:43:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399894, encodeId=33c9139989472, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, createdName=neurowu, createdTime=Fri Apr 27 23:43:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309598, encodeId=d77f309598d7, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Fri Apr 27 00:05:18 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-04-30 jihuaijun1112

    学习学习学习

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1797052, encodeId=52ec1e97052e1, content=<a href='/topic/show?id=55b2223227e' target=_blank style='color:#2F92EE;'>#中法国际#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22322, encryptionId=55b2223227e, topicName=中法国际)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Tue Oct 23 06:43:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682428, encodeId=374b16824283a, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Tue May 22 11:43:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310507, encodeId=92bf31050e7b, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Apr 30 00:02:50 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310246, encodeId=9fb7310246a9, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sun Apr 29 02:00:09 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310245, encodeId=b6d43102450f, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sun Apr 29 02:00:03 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313700, encodeId=11e81313e001e, content=<a href='/topic/show?id=d4cc80e128f' target=_blank style='color:#2F92EE;'>#联合治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80712, encryptionId=d4cc80e128f, topicName=联合治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=263b421, createdName=zhaozuguo, createdTime=Fri Apr 27 23:43:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399894, encodeId=33c9139989472, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, createdName=neurowu, createdTime=Fri Apr 27 23:43:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309598, encodeId=d77f309598d7, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Fri Apr 27 00:05:18 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-04-29 jihuaijun1112

    学习学习学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1797052, encodeId=52ec1e97052e1, content=<a href='/topic/show?id=55b2223227e' target=_blank style='color:#2F92EE;'>#中法国际#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22322, encryptionId=55b2223227e, topicName=中法国际)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Tue Oct 23 06:43:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682428, encodeId=374b16824283a, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Tue May 22 11:43:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310507, encodeId=92bf31050e7b, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Apr 30 00:02:50 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310246, encodeId=9fb7310246a9, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sun Apr 29 02:00:09 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310245, encodeId=b6d43102450f, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sun Apr 29 02:00:03 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313700, encodeId=11e81313e001e, content=<a href='/topic/show?id=d4cc80e128f' target=_blank style='color:#2F92EE;'>#联合治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80712, encryptionId=d4cc80e128f, topicName=联合治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=263b421, createdName=zhaozuguo, createdTime=Fri Apr 27 23:43:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399894, encodeId=33c9139989472, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, createdName=neurowu, createdTime=Fri Apr 27 23:43:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309598, encodeId=d77f309598d7, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Fri Apr 27 00:05:18 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-04-29 jihuaijun1112

    学习学习学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1797052, encodeId=52ec1e97052e1, content=<a href='/topic/show?id=55b2223227e' target=_blank style='color:#2F92EE;'>#中法国际#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22322, encryptionId=55b2223227e, topicName=中法国际)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Tue Oct 23 06:43:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682428, encodeId=374b16824283a, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Tue May 22 11:43:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310507, encodeId=92bf31050e7b, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Apr 30 00:02:50 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310246, encodeId=9fb7310246a9, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sun Apr 29 02:00:09 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310245, encodeId=b6d43102450f, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sun Apr 29 02:00:03 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313700, encodeId=11e81313e001e, content=<a href='/topic/show?id=d4cc80e128f' target=_blank style='color:#2F92EE;'>#联合治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80712, encryptionId=d4cc80e128f, topicName=联合治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=263b421, createdName=zhaozuguo, createdTime=Fri Apr 27 23:43:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399894, encodeId=33c9139989472, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, createdName=neurowu, createdTime=Fri Apr 27 23:43:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309598, encodeId=d77f309598d7, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Fri Apr 27 00:05:18 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-04-27 zhaozuguo

    #联合治疗#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1797052, encodeId=52ec1e97052e1, content=<a href='/topic/show?id=55b2223227e' target=_blank style='color:#2F92EE;'>#中法国际#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22322, encryptionId=55b2223227e, topicName=中法国际)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Tue Oct 23 06:43:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682428, encodeId=374b16824283a, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Tue May 22 11:43:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310507, encodeId=92bf31050e7b, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Apr 30 00:02:50 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310246, encodeId=9fb7310246a9, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sun Apr 29 02:00:09 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310245, encodeId=b6d43102450f, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sun Apr 29 02:00:03 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313700, encodeId=11e81313e001e, content=<a href='/topic/show?id=d4cc80e128f' target=_blank style='color:#2F92EE;'>#联合治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80712, encryptionId=d4cc80e128f, topicName=联合治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=263b421, createdName=zhaozuguo, createdTime=Fri Apr 27 23:43:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399894, encodeId=33c9139989472, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, createdName=neurowu, createdTime=Fri Apr 27 23:43:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309598, encodeId=d77f309598d7, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Fri Apr 27 00:05:18 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-04-27 neurowu

    #法国#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1797052, encodeId=52ec1e97052e1, content=<a href='/topic/show?id=55b2223227e' target=_blank style='color:#2F92EE;'>#中法国际#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22322, encryptionId=55b2223227e, topicName=中法国际)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Tue Oct 23 06:43:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682428, encodeId=374b16824283a, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Tue May 22 11:43:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310507, encodeId=92bf31050e7b, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Apr 30 00:02:50 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310246, encodeId=9fb7310246a9, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sun Apr 29 02:00:09 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310245, encodeId=b6d43102450f, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sun Apr 29 02:00:03 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313700, encodeId=11e81313e001e, content=<a href='/topic/show?id=d4cc80e128f' target=_blank style='color:#2F92EE;'>#联合治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80712, encryptionId=d4cc80e128f, topicName=联合治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=263b421, createdName=zhaozuguo, createdTime=Fri Apr 27 23:43:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399894, encodeId=33c9139989472, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, createdName=neurowu, createdTime=Fri Apr 27 23:43:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309598, encodeId=d77f309598d7, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Fri Apr 27 00:05:18 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-04-27 jihuaijun1112

    学习学习学习

    0