2014 AHA/ACC/HRS 心房颤动患者管理指南

2014-03-30 MedSci MedSci原创

      近日,美国心脏学会(AHA)、美国心脏病学会(ACC)、心律学会(HRS)和胸外科学会联合发布了新版心房颤动患者管理指南(以下简称新版指南),代替了2006年版房颤指南和2项于2011年更新的指南,涵盖了部分2012年版欧洲房颤指南。指南全文3月28日同时在线发表于 《美国心脏病学杂志》(简称JACC)、《循环》(Circu

近日,美国心脏学会(AHA)、美国心脏病学会(ACC)、心律学会(HRS)和胸外科学会联合发布了新版心房颤动患者管理指南(以下简称新版指南),代替了2006年版房颤指南和2项于2011年更新的指南,涵盖了部分2012年版欧洲房颤指南。指南全文3月28日同时在线发表于 《美国心脏病学杂志》(JACC)、《循环》(Circulation)和《心律学》(Heart Rhythm)杂志。


新版指南作者写道,房颤与卒中风险增加5倍、心衰风险增加3倍、痴呆和死亡风险增加2倍有关。房颤的症状可从无到很严重,病情可能较为复杂并难以管理。

新版指南编写委员会主席Craig T January博士指出了该指南的以下4项显著变化。 

1、CHA2DS2-VASc代替CHADS2 

为评估非瓣膜性房颤患者的卒中危险,新版指南推荐综合性更强的CHA2DS2-VASc评分系统代替CHADS2评分系统。其中,充血性性心力衰竭(CHF)、高血压糖尿病、血管病变(有心肌梗死、周围血管病和动脉斑块病史)、年龄65—74岁、女性分别占1分,年龄≥75岁、既往发生 过卒中/短暂性脑缺血发作(TIA)/血栓栓塞分别占2分。

与CHADS2评分相比,CHA2DS2-VASc评分分数范围更广(0-9分),包含有更多的危险因素(女性、年龄65 —74岁和血管病变)。January认为,CHA2DS2-VASc评分可有助于更好的评估风险,尤其是低危人群。


2、阿司匹林地位下降

January指出,在减少卒中风险方面,房颤患者应用阿司匹林没有获益或获益较少,且有出血风险,因此新版指南的阿司匹林地位有所下降。

3、新型抗凝剂为治疗的新选择

之前指南推荐的抗凝剂只有华法林,在过去两年中,治疗非瓣膜性房颤的新型抗凝剂已进入市场,因此新版指南将新型抗凝剂也列入了推荐范围内。指南推荐,既往卒中、TIA或CHA2DS2-VASc评分≥2分非瓣膜性房颤患者均可应用新型口服抗凝剂。

治疗选择表

药物

证据级别

华法林(INR 2.0–3.0)

A级

达比加群

B级

利伐沙班

B级

阿哌沙班

B级


January 强调,费用为新型口服抗凝剂广泛应用的障碍。达比加群和利伐沙班禁用于终末期肾病或透析患者。阿哌沙班近期已获准用于透析患者,但还没有有关该药在这类患者中应用的临床经验。

4、导管消融地位凸显

新版指南第4项重要变化就是导管射频消融治疗发挥着越来越重要的作用,尤其是在症状非常明显的房颤患者中可作为主要治疗方法。在症状反复 发作的阵发性房颤患者中,临床医生在权衡药物和导管消融治疗利弊后,在抗心律失常药治疗前进行导管消融治疗是合理的初始心律控制策略。

