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Neurology：TIA或卒中后，Lp-PLA2-A增高会增加短期血管事件

2015-09-24 phylis 译 MedSci原创

Lp-PLA2-A轻微卒中TIA
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目的：调查TIA或轻微卒中患者急性期脂蛋白相关磷脂酶A2（Lp-PLA2）与短期血管事件再发风险的关系。方法：研究人员从CHANCE（氯吡格雷在急性非致残性脑血管事件高危患者中的应用）试验中招募的3201名受试者Lp-PLA2活性（Lp-PLA2-A）。招募症状开始在24h内TIA或轻微卒中的受试者，并将其随机进行单一或者联合抗血小板治疗。在最近的分析中，主要预后为90天内发生缺血性卒中，心肌梗死

目的：调查TIA或轻微卒中患者急性期脂蛋白相关磷脂酶A2（Lp-PLA2）与短期血管事件再发风险的关系。

方法：研究人员从CHANCE（氯吡格雷在急性非致残性脑血管事件高危患者中的应用）试验中招募的3201名受试者Lp-PLA2活性（Lp-PLA2-A）。招募症状开始在24h内TIA或轻微卒中的受试者，并将其随机进行单一或者联合抗血小板治疗。在最近的分析中，主要预后为90天内发生缺血性卒中，心肌梗死或者死亡。

结果：有299/3021（9.9%）名患者发生不良预后。Lp-PLA2-A的平均水平为209 ± 59 nmol/min/mL(95%CI: 207-211）。高龄、男性、当前吸烟与高Lp-PLA2-A水平相关。Lp-PLA2-A与主要预后密切相关（每增加30 nmol/min/mL校正HR：1.07， 95%CI 1.01-1.13）。在缺血性卒中的患者中也存在相似的结果。校正低密度脂蛋白胆固醇能够缓解Lp-PLA2-A与主要预后之间的关系（每增加30 nmol/min/mL校正HR：1.04, 95%CI:0.97-1.11）。

结论：急性期Lp-PLA2-A水平升高与短期内再发血管事件的风险相关。

原文出处：

Lin J, Zheng H, Cucchiara BL,et al. Association of Lp-PLA2-A and early recurrence of vascular events after TIA and minor stroke.Neurology. 2015 Aug 26


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    2016-05-17 智慧医人

    #PLA2#

    0

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    2015-11-17 waiwai3039

    #卒中后#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1789104, encodeId=81bc1e8910480, content=<a href='/topic/show?id=34871434005' target=_blank style='color:#2F92EE;'>#PLA2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14340, encryptionId=34871434005, topicName=PLA2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue May 17 22:41:00 CST 2016, time=2016-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671196, encodeId=a5d416e119659, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Tue Nov 17 00:41:00 CST 2015, time=2015-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643376, encodeId=ab8016433e6f8, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Tue Oct 20 10:41:00 CST 2015, time=2015-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999567, encodeId=aa7b199956ef4, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Jun 07 03:41:00 CST 2016, time=2016-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561571, encodeId=403f15615e13d, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sat Sep 26 11:41:00 CST 2015, time=2015-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567580, encodeId=5468156e580c2, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sat Sep 26 11:41:00 CST 2015, time=2015-09-26, status=1, ipAttribution=)]
    2015-10-20 hukaixun

    #血管事件#

    0

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    2016-06-07 yinhl1978

    #Neurol#

    0

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    2015-09-26 liuxiaona

    #增高#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1789104, encodeId=81bc1e8910480, content=<a href='/topic/show?id=34871434005' target=_blank style='color:#2F92EE;'>#PLA2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14340, encryptionId=34871434005, topicName=PLA2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue May 17 22:41:00 CST 2016, time=2016-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671196, encodeId=a5d416e119659, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Tue Nov 17 00:41:00 CST 2015, time=2015-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643376, encodeId=ab8016433e6f8, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Tue Oct 20 10:41:00 CST 2015, time=2015-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999567, encodeId=aa7b199956ef4, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Jun 07 03:41:00 CST 2016, time=2016-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561571, encodeId=403f15615e13d, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sat Sep 26 11:41:00 CST 2015, time=2015-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567580, encodeId=5468156e580c2, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sat Sep 26 11:41:00 CST 2015, time=2015-09-26, status=1, ipAttribution=)]
    2015-09-26 liuxiaona

    #增高#

    0