NEJM:血吸虫根除计划效果评估

2019-12-26 MedSci MedSci原创

研究表明,密切监控和评估各国血吸虫病控制方案的效果并做出针对性的调整,是早日实现血吸虫根除的必要手段。

血吸虫病是一个严重的公共卫生问题,WHO计划于2020-2025年间有效控制并彻底消除血吸虫病。

近日,研究人员就9个国家血吸虫病防治项目(8个撒哈拉以南非洲国家和也门)多年横断面数据进行考察。根据血吸虫种类(曼氏血吸虫或埃及血吸虫)、治疗轮数、总体流行率和严重感染率对数据进行分析。疾病控制定义为严重感染率低于5%,消除定义为严重患病率小于1%。严重感染定义为每克粪便中至少有400个曼氏虫卵,或每10毫升尿液中至少有50个埃及血吸虫卵。

除尼日尔之外,其他国家都通过两轮或更少的治疗达到了疾病控制目标,这比世卫组织现行标准(5至10年)的预测要早。与基线时具有中高流行性的地区相比,低流行性地区的项目更有可能达到疾病控制或疾病消除的目标,虽然仅实现了埃及血吸虫消除目标(布基纳法索、布隆迪和卢旺达分三轮治疗)。不同国家间在总体流行率和重度感染的差异显著,难以使用同个标准评判疾病的控制或消除。

研究表明,密切监控和评估各国血吸虫病控制方案的效果并做出针对性的调整,是早日实现血吸虫根除的必要手段。

原始出处:

Arminder K. Deolet al. Schistosomiasis - Assessing Progress toward the 2020 and 2025 Global Goals. N Engl J Med, December 26, 2019.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1890934, encodeId=959218909340e, content=<a href='/topic/show?id=84505e5207c' target=_blank style='color:#2F92EE;'>#效果评估#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57520, encryptionId=84505e5207c, topicName=效果评估)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Mar 30 20:59:00 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683697, encodeId=0250168369e8d, content=<a href='/topic/show?id=c2fc6228167' target=_blank style='color:#2F92EE;'>#根除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62281, encryptionId=c2fc6228167, topicName=根除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07d627990740, createdName=风铃830, createdTime=Sat Jul 04 08:59:00 CST 2020, time=2020-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428872, encodeId=c22514288e26a, content=<a href='/topic/show?id=ce5a8898902' target=_blank style='color:#2F92EE;'>#血吸虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88989, encryptionId=ce5a8898902, topicName=血吸虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38144138896, createdName=ylz8404, createdTime=Sat Dec 28 09:59:00 CST 2019, time=2019-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035066, encodeId=d1c010350664c, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Dec 26 21:59:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046969, encodeId=f815104696901, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Dec 26 21:59:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1890934, encodeId=959218909340e, content=<a href='/topic/show?id=84505e5207c' target=_blank style='color:#2F92EE;'>#效果评估#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57520, encryptionId=84505e5207c, topicName=效果评估)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Mar 30 20:59:00 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683697, encodeId=0250168369e8d, content=<a href='/topic/show?id=c2fc6228167' target=_blank style='color:#2F92EE;'>#根除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62281, encryptionId=c2fc6228167, topicName=根除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07d627990740, createdName=风铃830, createdTime=Sat Jul 04 08:59:00 CST 2020, time=2020-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428872, encodeId=c22514288e26a, content=<a href='/topic/show?id=ce5a8898902' target=_blank style='color:#2F92EE;'>#血吸虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88989, encryptionId=ce5a8898902, topicName=血吸虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38144138896, createdName=ylz8404, createdTime=Sat Dec 28 09:59:00 CST 2019, time=2019-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035066, encodeId=d1c010350664c, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Dec 26 21:59:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046969, encodeId=f815104696901, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Dec 26 21:59:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2020-07-04 风铃830
  3. [GetPortalCommentsPageByObjectIdResponse(id=1890934, encodeId=959218909340e, content=<a href='/topic/show?id=84505e5207c' target=_blank style='color:#2F92EE;'>#效果评估#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57520, encryptionId=84505e5207c, topicName=效果评估)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Mar 30 20:59:00 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683697, encodeId=0250168369e8d, content=<a href='/topic/show?id=c2fc6228167' target=_blank style='color:#2F92EE;'>#根除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62281, encryptionId=c2fc6228167, topicName=根除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07d627990740, createdName=风铃830, createdTime=Sat Jul 04 08:59:00 CST 2020, time=2020-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428872, encodeId=c22514288e26a, content=<a href='/topic/show?id=ce5a8898902' target=_blank style='color:#2F92EE;'>#血吸虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88989, encryptionId=ce5a8898902, topicName=血吸虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38144138896, createdName=ylz8404, createdTime=Sat Dec 28 09:59:00 CST 2019, time=2019-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035066, encodeId=d1c010350664c, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Dec 26 21:59:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046969, encodeId=f815104696901, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Dec 26 21:59:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2019-12-28 ylz8404
  4. [GetPortalCommentsPageByObjectIdResponse(id=1890934, encodeId=959218909340e, content=<a href='/topic/show?id=84505e5207c' target=_blank style='color:#2F92EE;'>#效果评估#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57520, encryptionId=84505e5207c, topicName=效果评估)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Mar 30 20:59:00 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683697, encodeId=0250168369e8d, content=<a href='/topic/show?id=c2fc6228167' target=_blank style='color:#2F92EE;'>#根除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62281, encryptionId=c2fc6228167, topicName=根除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07d627990740, createdName=风铃830, createdTime=Sat Jul 04 08:59:00 CST 2020, time=2020-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428872, encodeId=c22514288e26a, content=<a href='/topic/show?id=ce5a8898902' target=_blank style='color:#2F92EE;'>#血吸虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88989, encryptionId=ce5a8898902, topicName=血吸虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38144138896, createdName=ylz8404, createdTime=Sat Dec 28 09:59:00 CST 2019, time=2019-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035066, encodeId=d1c010350664c, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Dec 26 21:59:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046969, encodeId=f815104696901, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Dec 26 21:59:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2019-12-26 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1890934, encodeId=959218909340e, content=<a href='/topic/show?id=84505e5207c' target=_blank style='color:#2F92EE;'>#效果评估#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57520, encryptionId=84505e5207c, topicName=效果评估)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Mar 30 20:59:00 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683697, encodeId=0250168369e8d, content=<a href='/topic/show?id=c2fc6228167' target=_blank style='color:#2F92EE;'>#根除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62281, encryptionId=c2fc6228167, topicName=根除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07d627990740, createdName=风铃830, createdTime=Sat Jul 04 08:59:00 CST 2020, time=2020-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428872, encodeId=c22514288e26a, content=<a href='/topic/show?id=ce5a8898902' target=_blank style='color:#2F92EE;'>#血吸虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88989, encryptionId=ce5a8898902, topicName=血吸虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38144138896, createdName=ylz8404, createdTime=Sat Dec 28 09:59:00 CST 2019, time=2019-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035066, encodeId=d1c010350664c, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Dec 26 21:59:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046969, encodeId=f815104696901, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Dec 26 21:59:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2019-12-26 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

