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J Am Heart Assoc：维生素D能改善老年人血压、动脉硬化和心脏功能吗

2017-11-28 何娜 环球医学

维生素D老年人血压动脉硬化心脏功能
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2017年10月，发表在《J Am Heart Assoc》的BEST-D（Biochemical Efficacy and Safety Trial of Vitamin D，维生素D的生化功效和安全性试验）试验，考察了补充维生素D 1年对老年血压、动脉硬化和心脏功能的影响。

2017年10月，发表在《J Am Heart Assoc》的BEST-D（Biochemical Efficacy and Safety Trial of Vitamin D，维生素D的生化功效和安全性试验）试验，考察了补充维生素D 1年对老年血压、动脉硬化和心脏功能的影响。

背景：维生素D预防心血管疾病的相关性尚不确定。BEST-D试验既往报告过维生素D对血清维生素D水平的影响，本报告描述了维生素D对血压、心率、动脉硬化和心脏功能的影响。

方法和结果：本研究为一项随机、双盲、安慰剂对照试验，纳入居住在英国的305例老年人。这些人被分配至每日维生素D 4000 IU（100 μg）、维生素D 2000 IU（50 μg）或安慰剂组。主要结局为25-羟基维生素D血清浓度，次要结局为所有受试者6个月和12个月时的血压、心率和动脉硬化，12个月时的血清N末端脑钠肽前体水平，以及12个月时一个随机筛选亚组（n=177）的心脏功能超声心动图测量。基线平均（SE）血清25羟基维生素D浓度为50（SE 2）nmol/L，12个月后分配至维生素D 4000 IU/d、2000 IU/d或安慰剂的受试者分别增加至137（2.4）、102（2.4）和53（2.4）nmol/L。分配至维生素D组对6个月或12个月时的血压水平、心率或动脉硬化无显着影响，对心脏功能的超声心动图测量或12个月时血清N末端脑钠肽前体水平也没有显着影响。

结果：维生素D对血压、动脉硬化或心脏功能没有任何显着影响，表明维生素D不太可能通过这些机制对心血管疾病有任何获益影响.

原始出处：
Tomson J, Hin H, Emberson J,et al. Effects of Vitamin D on Blood Pressure, Arterial Stiffness, and Cardiac Function in Older People After 1?Year: BEST-D (Biochemical Efficacy and Safety Trial of Vitamin D).J Am Heart Assoc. 2017 Oct 24;6(10). pii: e005707. doi: 10.1161/JAHA.117.005707

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    2018-01-05 1dd8c52fm63(暂无匿称)

    了解了解.学习学习

    0

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    2017-11-30 zhaojie88

    #ART#

    0

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    2017-11-30 tidiq

    #心脏功能#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=275732, encodeId=22ed2e573237, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Jan 05 13:00:57 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356584, encodeId=be3a135658475, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Nov 30 04:29:00 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413774, encodeId=fd461413e74e6, content=<a href='/topic/show?id=3a96514459f' target=_blank style='color:#2F92EE;'>#心脏功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51445, encryptionId=3a96514459f, topicName=心脏功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a293020977, createdName=tidiq, createdTime=Thu Nov 30 04:29:00 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562753, encodeId=394f1562e53a7, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Nov 30 04:29:00 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
    2017-11-30 slcumt

    #HEART#

    0

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