JAMA Surg:胃肠道手术术前糖化血红蛋白水平,术后48小时血糖与预后不良的关系

2017-07-29 zhangfan MedSci原创

研究发现,术后48小时内血糖升高会增加肠胃道术后患者再入院率,但术前糖化血红蛋白水平升高会降低患者再入院率。术前糖化血红蛋白水平与术后血糖检查频率以及胰岛素使用相关,该现象说明严密的术后监控以及药物控制是降低患者并发症的有效方法。

术前高血糖与患者术后不良结局相关。近日研究人员考察了术前糖化血红蛋白和术后早期血糖水平与患者术后并发症和再入院风险的关系。

研究人员对2007-14年间,117个退伍军人事务医院进行的胃肠外科手术资料进行分析总结。术前糖化血红蛋白(HbA1c)水平分为3个层次(<5.7%, 5.7%-6.5%以及>6.5%)。采用逻辑回归分析考察术前HbA1c以及术后48小时最高血糖水平与30天再入院率和不良事件的关系。

共21541名患者参与本次研究,其中女性1193人,患者平均年龄63.7岁。 研究队列中共23094人进行了术前HbA1c以及术后血糖测试。总的并发症以及30天再入院率分别为27.2%和14.7%。在对HbA1c、术后血糖水平、术后胰岛素的使用、糖尿病、BMI以及其他患者和操作因素进行调整后,术后血糖峰值超过250 mg/dL可增加30天再入院风险(OR 1.18; 95% CI, 0.99-1.41; P=0.07),而术前 HbA1c水平高于6.5% 可降低30天的再入院风险(OR, 0.85; 95% CI, 0.74-0.96; P=0.01)。术前糖化血红蛋白增加, 术后48小时血糖检查的频率增加( HbA1c <5.7%, 5.7%-6.4%以及>6.5%的检查频率分别为4.92次, 6.89次, 以及9.71次;P<0.001)。HbA1c 水平超过6.5% 导致术后胰岛素使用增加。

研究发现,术后48小时内血糖升高会增加肠胃道术后患者再入院率,但术前糖化血红蛋白水平升高会降低患者再入院率。术前糖化血红蛋白水平与术后血糖检查频率以及胰岛素使用相关,该现象说明严密的术后监控以及药物控制是降低患者并发症的有效方法。

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    2017-07-31 虈亣靌

    学习了学习了,非常感谢分享

    0

  3. 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    2017-07-31 liao1619
  4. 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  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sat Jul 29 09:24:28 CST 2017, time=2017-07-29, status=1, ipAttribution=)]
    2017-07-29 131****1460

    学习了受益匪浅。

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Sat Jul 29 15:40:20 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227703, encodeId=b48e22e703da, content=控制好血糖,有利手术恢复。, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jul 29 15:04:10 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227636, encodeId=eca222e6361c, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jul 29 10:30:13 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227611, encodeId=404622e611b0, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Jul 29 09:25:33 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227609, encodeId=a6b122e609a4, content=很实用的讲解, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sat Jul 29 09:24:28 CST 2017, time=2017-07-29, status=1, ipAttribution=)]
    2017-07-29 137****9095

    henhao

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sat Jul 29 09:24:28 CST 2017, time=2017-07-29, status=1, ipAttribution=)]
    2017-07-29 1e0f8808m18(暂无匿称)

    控制好血糖,有利手术恢复。

    0

  8. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Sat Jul 29 15:40:20 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227703, encodeId=b48e22e703da, content=控制好血糖,有利手术恢复。, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jul 29 15:04:10 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227636, encodeId=eca222e6361c, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jul 29 10:30:13 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227611, encodeId=404622e611b0, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Jul 29 09:25:33 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227609, encodeId=a6b122e609a4, content=很实用的讲解, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sat Jul 29 09:24:28 CST 2017, time=2017-07-29, status=1, ipAttribution=)]
    2017-07-29 Y—xianghai

    学习了新知识

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1766754, encodeId=575c1e66754f5, content=<a href='/topic/show?id=257d8168248' target=_blank style='color:#2F92EE;'>#肠道手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81682, encryptionId=257d8168248, topicName=肠道手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=352d37864233, createdName=12498e5fm24(暂无昵称), createdTime=Tue Jan 23 12:10:00 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228492, encodeId=9bae22849267, content=学习了学习了,非常感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Sat Jul 29 15:40:20 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227703, encodeId=b48e22e703da, content=控制好血糖,有利手术恢复。, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jul 29 15:04:10 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227636, encodeId=eca222e6361c, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jul 29 10:30:13 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227611, encodeId=404622e611b0, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Jul 29 09:25:33 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227609, encodeId=a6b122e609a4, content=很实用的讲解, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sat Jul 29 09:24:28 CST 2017, time=2017-07-29, status=1, ipAttribution=)]
    2017-07-29 明月清辉

    谢谢分享,学习了

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sat Jul 29 09:24:28 CST 2017, time=2017-07-29, status=1, ipAttribution=)]
    2017-07-29 楠博One

    很实用的讲解

    0

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随着糖尿病发病率的增高,合并外科疾病且需外科手术治疗的也日益增多。与非糖尿病人相比,糖尿病患者由于存在糖代谢紊乱及伴随疾病,其手术风险要大得多——手术应激可使血糖急剧升高,造成糖尿病急性并发症发生率增加,这也是术后病死率增加的主要原因之一;另外,高血糖可造成感染发生率增加及伤口愈合延迟。

Crit Care:重症护理中的血糖和死亡率研究

高血糖与重症监护病房中患者的不良结局相关,已有研究提出了对血糖控制(GC)的益处。然而,随后的一些研究往往无法复制这些结果,而且往往无法实现一致的、安全的血糖控制、GC的益处或危害的问题以及糖尿病与死亡率和临床结果的相关性。近期,一项发表在杂志Crit Care上的研究评估了未生存者是否比生存者更难控制血糖,并确定了血糖结果是否对患者的状况和最终结局发挥作用。此项研究选取了145名患者(119名生

World J Diabetes:牙周炎可影响机体的血糖水平

本研究旨在探讨牙周非手术治疗对伴慢性牙周炎的糖尿病前期患者(CHP)的糖化血红蛋白水平的影响。研究纳入了60名糖尿病前期患者,并匹配病例组和对照组。基线时期评估所有受试者的牙周参数(牙周指数、口腔卫生指数、改良牙龈指数、探诊深度、临床附着水平)和全身参数(糖化血红蛋白(HbA1c)、空腹血脂和空腹血糖)。病例组接受非手术牙周治疗。三个月后重新评估受试者的牙周和全身参数。结果,两组受试者在基线时各种

Cell Host Microbe:又一个容易被忽视的糖尿病并发症!

宾夕法尼亚大学研究人员发起的一项新研究发现口腔微生物组织受糖尿病影响,导致其致病性增加。本周发表在Cell Host&Microbe杂志上的研究不仅表明糖尿病小鼠的口腔微生物组织转移,而且这种变化与炎症和骨丢失增加有关。

Neurology:2型糖尿病、血糖、胰岛素、体重指数和缺血性卒中亚型相关性分析!

由此可见,该研究支持T2D可能与大血管卒中存在因果关系。