韩春雨:《自然》已初步证实实验可重复

2016-09-06 佚名 成都商报

韩春雨介绍,《自然》是第三方,调查是公正、正式的,结果是公开的,《自然》的结果就是,这个实验是可以重复的,但有的能够做出来,有的做不出来。韩春雨承认,NgAgo 这个工具目前确实有很多不完善的地方,影响实验结果的还有一些不确定的因素,做这个实验需要一定的门槛。3 个月前,石家庄河北科技大学的副教授韩春雨在《自然 · 生物技术》杂志刊发重要论文,研究成果表示,NgAgo ( 一种核酸内切酶 )

梅斯医学小编提醒:
这是来自于《成都商报》的文章,并非专业媒体。另外,下面内容仅供参考,而且来自于Nature的采访,并非公开全面的呈述。据有关方面报道,目前具体验证还要进行中,目前还没有明确的结论,需要各方调查进一步深入。我们的愿望是好的,希望中国人也能有原创性的发现,但科学往往是残酷的,需要大量的验证才能证实。也期待有科学的验证结果正式报道出来。

以下是报道:



韩春雨介绍,《自然》是第三方,调查是公正、正式的,结果是公开的,《自然》的结果就是,这个实验是可以重复的,但有的能够做出来,有的做不出来。

韩春雨承认,NgAgo 这个工具目前确实有很多不完善的地方,影响实验结果的还有一些不确定的因素,做这个实验需要一定的门槛。

3 个月前,石家庄河北科技大学的副教授韩春雨在《自然 · 生物技术》杂志刊发重要论文,研究成果表示,NgAgo ( 一种核酸内切酶 ) 可以用来编辑哺乳动物基因组,该成果被誉为 " 诺奖级 "。同时,因其 " 无名校身份 "" 无名气 "" 无职位 " 的 " 三无 " 身份,韩春雨一时成为广受关注的 " 网红 " 科学家。

但随后,一些科研人员质疑韩春雨的实验结果无法重复,而引发 " 造假 " 争议。有媒体 8 月 2 日称,韩春雨将在 1 个月后对此作出回应。上周末,1 个月期限已到,此事再次引发舆论热议,韩春雨也并未接受这些媒体的采访。

昨日,韩春雨接受成都商报记者独家专访,回应质疑称,《自然》杂志已证实实验可重复,但还有不确定因素影响实验结果。

媒体称 1 个月后回应

韩春雨:从未如此表态,但愿意在此期限内给予回应

韩春雨因在《自然 · 生物技术》杂志刊发了题为《NgAgo DNA 单链引导的基因编辑工具》的论文,成为世界关注的科学家。论文内容大致为,以 DNA 来介导 NgAgo 对靶向基因的识别从而进行基因编辑,被认为是基因编辑领域的重大突破。

但随后,一些科学家抱怨说韩春雨的实验结果无法重复。至上月,质疑声音达到顶峰。

有媒体报道,此前曾称已重复实验成功的澳大利亚国立大学医学、生物和环境学院教授盖坦 · 巴尔焦发表博客称,经过多次尝试,仍未重复出韩春雨的结果。博客中,巴尔焦说,他仍未发现任何证据证明 NgAgo 能进行基因组编辑。他甚至得到相矛盾的结果。韩春雨的文章称 NgAgo 在 37 摄氏度以上的实验条件下起作用,但巴尔焦的实验结果却为 50 摄氏度。

与此同时,国际转基因技术协会 ( ISTT ) 在其 Twitter 上推送数位科学家的实名评论,其均无法重复实验结果。

8 月 2 日,有媒体援引该校匿名人士话称,将在 1 个月内给予验证回复。韩春雨告诉成都商报记者,他从未表态 1 个月回复,但既然媒体已经报道了,他仍愿意在此期限内给予回应。

1 个月前,韩春雨曾告诉成都商报记者,科学技术成果不应该是在媒体上吵架。真正的好的技术应该是好用。他认为,自己现在的技术不是那么好用,所以他要继续改进。" 这么短的时间就宣称实验无法复制,在时间上本身就不符合科学,我们必须按照科学的流程和态度去回应、应对质疑 "。

韩春雨认为,澳大利亚专家的质疑从学术来说根本不严谨。而 ISTT 虽然名头很响,但就是个一般的个人申请的组织。

期限已到未见回应

韩春雨:《自然》的调查访谈结果,相当于公开回应

昨日,有媒体提出 1 个月期限已到,针对 NgAgo 的实验却依旧没有任何实验室宣称可以重复,亦未见河北科技大学的后续声明,并表示联系韩春雨本人,其也未做任何回复。

