Ann Intern Med:莪术提取物治疗膝关节炎症状和积液性滑膜炎的效果

2021-04-17 MedSci原创 MedSci原创

目前骨关节炎患者的药物治疗方法均不理想。近日,一项随机、双盲、安慰剂对照试验测定了莪术提取物(CL)对有症状的膝关节骨关节炎和膝关节积液-滑膜炎患者减轻膝关节症状的疗效,研究结果已发表于Ann Int

目前骨关节炎患者的药物治疗方法均不理想。近日,一项随机、双盲、安慰剂对照试验测定了莪术提取物(CL)对有症状的膝关节骨关节炎和膝关节积液-滑膜炎患者减轻膝关节症状的疗效,研究结果已发表于Ann Intern Med。

研究纳入了 70名有症状的膝关节炎和超声检查确定的积液 -滑膜炎的参与者,随机分组分别接受每天2粒CL(n = 36)或匹配的安慰剂(n = 34),持续12周。2个主要结果是视觉模拟量表(VAS)膝关节疼痛变化和磁共振成像(MRI)显示的积液-滑膜炎体积变化。次要结果是西安大略省和麦克马斯特大学骨关节炎指数(WOMAC)疼痛和软骨成分值的变化。

 

结果显示,与安慰剂相比,CL将VAS疼痛改善了-9.1 mm(95% CI,-17.8至-0.4 mm [P = 0.039]),但没有改变积液-滑膜炎体积(3.2 mL [CI,-0.3至6.8 mL])。此外,CL还改善了WOMAC膝关节疼痛(-47.2 mm [CI,-81.2至-13.2 mm];P = 0.006),但没有改善股骨侧软骨T2松弛时间(-0.4 ms [CI,-1.1至0.3 ms])。CL(n = 14 [39%])和安慰剂(n = 18 [53%])组的不良事件发生率相似(P = 0.16);CL组的2个不良事件和安慰剂组的5个不良事件可能与治疗相关。

综上所述,该研究结果表明,CL可有效缓解膝关节疼痛,但是对膝关节积液-滑膜炎或软骨构成没影响。需要有更大样本量的多中心试验来评估这些研究发现的临床意义。该研究的局限性在于样本量不大,持续时间短。

 

原始出处:

 

Zhiqiang Wang, et al., Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. Ann Intern Med. 2020 Dec 1;173(11):861-869. doi: 10.7326/M20-0990.  

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    2021-04-19 lmm397
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    2021-04-19 pcw106
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    2021-04-18 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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