JAHA:代谢综合征和/或糖尿病对轻微缺血性卒中或TIA患者复发性卒中的影响!

2017-06-01 xing.T MedSci原创

由此可见,同时合并METS和DM会增加轻微卒中和短暂性脑缺血发作患者复发性卒中的风险。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在通过氯吡格雷对急性非致残性脑血管事件高危患者的作用试验(CHANCE试验)来明确代谢综合征(METS)和糖尿病(DM)对缺血性卒中或短暂性脑缺血发作患者发生复发性卒中风险的影响。

研究人员共纳入3044例患者。患者被分为4组:既没METS有没DM、只有METS、只有DM或两者均有。研究人员采用中国糖尿病协会(CDS)和国际糖尿病基金会(IDF)的定义来确定METS。该研究的主要研究终点为90天的新发卒中(包括缺血性和出血性卒中)。调整潜在协变量后,多变量Cox回归模型被用来评估METS和DM状态与复发性卒中风险之间的相关性。研究人员使用METS的CDS标准,分别有53.2%、17.2%、19.8%和9.8%的患者被诊断为既没METS有没DM、只有METS、只有DM或两者均有。

随访90天后,有299例新发卒中患者(缺血性卒中患者293例,出血性卒中患者6例)。只有DM患者(16.1% vs. 6.8%,调整后风险比为2.50,95%可信区间为1.89-3.39)和两者均有的患者(17.1% vs. 6.8%,调整后的风险比为2.76,95%可信区间为1.89-3.86)复发性卒中的发生率显著增加。不同的METS或DM状态对复发性卒中风险不受抗血小板治疗相互作用的影响(完全调整的CDS模型相互作用P=0.82)。采用METS(IDF)标准得到了类似的结果。

由此可见,同时合并METS和DM会增加轻微卒中和短暂性脑缺血发作患者复发性卒中的风险。

原始出处:

Weiqi Chen,et al. Recurrent Stroke in Minor Ischemic Stroke or Transient Ischemic Attack With Metabolic Syndrome and/or Diabetes Mellitus.JAHA.2017. http://jaha.ahajournals.org/content/6/6/e005446

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    2017-07-05 马龙
  4. 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  5. 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  6. 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    2017-06-05 往日如昨

    学习了谢谢分享

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=205867, encodeId=13dd20586e7c, content=猝中复发的风险研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Sat Jun 03 07:41:09 CST 2017, time=2017-06-03, status=1, ipAttribution=)]
    2017-06-04 changjiu

    学习了,谢谢分享

    0

  8. 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likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat Jun 03 11:57:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430832, encodeId=009714308322f, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Jun 03 11:57:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), 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    2017-06-03 zhaohui6731
  9. 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  10. 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    2017-06-03 cqykthl

    猝中复发的风险研究

    0

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