更多的治疗方法尚在研究中

January表示,一些房颤管理的问题尚在解决中。比如, CHA2DS2-VASc评分为0的患者,很难说不需要抗凝剂的治疗,目前针对上述问题具体处理的证据尚不足。另外,对于CHA2DS2-VASc评分为 1的低危患者,是否可以用阿司匹林治疗,他们是否需要充分的抗凝治疗等问题还有待进一步研究来解决。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=35895, encodeId=931f35895c0, content=很好,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=88a91643785, createdName=zhuangjingpei, createdTime=Thu Aug 20 21:17:00 CST 2015, time=2015-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936268, encodeId=f4e0193626806, content=<a href='/topic/show?id=daa1e60387b' target=_blank style='color:#2F92EE;'>#管理指南#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76038, encryptionId=daa1e60387b, topicName=管理指南)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Tue Jan 06 13:12:00 CST 2015, time=2015-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10194, encodeId=4ca710194a5, content=CHA2DS2-VASc怎么读啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a03104789, createdName=lidage, createdTime=Sun Jun 29 22:39:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9531, encodeId=a3b495316a, content=很新的好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1ec102815, createdName=yuyudidadi, createdTime=Mon May 19 22:58:00 CST 2014, time=2014-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267205, encodeId=507b126e20518, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324887, encodeId=3949132488ebc, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464096, encodeId=193c14640968f, content=<a href='/topic/show?id=da7d9119bc' target=_blank style='color:#2F92EE;'>#HRS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9119, encryptionId=da7d9119bc, topicName=HRS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=259a6588710, createdName=ysjykql, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546023, encodeId=902515460232d, content=<a href='/topic/show?id=3e0453069aa' target=_blank style='color:#2F92EE;'>#患者管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53069, encryptionId=3e0453069aa, topicName=患者管理)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=179213855182, createdName=ms7421025882867189, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626791, encodeId=540f1626e91dc, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=)]
    2015-08-20 zhuangjingpei

    很好,谢谢!

    0

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    2014-06-29 lidage

    CHA2DS2-VASc怎么读啊

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=35895, encodeId=931f35895c0, content=很好,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=88a91643785, createdName=zhuangjingpei, createdTime=Thu Aug 20 21:17:00 CST 2015, time=2015-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936268, encodeId=f4e0193626806, content=<a href='/topic/show?id=daa1e60387b' target=_blank style='color:#2F92EE;'>#管理指南#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76038, encryptionId=daa1e60387b, topicName=管理指南)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Tue Jan 06 13:12:00 CST 2015, time=2015-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10194, encodeId=4ca710194a5, content=CHA2DS2-VASc怎么读啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a03104789, createdName=lidage, createdTime=Sun Jun 29 22:39:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9531, encodeId=a3b495316a, content=很新的好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1ec102815, createdName=yuyudidadi, createdTime=Mon May 19 22:58:00 CST 2014, time=2014-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267205, encodeId=507b126e20518, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324887, encodeId=3949132488ebc, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464096, encodeId=193c14640968f, content=<a href='/topic/show?id=da7d9119bc' target=_blank style='color:#2F92EE;'>#HRS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9119, encryptionId=da7d9119bc, topicName=HRS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=259a6588710, createdName=ysjykql, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546023, encodeId=902515460232d, content=<a href='/topic/show?id=3e0453069aa' target=_blank style='color:#2F92EE;'>#患者管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53069, encryptionId=3e0453069aa, topicName=患者管理)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=179213855182, createdName=ms7421025882867189, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626791, encodeId=540f1626e91dc, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=)]
    2014-05-19 yuyudidadi

