Stroke:皮层静脉充盈是大脑中动脉卒中患者临床预后的预测因子

2016-05-25 MedSci MedSci原创

背景:闭塞动脉的下游的静脉血流可影响缺血性卒中患者的预后。研究者旨在应用动态CT血管造影评估皮层静脉充盈(CVF)情况,并且评估其与临床预后的关系。方法:大脑中动脉近端闭塞患者在卒中发病后9小时内行CT平扫及全脑CT灌注/动态CT血管造影。研究者定义不良预后为改良Rankin量表评分≥3。应用泊松回归分析CVF范围和速率和3个月不良预后的相关性。除外年龄,卒中的严重程度、治疗方式、ASPECT评分

背景:闭塞动脉的下游的静脉血流可影响缺血性卒中患者的预后。研究者旨在应用动态CT血管造影评估皮层静脉充盈(CVF)情况,并且评估其与临床预后的关系。

方法:大脑中动脉近端闭塞患者在卒中发病后9小时内行CT平扫及全脑CT灌注/动态CT血管造影。研究者定义不良预后为改良Rankin量表评分≥3。应用泊松回归分析CVF范围和速率与3个月不良预后的相关性。除外年龄,卒中的严重程度、治疗方式、ASPECT评分、脑血流量和侧枝循环外,应用Logistic回归分析最佳CVF(皮层静脉最大充盈区),并计算曲线下面积。

结果:共有88例患者纳入研究,平均年龄67岁。将最佳CVF范围和速度结合分析,研究者观察到最佳CVF良好并且较快的患者,不良预后风险下降,风险比为0.5(95%CI,0.3-0.7)。与没有纳入CVF的风险模型相比,最佳CVF的范围和速率预测价值增加(曲线下面积为0.88;95%CI,0.77-0.98)。

结论:CT血管造影评估中, CVF的范围和速度结合可用于识别大脑中动脉卒中患者3个月临床预后差的高风险患者。

原始出处:

van den Wijngaard IR, Wermer MJ, et al. Cortical Venous Filling on Dynamic Computed Tomographic Angiography: A Novel Predictor of Clinical Outcome in Patients With Acute Middle Cerebral Artery Stroke. Stroke. 2016 Mar.


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    2017-02-05 fusion
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    2016-10-14 ylzr123

    拜读了,受益匪浅,点个赞!

    0

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