昨日下午,韩春雨接受了成都商报记者独家专访,对此事做出回应。

韩春雨表示,起初,他并不想就此事公开回应。他称,1 个月前,他就此事回应后,一大波媒体蜂拥而至,导致实验室半个月没法运转。他担心再次回应后,又引起关注," 一回应实验室就没法干了,最好的回应还是做出东西来 "。

韩春雨告诉成都商报记者,在上个月社会上有了质疑声音后," 我们不可能放着不管,肯定要做出回应 ",不过对回应的方式做了选择。他们认为在民间回应不合适,他们很快就联系了《自然》的调查员戴卫,用《自然》调查访谈的方式回应。他们认为,《自然》对各种事实有比较全面的调查和报道,这是最好的回应方式。

他介绍,《自然》是第三方,调查是公正、正式的,结果是公开的,《自然》的结果就是,这个实验是可以重复的,但有的能够做出来,有的做不出来。目前,至少已经有 3 名科学家重复了该实验,但 3 人在接受戴卫调查后,不希望被打扰,要求匿名。他认为,《自然》的调查访谈结果已经相当于是公开回应了。

韩春雨承认,NgAgo 这个工具目前确实有很多不完善的地方,影响实验结果的还有一些不确定的因素,做这个实验需要一定的门槛。他的科研组正在寻找更好的方式和检测手段,改进平台,完善实验。

《自然》调查员这样说

成都商报记者检索了解到,今年 8 月 8 日,《自然》正式发文,就近几个月来持续发酵的 " 韩春雨事件 " 进行了详细的报道,作者是该杂志亚洲通讯员戴卫。文章中提到:" 一名不愿透露姓名 ( 不想被卷入公共争论 ) 独立于韩春雨实验室之外的中国研究人员告诉《自然》杂志,他们在好几个细胞系检测了 NgAgo 系统是否有效,而且他们的结果显示 NgAgo 能够在预期的位点诱导遗传突变——这一结果已经通过测序鉴定。"

该人士认为,NgAgo 系统的效率并不比 CRISPR-Cas9 高,可能还要后续调整改进。" 但总的来说 NgAgo 是有效 ( But,in short,it worked ) ",这名科学家最后提到。
两名要求匿名的中国科学家提到,他们有了一些初步的试压结果显示 NgAgo 是有效的,但是仍然需要进一步测序去确认。"

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    2016-09-08 bshuang
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    2016-09-06 KO229256262

    相信,绝对不会作假

    0

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    2016-09-06 waxibin

    the warm congratulation

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1550916, encodeId=dd1b1550916a1, content=<a href='/topic/show?id=662810003e92' target=_blank style='color:#2F92EE;'>#韩春雨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100037, encryptionId=662810003e92, topicName=韩春雨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db0a14143395, createdName=bshuang, createdTime=Thu Sep 08 05:35:00 CST 2016, time=2016-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112713, encodeId=47cf112e1313, content=相信,绝对不会作假, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/17/3872cad7a53dc9dcbd08202fb6313cf4.jpg, createdBy=2cb71609450, createdName=KO229256262, createdTime=Tue Sep 06 22:31:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112556, encodeId=da601125560a, content=the warm congratulation, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87df1446011, createdName=waxibin, createdTime=Tue Sep 06 20:42:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112555, encodeId=ca5411255535, content=恭喜恭喜,希望可以为中国科研人员带来点改变,什么时候能改善一下科研人员的待遇的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erJaiboOUVrGYoHV8Essd0EJvx0DPLDeqP3qkvaGD39DdvMmzT98iaib209rApLicEN84Nu8RefibOh8jA/132, createdBy=75ba1609552, createdName=kingjiang, createdTime=Tue Sep 06 20:30:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112518, encodeId=17ab11251837, content=不简单, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Sep 06 17:16:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112520, encodeId=836611252077, content=权威杂志。, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Sep 06 17:16:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112508, encodeId=64c211250800, content=加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Tue Sep 06 16:53:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112505, encodeId=6dea112505f1, content=可喜可贺!实验可重复性是必须条件, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCYbPBa7AiaIy1pMpp7CF9lHORw4icR9GOrMO6RVNCb1qSUSY9TFBzW5zlrpDia0HKafiarjvcweMaVdg/0, createdBy=f1d61928636, createdName=simayunhe, createdTime=Tue Sep 06 16:49:00 CST 2016, time=2016-09-06, status=1, ipAttribution=)]
    2016-09-06 kingjiang

