Circulation:产前超声检查对主动脉缩窄的危险因素评估

2016-12-30 xing.T MedSci原创

采用多指标预测模型时,主动脉缩窄的检出率可以提高。为开发这些胎儿风险评估的客观模型进一步的大型共享相同的影像协议的多中心研究是必要的。

主动脉缩窄的产前诊断仍然具有挑战性,并且受高假阳性诊断率的影响。近日,心血管领域权威杂志Circulation上发表了一篇研究文章,旨在确定关联强度以及定量主动脉缩窄产前诊断中不同超声征象的诊断准确性。

研究人员通过检索MEDLINEEMBASECINAHLCochrane数据库,并采用随机效应和HSROC荟萃分析模型对数据进行分析。

研究人员从794篇文献中选取了12篇文献(922例胎儿有主动脉缩窄风险)。相比没有主动脉缩窄的胎儿,存在主动脉缩窄的胎儿平均二尖瓣直径Z值较低(P0.001)和平均三尖瓣直径Z值较高(P=0.01),另外,主动脉缩窄的胎儿平均主动脉瓣直径Z值也较低(P0.001),但是升主动脉直径,无论是用Z值或毫米来表示,在两组间也较为相似(分别P=0.070.47)。平均主动脉峡部直径Z值无论在矢状面(P=0.02)还是三血管气管切面(P0.001)在主动脉缩窄的胎儿中均较低。相反,在主动脉缩窄的胎儿中平均肺动脉内径Z值、右/左心室和肺动脉/升主动脉直径比值均明显增高(分别有P0.001P = 0.02P = 0.02),而主动脉峡部/动脉导管直径比值较低(P0.001)。在主动脉缩窄的胎儿中缩窄结构和主动脉弓发育不良比对照组更普遍(比值比为26.095%可信区间为4.42-153P0.001;比值比为38.295%可信区间为3.01-486P=0.005),而永存左上腔静脉(P=0.85)、室间隔缺损(P=0.12)和二叶式主动脉瓣(P=0.14)并没有增加这一异常的风险。整合了检测主动脉缩窄不同的超声征象的多参数诊断模型可以增加主动脉缩窄的检出率。

采用多指标预测模型时,主动脉缩窄的检出率可以提高。为开发这些胎儿风险评估的客观模型进一步的大型共享相同的影像协议的多中心研究是必要的。

原始出处:

Alessandra Familiari,et al. Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis. Circulation.December 29, 2016.

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    2017-01-01 李东泽

    很好,不错,以后会多学习

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=2024537, encodeId=1232202453e10, content=<a href='/topic/show?id=52322443994' target=_blank style='color:#2F92EE;'>#产前超声检查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24439, encryptionId=52322443994, topicName=产前超声检查)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Thu Dec 07 06:23:00 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973166, encodeId=5db419e31669e, content=<a href='/topic/show?id=550a2443846' target=_blank style='color:#2F92EE;'>#产前超声#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24438, encryptionId=550a2443846, topicName=产前超声)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=232a2500033, createdName=1249859em38(暂无昵称), createdTime=Sun May 07 15:23:00 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689952, encodeId=abf8168995269, content=<a href='/topic/show?id=4dea232255a' target=_blank style='color:#2F92EE;'>#主动脉缩窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23225, encryptionId=4dea232255a, topicName=主动脉缩窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=733c28929617, createdName=12498e8em81暂无昵称, createdTime=Wed Jan 25 23:23:00 CST 2017, time=2017-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167286, encodeId=e49616e28678, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Jan 01 19:05:26 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1284288, encodeId=8f041284288d5, content=<a href='/topic/show?id=d27a9280461' target=_blank style='color:#2F92EE;'>#超声检查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92804, encryptionId=d27a9280461, topicName=超声检查)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=649f191, createdName=zzc2211, createdTime=Sun Jan 01 13:23:00 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415107, encodeId=afa0141510ecc, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Sun Jan 01 13:23:00 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502494, encodeId=b9371502494d3, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Sun Jan 01 13:23:00 CST 2017, time=2017-01-01, status=1, ipAttribution=)]
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    2017-01-01 qilu_qi