    很新的好东西

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=35895, encodeId=931f35895c0, content=很好,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=88a91643785, createdName=zhuangjingpei, createdTime=Thu Aug 20 21:17:00 CST 2015, time=2015-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936268, encodeId=f4e0193626806, content=<a href='/topic/show?id=daa1e60387b' target=_blank style='color:#2F92EE;'>#管理指南#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76038, encryptionId=daa1e60387b, topicName=管理指南)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Tue Jan 06 13:12:00 CST 2015, time=2015-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10194, encodeId=4ca710194a5, content=CHA2DS2-VASc怎么读啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a03104789, createdName=lidage, createdTime=Sun Jun 29 22:39:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9531, encodeId=a3b495316a, content=很新的好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1ec102815, createdName=yuyudidadi, createdTime=Mon May 19 22:58:00 CST 2014, time=2014-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267205, encodeId=507b126e20518, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324887, encodeId=3949132488ebc, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464096, encodeId=193c14640968f, content=<a href='/topic/show?id=da7d9119bc' target=_blank style='color:#2F92EE;'>#HRS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9119, encryptionId=da7d9119bc, topicName=HRS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=259a6588710, createdName=ysjykql, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546023, encodeId=902515460232d, content=<a href='/topic/show?id=3e0453069aa' target=_blank style='color:#2F92EE;'>#患者管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53069, encryptionId=3e0453069aa, topicName=患者管理)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=179213855182, createdName=ms7421025882867189, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626791, encodeId=540f1626e91dc, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=)]
    2014-04-01 zhaohui6731
  6. [GetPortalCommentsPageByObjectIdResponse(id=35895, encodeId=931f35895c0, content=很好,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=88a91643785, createdName=zhuangjingpei, createdTime=Thu Aug 20 21:17:00 CST 2015, time=2015-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936268, encodeId=f4e0193626806, content=<a href='/topic/show?id=daa1e60387b' target=_blank style='color:#2F92EE;'>#管理指南#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76038, encryptionId=daa1e60387b, topicName=管理指南)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Tue Jan 06 13:12:00 CST 2015, time=2015-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10194, encodeId=4ca710194a5, content=CHA2DS2-VASc怎么读啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a03104789, createdName=lidage, createdTime=Sun Jun 29 22:39:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9531, encodeId=a3b495316a, content=很新的好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1ec102815, createdName=yuyudidadi, createdTime=Mon May 19 22:58:00 CST 2014, time=2014-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267205, encodeId=507b126e20518, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324887, encodeId=3949132488ebc, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464096, encodeId=193c14640968f, content=<a href='/topic/show?id=da7d9119bc' target=_blank style='color:#2F92EE;'>#HRS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9119, encryptionId=da7d9119bc, topicName=HRS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=259a6588710, createdName=ysjykql, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546023, encodeId=902515460232d, content=<a href='/topic/show?id=3e0453069aa' target=_blank style='color:#2F92EE;'>#患者管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53069, encryptionId=3e0453069aa, topicName=患者管理)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=179213855182, createdName=ms7421025882867189, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626791, encodeId=540f1626e91dc, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=35895, encodeId=931f35895c0, content=很好,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=88a91643785, createdName=zhuangjingpei, createdTime=Thu Aug 20 21:17:00 CST 2015, time=2015-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936268, encodeId=f4e0193626806, content=<a href='/topic/show?id=daa1e60387b' target=_blank style='color:#2F92EE;'>#管理指南#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76038, encryptionId=daa1e60387b, topicName=管理指南)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Tue Jan 06 13:12:00 CST 2015, time=2015-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10194, encodeId=4ca710194a5, content=CHA2DS2-VASc怎么读啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a03104789, createdName=lidage, createdTime=Sun Jun 29 22:39:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9531, encodeId=a3b495316a, content=很新的好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1ec102815, createdName=yuyudidadi, createdTime=Mon May 19 22:58:00 CST 2014, time=2014-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267205, encodeId=507b126e20518, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324887, encodeId=3949132488ebc, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464096, encodeId=193c14640968f, content=<a href='/topic/show?id=da7d9119bc' target=_blank style='color:#2F92EE;'>#HRS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9119, encryptionId=da7d9119bc, topicName=HRS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=259a6588710, createdName=ysjykql, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546023, encodeId=902515460232d, content=<a href='/topic/show?id=3e0453069aa' target=_blank style='color:#2F92EE;'>#患者管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53069, encryptionId=3e0453069aa, topicName=患者管理)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=179213855182, createdName=ms7421025882867189, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626791, encodeId=540f1626e91dc, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=)]
    2014-04-01 ysjykql
  8. [GetPortalCommentsPageByObjectIdResponse(id=35895, encodeId=931f35895c0, content=很好,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=88a91643785, createdName=zhuangjingpei, createdTime=Thu Aug 20 21:17:00 CST 2015, time=2015-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936268, encodeId=f4e0193626806, content=<a href='/topic/show?id=daa1e60387b' target=_blank style='color:#2F92EE;'>#管理指南#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76038, encryptionId=daa1e60387b, topicName=管理指南)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Tue Jan 06 13:12:00 CST 2015, time=2015-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10194, encodeId=4ca710194a5, content=CHA2DS2-VASc怎么读啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a03104789, createdName=lidage, createdTime=Sun Jun 29 22:39:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9531, encodeId=a3b495316a, content=很新的好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1ec102815, createdName=yuyudidadi, createdTime=Mon May 19 22:58:00 CST 2014, time=2014-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267205, encodeId=507b126e20518, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324887, encodeId=3949132488ebc, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464096, encodeId=193c14640968f, content=<a href='/topic/show?id=da7d9119bc' target=_blank style='color:#2F92EE;'>#HRS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9119, encryptionId=da7d9119bc, topicName=HRS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=259a6588710, createdName=ysjykql, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546023, encodeId=902515460232d, content=<a href='/topic/show?id=3e0453069aa' target=_blank style='color:#2F92EE;'>#患者管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53069, encryptionId=3e0453069aa, topicName=患者管理)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=179213855182, createdName=ms7421025882867189, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626791, encodeId=540f1626e91dc, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Apr 01 10:12:00 CST 2014, time=2014-04-01, status=1, ipAttribution=)]
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    2014-04-01 sodoo

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