JAMA Oncology:摄入纤维与结直肠癌患者生存的关系

2017-11-03 MedSci MedSci原创

尽管膳食纤维摄入增加与结直肠癌发病率降低有关,但是纤维是否会影响结直肠癌患者远期生存是缺乏研究。JAMA Oncology近期发表了一篇文章,研究结直肠癌确诊后纤维摄入与患者死亡之间的关系。

尽管膳食纤维摄入增加与结直肠癌发病率降低有关,但是纤维是否会影响结直肠癌患者远期生存是缺乏研究。JAMA Oncology近期发表了一篇文章,研究结直肠癌确诊后纤维摄入与患者死亡之间的关系。研究共评估了2个前瞻性队列共1575例Ⅰ-Ⅲ期结直肠癌患者。调整了其他可能影响肿瘤生存的影响因素后研究结直肠肿瘤特异性生存和总生存率。在纳入的1575例患者中,女性963例,平均年龄68.6岁。在平均8年的随访周期中,有记录的死亡共773例,其中174例是由于结直肠癌死亡。肿瘤确诊后膳食纤维摄入增加与死亡率降低有关。每天纤维摄入量每增加5g对结直肠癌特异性死亡率的HR值为0.78,对总死亡率的HR值为0.86。确诊后较确诊前纤维摄入增加的患者死亡率更低,每5g/d摄入增加与18%结直肠特异性死亡率降低以及14%总死亡率降低有关。就纤维来源而言,谷物纤维与更低的结直肠癌特异性死亡率和总死亡率有关。蔬菜纤维与更低的总死亡率有关,但是与结直肠癌特异性死亡无关。水果纤维并未观察到与死亡率之间的关系。全谷物摄入与结直肠癌特异性死亡率降低有关,这种有益效果在调整了纤维摄入后出现衰减。文章最后认为,非转移性结直肠

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    2018-04-22 minlingfeng
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    2017-12-09 杨柳青青

    签到学习了--

    0

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    2017-11-03 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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    2017-11-03 榄枷檬

    谢谢分享

    0

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    2017-11-03 榄枷檬

    学习学习

    0

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