Diabetes Obes Metab:Apelin治疗可改善超重男性的胰岛素敏感性!

2017-07-07 xing.T MedSci原创

由此可见,该研究首次正式了Apelin在人类中可如许多啮齿动物研究中一样具有增加胰岛素敏感性的作用,该试验证实了Apelin/APJ通路应被作为控制2型糖尿病患者胰岛素抵抗设计替代治疗策略的新靶标。

Apelin是最近确定的脂肪因子,已知可以改善小鼠模型中的葡萄糖耐量和胰岛素敏感性。近日,代谢内分泌疾病领域权威杂志Diabetes Obesity & Metabolism上发表了一篇研究文章,这项研究旨在证明采用Apelin治疗也可以增强人类的胰岛素敏感性。

研究人员将健康超重男性招募入这项随机、双盲、安慰剂对照的交叉研究中,旨在确定两种剂量(pyr1)-Apelin-13的疗效和耐受性。在评估了安全性数据后,第一组受试者接受了9nmol/kg(n=8)(pyr1)-Apelin-13治疗,第二组受试者接受了30nmol/kg(n=8)(pyr1)-Apelin-13治疗。每个志愿者接受了两次高胰岛素正常血糖钳夹,其中测量的葡萄糖输注速率(GIR)基础水平从第90到第120分钟(第1水平)。Apelin或安慰剂连续静脉给药2小时,最后从第210到第240分钟(第2水平)评估GIR。该研究的主要评估终点为第2和第1水平之间的GIR差异(ΔGIR)。

研究人员发现Apelin低剂量组ΔGIR轻微升高(+0.65±0.71 mg/kg/min,P=0.055),而最高剂量组的胰岛素敏感性则显著改善(+0.82±0.71mg/kg/min,P=0.033)。心血管监测和安全性报告没有显示采用Apelin治疗有任何副作用。

由此可见,该研究首次正式了Apelin在人类中可如许多啮齿动物研究中一样具有增加胰岛素敏感性的作用,该试验证实了Apelin/APJ通路应被作为控制2型糖尿病患者胰岛素抵抗设计替代治疗策略的新靶标。

原始出处:

Pierre Gourdy,et al. Apelin administration improves insulin sensitivity in overweight men during an hyperinsulinemic euglycemic clamp.Diabetes Obesity & Metabolism.2017. http://onlinelibrary.wiley.com/doi/10.1111/dom.13055/full

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    2018-01-07 一闲
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content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Thu Feb 08 11:24:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887688, encodeId=40de188e68844, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Jan 02 05:24:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220321, encodeId=cea7220321c7, content=谢谢,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Jul 09 13:32:57 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2018-06-06 baoya
  5. [GetPortalCommentsPageByObjectIdResponse(id=1760111, encodeId=70e01e601110c, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Thu Feb 01 03:24:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896106, encodeId=2d5f189610650, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, 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time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220321, encodeId=cea7220321c7, content=谢谢,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Jul 09 13:32:57 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1760111, encodeId=70e01e601110c, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Thu Feb 01 03:24:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896106, encodeId=2d5f189610650, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, 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content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Thu Feb 08 11:24:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887688, encodeId=40de188e68844, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Jan 02 05:24:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220321, encodeId=cea7220321c7, content=谢谢,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Jul 09 13:32:57 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-12-13 feather89
  7. 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time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220321, encodeId=cea7220321c7, content=谢谢,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Jul 09 13:32:57 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2018-02-20 qindq
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    2018-01-02 guojianrong
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    2017-07-09 changjiu

    谢谢,学习了

    0

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