J Dent:益生菌或可用于牙周疾病的预防和治疗

2016-03-13 MedSci MedSci原创

J Dent:益生菌或可用于牙周疾病的预防和治疗据发表于Journal of dentistry的一项新的荟萃分析发现,益生菌疗法可用于牙周疾病的治疗,但是对于龋齿,则需进一步的研究以确定其疗效和安全性。益生菌或有助于龋齿、牙龈炎或牙周炎的预防或治疗。本次系统性回顾和荟萃分析旨在评估益生菌用于管理龋齿和牙周疾病的效果。研究人员检索了Medl ine、Embase和Central数据库,共纳入了50

据发表于Journal of dentistry的一项新的荟萃分析发现,益生菌疗法可用于牙周疾病的治疗,但是对于龋齿,则需进一步的研究以确定其疗效和安全性。

益生菌或有助于龋齿、牙龈炎或牙周炎的预防或治疗。本次系统性回顾和荟萃分析旨在评估益生菌用于管理龋齿和牙周疾病的效果。

研究人员检索了Medl ine、Embase和Central数据库,共纳入了50项研究(3247名参与者)符合条件的研究。包括对比了益生菌与安慰剂在变形链球菌(SM)、乳酸杆菌(LB)、牙周致病菌的数量,牙龈炎,口腔卫生,患龋率/龋经历的增加或牙周炎的随机对照试验。随后进行了荟萃分析和试验序列分析。

这些研究主要在儿童中进行,研究所用的益生菌为乳酸杆菌,双歧杆菌或其他属。益生菌可显著增加SM或LB的数目降低到104 CFU/mL以下的几率,对于SM,此程度的降低已得到了证实,但是对于LB还未确定。对于牙周致病菌,其数目的变化并不显著。益生菌可显著降低探针出血指数和牙龈指数,但是并不会明显降低菌斑指数。患龋率/龋经历以及临床附着水平并没有没有显著改善。相比之下,牙周袋探诊深度却明显降低。本研究所获得的数据定量不足以得出结论性的结果,偏倚的风险也很高。

从本研究的结果来看,目前的证据尚不足以推荐益生菌用于龋齿的管理,但支持使用益生菌用于牙龈炎或牙周炎的管理。未来的研究在记录公认的疾病标志物或指标时也应记录细菌的数量。

原始出处:

Gruner D, Paris S, Schwendicke F. Probiotics for managing caries and periodontitis: Systematic Review and Meta-Analysis. J Dent. 2016 Mar 7. pii: S0300-5712(16)30027-6. doi: 10.1016/j.jdent.2016.03.002.


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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

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    2016-09-13 ylzr123

    赞一个!好文章拜读了,认真学习了。

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    2016-08-02 1dd8c52fm63(暂无匿称)

    学习学习!

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    2016-04-07 xiaotaiyang1

    益生菌,研究越来越多了嘞

    0

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    2016-03-15 liuyong2982
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