    恭喜恭喜,希望可以为中国科研人员带来点改变,什么时候能改善一下科研人员的待遇的。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1550916, encodeId=dd1b1550916a1, content=<a href='/topic/show?id=662810003e92' target=_blank style='color:#2F92EE;'>#韩春雨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100037, encryptionId=662810003e92, topicName=韩春雨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db0a14143395, createdName=bshuang, createdTime=Thu Sep 08 05:35:00 CST 2016, time=2016-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112713, encodeId=47cf112e1313, content=相信,绝对不会作假, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/17/3872cad7a53dc9dcbd08202fb6313cf4.jpg, createdBy=2cb71609450, createdName=KO229256262, createdTime=Tue Sep 06 22:31:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112556, encodeId=da601125560a, content=the warm congratulation, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87df1446011, createdName=waxibin, createdTime=Tue Sep 06 20:42:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112555, encodeId=ca5411255535, content=恭喜恭喜,希望可以为中国科研人员带来点改变,什么时候能改善一下科研人员的待遇的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erJaiboOUVrGYoHV8Essd0EJvx0DPLDeqP3qkvaGD39DdvMmzT98iaib209rApLicEN84Nu8RefibOh8jA/132, createdBy=75ba1609552, createdName=kingjiang, createdTime=Tue Sep 06 20:30:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112518, encodeId=17ab11251837, content=不简单, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Sep 06 17:16:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112520, encodeId=836611252077, content=权威杂志。, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Sep 06 17:16:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112508, encodeId=64c211250800, content=加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Tue Sep 06 16:53:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112505, encodeId=6dea112505f1, content=可喜可贺!实验可重复性是必须条件, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCYbPBa7AiaIy1pMpp7CF9lHORw4icR9GOrMO6RVNCb1qSUSY9TFBzW5zlrpDia0HKafiarjvcweMaVdg/0, createdBy=f1d61928636, createdName=simayunhe, createdTime=Tue Sep 06 16:49:00 CST 2016, time=2016-09-06, status=1, ipAttribution=)]
    2016-09-06 jyzxjiangqin

    不简单

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1550916, encodeId=dd1b1550916a1, content=<a href='/topic/show?id=662810003e92' target=_blank style='color:#2F92EE;'>#韩春雨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100037, encryptionId=662810003e92, topicName=韩春雨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db0a14143395, createdName=bshuang, createdTime=Thu Sep 08 05:35:00 CST 2016, time=2016-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112713, encodeId=47cf112e1313, content=相信,绝对不会作假, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/17/3872cad7a53dc9dcbd08202fb6313cf4.jpg, createdBy=2cb71609450, createdName=KO229256262, createdTime=Tue Sep 06 22:31:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112556, encodeId=da601125560a, content=the warm congratulation, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87df1446011, createdName=waxibin, createdTime=Tue Sep 06 20:42:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112555, encodeId=ca5411255535, content=恭喜恭喜,希望可以为中国科研人员带来点改变,什么时候能改善一下科研人员的待遇的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erJaiboOUVrGYoHV8Essd0EJvx0DPLDeqP3qkvaGD39DdvMmzT98iaib209rApLicEN84Nu8RefibOh8jA/132, createdBy=75ba1609552, createdName=kingjiang, createdTime=Tue Sep 06 20:30:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112518, encodeId=17ab11251837, content=不简单, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Sep 06 17:16:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112520, encodeId=836611252077, content=权威杂志。, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Sep 06 17:16:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112508, encodeId=64c211250800, content=加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Tue Sep 06 16:53:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112505, encodeId=6dea112505f1, content=可喜可贺!实验可重复性是必须条件, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCYbPBa7AiaIy1pMpp7CF9lHORw4icR9GOrMO6RVNCb1qSUSY9TFBzW5zlrpDia0HKafiarjvcweMaVdg/0, createdBy=f1d61928636, createdName=simayunhe, createdTime=Tue Sep 06 16:49:00 CST 2016, time=2016-09-06, status=1, ipAttribution=)]
    2016-09-06 jyzxjiangqin

    权威杂志。

    0

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    2016-09-06 童小孩

    加油

    0

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    2016-09-06 simayunhe

    可喜可贺!实验可重复性是必须条件

    0

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