Arthritis Rheumatol:睡眠呼吸暂停患者的痛风风险

2018-09-02 xiangting MedSci原创

OSA患者在OSA诊断第一年后患痛风的风险仍然较高。痛风的高峰发病率随BMI的不同而有所变化。

阻塞性睡眠呼吸暂停(OSA)与一系列的严重并发症相关。这项研究探讨了在短期和长期内OSA患者是否比非OSA患者更容易患痛风。

这是一项在英国临床实践研究数据链中进行的匹配回顾性队列研究。确定年龄≥18岁并在1990年至2010年间诊断为OSA的个体,并根据年龄、性别和实际情况与多达4名非OSA个体进行匹配。随访至2015年底。调整一般健康状况、生活方式和合并症特征后,使用Cox回归估算危险比(HR)。在不同时间点评估偶发性痛风的风险,并呈现不同BMI分类的特定结果。

研究样本包括15,879名OSA患者和63,296名非OSA患者;中位随访时间为5.8年。4.9%的OSA患者和2.6%的非OSA患者出现痛风。OSA患者和非OSA患者每1000人年的发病率分别为7.83(95%CI 7.29,8.40)和4.03(3.84,4.23);调整后的HR为1.42(1.29,1.56)。与非OSA患者相比,OSA患者的痛风风险在指数日期后的1到2年最高(1.64(1.30,2.06))。在超重和肥胖患者中也是如此。对于BMI正常的患者,指数日期后2至5年的HR最高为2.02(1.13,3.62)。

OSA患者在OSA诊断第一年后患痛风的风险仍然较高。痛风的高峰发病率随BMI的不同而有所变化。

原始出处:
Milica Blagojevic‐Bucknall,et al. The risk of gout among patients with sleep apnea: a matched cohort study. Arthritis Rheumatol. 30 August 2018.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1972529, encodeId=82db19e252934, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Tue Sep 25 02:00:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342865, encodeId=421734286593, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/f3d88083d8829740786bed95c22464d1/e325f3af93bb747a620d16c209094d69.jpg, createdBy=9efb2014947, createdName=小小小麦兜, createdTime=Wed Sep 05 07:41:55 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989096, encodeId=7db31989096f7, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Sat Jan 12 04:00:00 CST 2019, time=2019-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342597, encodeId=7b3b34259e12, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Tue Sep 04 08:19:07 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356910, encodeId=69a713569109b, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Sep 04 01:00:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596539, encodeId=f59e159653980, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Tue Sep 04 01:00:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342270, encodeId=70d83422e055, content=痛风的患病率, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sun Sep 02 10:23:48 CST 2018, time=2018-09-02, status=1, ipAttribution=)]
    2018-09-05 小小小麦兜

    学习了

    0

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    2018-09-04 一天没事干

    很好的学习机会

    0

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    2018-09-04 zhaojie88
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    2018-09-02 flysky120

    痛风的患病率

    0

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