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JAHA：类风湿性关节炎大鼠模型中房颤的促进作用

2017-12-29 xiangting MedSci原创

类风湿性关节炎房颤心律失常
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这项研究证实RA通过诱导AF促进心房重塑而增加AF易感性。

类风湿性关节炎（RA）患者中房颤（AF）的患病率明显升高，但其潜在机制仍不甚了解。这项研究的目的是在RA大鼠模型中评估RA对AF易感性和房性心律失常重塑的影响。

使用Freund不完全佐剂中的II型胶原免疫来引起大鼠胶原诱导的关节炎。在出现关节炎的大鼠中，初次免疫后8周检查AF易感性和心房重构。

AF诱导性和持续时间在胶原诱导关节炎大鼠中显著升高，AF持续时间与血清IL -6和TNF-α水平呈显著正相关。胶原诱导关节炎大鼠的心房传导时间延长，心房有效不应期无改变。心房传导延迟伴随心房纤维化的显著增多。此外，还观察到心房结构和自主神经重构，其中包括左心房扩张，心房肌细胞凋亡和自噬，心房异质性交感神经过度依赖。有趣的是，研究人员发现胶原诱导的关节炎对连接蛋白、Nav1.5以及心房中主要离子通道的蛋白表达没有明显影响。

这项研究证实RA通过诱导AF促进心房重塑而增加AF易感性。这项研究提供了深入了解RA诱导房颤的潜在机制，并验证了适合进一步机械和治疗性探索的模型。

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    2017-12-31 大爰

    学习了谢谢分享!!

    0

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    2017-12-31 lmm397

    #关节炎#

    0

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    2017-12-31 zhaohui6731

    #AHA#

    0

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    2017-12-31 ms4964546379600229

    #类风湿#

    0

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    2017-12-31 ms1467340776200723

    #风湿性关节炎#

    0

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    2017-12-29 惠映实验室

    学习了.谢谢

    0

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    2017-12-29 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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