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JCO：家族性结直肠癌的人体应几年行一次结肠镜筛查？3年还是6年？

2015-11-09 Seven L 译 MedSci原创

家族性结直肠癌结肠镜筛查腺癌
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对有家族性结直肠癌(CRC)史的个体应进行定期的结肠镜检查，那么这个时间间隔是多久？研究者进行了一项研究，探究间隔3年和6年对筛查的影响。该研究纳入了45-65岁、一级亲属有一名年龄＜50岁的CRC或有两名二级亲属患CRC的0-2级腺瘤患者，随机分为A组（第6年进行结肠镜检查）和B组（第3年、第6年进行结肠镜检查）。该研究共纳入528名患者，A组有262人，B组有266人。ITT分析显示，A组第6

对有家族性结直肠癌(CRC)史的个体应进行定期的结肠镜检查，那么这个时间间隔是多久？研究者进行了一项研究，探究间隔3年和6年对筛查的影响。

该研究纳入了45-65岁、一级亲属有一名年龄＜50岁的CRC或有两名二级亲属患CRC的0-2级腺瘤患者，随机分为A组（第6年进行结肠镜检查）和B组（第3年、第6年进行结肠镜检查）。

该研究共纳入528名患者，A组有262人，B组有266人。ITT分析显示，A组第6年筛查和B组第3年筛查，晚期腺瘤息肉（AAPs）患者比例无显著差异（A vs B：6.9% vs 3.5%）；第6年时，A、B两组AAPs患者比例仍无显著差异（6.9% vs 3.4%）。研究者发现两组不管是第一次筛查还是对方的最后，只有基线资料的差异具有统计学意义。

该研究随访6年，A组的AAPs发生率很低，且没有CRC发生，因此研究者认为对该类人群进行6年一次结肠镜筛查比较合适，伴有AAPs和3级腺瘤患者则进行每3年一次的筛查。

原始出处：

Hennink SD, van der Meulen-de Jong AE,et al.Randomized Comparison of Surveillance Intervals in Familial Colorectal Cancer.J Clin Oncol. 2015 Nov 2.


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    2016-03-14 lidong40

    #JCO#

    0

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    2016-01-26 I come

    难受

    0

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    2015-12-29 xyfg98

    要学习

    0

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    2015-11-11 zhouqu_8

    #肠镜#

    0

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    2015-11-11 crystal0564

    #结直肠#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1891223, encodeId=eccc189122344, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Mon Mar 14 13:02:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59712, encodeId=c44f59e12c8, content=难受, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue Jan 26 16:45:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50245, encodeId=d3ff502453e, content=要学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Dec 29 15:48:00 CST 2015, time=2015-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434418, encodeId=dfc514344186d, content=<a href='/topic/show?id=95de81e4889' target=_blank style='color:#2F92EE;'>#肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81748, encryptionId=95de81e4889, topicName=肠镜)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Nov 11 13:02:00 CST 2015, time=2015-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452774, encodeId=09061452e74d8, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Wed Nov 11 13:02:00 CST 2015, time=2015-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629474, encodeId=169d16294e41d, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26fc21339997, createdName=wetgdt, createdTime=Wed Nov 11 13:02:00 CST 2015, time=2015-11-11, status=1, ipAttribution=)]
    2015-11-11 wetgdt

    #家族性#

    0