相关资讯

江西建血吸虫病防治联合体

江西省环鄱阳湖血吸虫病防治科研联合体日前成立。该联合体由江西省寄生虫病防治研究所、南昌市第九医院牵头,该省30个县(市、区)血吸虫病防治站共同加盟,打造共建共享发展平台。

Sci Rep:泌尿道和胆道上皮细胞对埃及血吸虫和曼氏血吸虫虫卵的不同响应研究

慢性泌尿生殖道血吸虫病能够导致膀胱鳞状细胞癌。国际癌症研究机构将感染的血链球菌归为一类致癌物,并且是导致癌症的一个明确原因。相反,由于慢性感染与肝门脉周围纤维化相关的曼氏血吸虫或者日本血吸虫导致的肝肠血吸虫病却不能明显的导致恶性肿瘤的产生。最近,有研究人员调查了来自于正常膀胱上皮的HCV29培养人类上皮细胞以及来自胆管的培养人类上皮细胞H69对血吸虫和曼氏血吸虫虫卵的响应情况。研究人员将血吸虫卵与

Elife:操纵CRISPR/Cas9“驯化”寄生虫病

乔治华盛顿大学的研究人员首次与泰国、澳大利亚、英国和荷兰等地的研究机构的同事一起通过CRISPR/Cas9技术遏制了血吸虫病和肝吸虫感染,成果发表在eLife杂志。

PNAS:血吸虫病肝纤维化调控新机制

血吸虫病是一种古老热带传染病,其主要病变是引起肝维化。研究已表明肝星状细胞(HSC)是肝纤维化的主要效应细胞,其活化可转化为肌成纤维细胞,并分泌胶原蛋白引起肝纤维化。近日,由海军军医大学潘卫庆教授领衔的研究团队,研究发现了一种微小RNA(miR-351)可调控HSC的活化从而促进血吸虫病肝纤维化的发生和发展,并阐明了miR-351表达及其调控作用的分子机制,相关研究结果近日在线发表在国际著名期刊《

Science:为获取疫苗探路,17名志愿者让血吸虫钻入体内

在非洲、中东和拉丁美洲,数百万人患有血吸虫病,每年的致死人数则达上***。目前,能与该疾病对抗的只有一种很老且效果不佳的药物——吡喹酮。荷兰的一个实验室从2017年开始,试图通过血吸虫人体感染实验来获得疫苗。

志愿者感染血吸虫加速药物研发

2月的一个周四中午12点05分,一名实验室技术人员取下含有一只独栖红螺的六孔板,并将其浸入在强光下加热的水槽中。光照和温暖预示着上百只微小的寄生虫幼虫将从这只软体动物中涌出。现在,对于荷兰莱顿大学医学中心传染病医生Meta Roestenberg来说,计时已经开始。她有约4个小时的时间开展一项独特但具有争议性的试验。在该试验中,Roestenberg将让这些寄生虫钻入4名健康志愿者的手臂。如果等待