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DES较BMS改善CABG手术中静脉移植物损伤转归

2011-04-09 MedSci原创 MedSci原创

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MedSci提示：如果比较DES与BMS对桡动脉移植物的转归，又将是一篇重要的文章。相信很快就会有类似文章出现。因为目前大量研究表明，就CABG移植物而言，桡动脉较隐静脉具有较大优势。见报道：CABG：桡动脉优于隐静脉 作者：王晓东译 来源：医学论坛网 　　在迄今最大规模的对药物洗脱支架（DES）与裸金属支架（BMS）对隐静脉移植物损伤的影响进行比较的随机、多中心临床研究中，研究者发现DES可

MedSci提示：如果比较DES与BMS对桡动脉移植物的转归，又将是一篇重要的文章。相信很快就会有类似文章出现。因为目前大量研究表明，就CABG移植物而言，桡动脉较隐静脉具有较大优势。见报道：CABG：桡动脉优于隐静脉

作者：王晓东译 来源：医学论坛网

　　在迄今最大规模的对药物洗脱支架（DES）与裸金属支架（BMS）对隐静脉移植物损伤的影响进行比较的随机、多中心临床研究中，研究者发现DES可使患者由死亡、心脏病发作与再次血运重建组成的复合终点发生率降低。该研究日前于美国心脏病学会2011年科学年会（ACC.11）上报告。

　　在该研究中，来自德国的研究者入选610例既往接受过CABG手术的患者，所有患者均发生至少一处移植损伤，并随机接受DES（n = 303）或BMS （n = 307）修补治疗。研究主要终点为随访1年主要不良心脏事件，次要终点为1年期个体死亡率、心脏事件、ARC（学术研究委员会）定义的支架血栓，以及损伤相关的血运重建。

　　研究者发现，DES队列主要心脏不良事件发生率较BMS组低35%，DES组16.5%的患者发生主要终点事件，BMS组为22.1%（HR= 0.65）。DES组这一降低结果主要缘于损伤相关的血运重建比例显著低于BMS组（7.2%对12.9%，P= 0.020）。两组次要终点事件无明显差别。

　　隐静脉移植（SVG）在CABG手术中经常采用，移植物在局部可导致动脉粥样硬化性病变，许多患者术后出现血管管腔狭窄、闭塞。

　　新闻链接：

　　Drug-Eluting Stents Improve Outcomes Compared to Bare-Metal Stents in Saphenous Vein Graft Lesions

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    2011-05-11 医者仁心

    #植物#

    0

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    2011-07-26 fusion

    #静脉#

    0

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    2011-04-11 canlab

    #BMS#

    0

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    2011-04-11 智者为医08

    #损伤#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1745140, encodeId=c1981e451408f, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed May 11 03:40:00 CST 2011, time=2011-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697120, encodeId=fbb8169e12087, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Tue Jul 26 00:40:00 CST 2011, time=2011-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378632, encodeId=f2de13e8632c6, content=<a href='/topic/show?id=f238358866' target=_blank style='color:#2F92EE;'>#BMS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3588, encryptionId=f238358866, topicName=BMS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512d422, createdName=canlab, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396659, encodeId=fa46139665998, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558474, encodeId=ba0715584e474, content=<a href='/topic/show?id=b68a586365' target=_blank style='color:#2F92EE;'>#DES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5863, encryptionId=b68a586365, topicName=DES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=432c14994935, createdName=fusion, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564483, encodeId=68bc156448399, content=<a href='/topic/show?id=b68a586365' target=_blank style='color:#2F92EE;'>#DES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5863, encryptionId=b68a586365, topicName=DES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=432c14994935, createdName=fusion, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620671, encodeId=1fb316206e18a, content=<a href='/topic/show?id=c0c9e520310' target=_blank style='color:#2F92EE;'>#移植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75203, encryptionId=c0c9e520310, topicName=移植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=153620156575, createdName=10518100zz, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=)]
    2011-04-11 fusion

    #DES#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1745140, encodeId=c1981e451408f, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed May 11 03:40:00 CST 2011, time=2011-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697120, encodeId=fbb8169e12087, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Tue Jul 26 00:40:00 CST 2011, time=2011-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378632, encodeId=f2de13e8632c6, content=<a href='/topic/show?id=f238358866' target=_blank style='color:#2F92EE;'>#BMS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3588, encryptionId=f238358866, topicName=BMS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512d422, createdName=canlab, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396659, encodeId=fa46139665998, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558474, encodeId=ba0715584e474, content=<a href='/topic/show?id=b68a586365' target=_blank style='color:#2F92EE;'>#DES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5863, encryptionId=b68a586365, topicName=DES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=432c14994935, createdName=fusion, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564483, encodeId=68bc156448399, content=<a href='/topic/show?id=b68a586365' target=_blank style='color:#2F92EE;'>#DES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5863, encryptionId=b68a586365, topicName=DES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=432c14994935, createdName=fusion, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620671, encodeId=1fb316206e18a, content=<a href='/topic/show?id=c0c9e520310' target=_blank style='color:#2F92EE;'>#移植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75203, encryptionId=c0c9e520310, topicName=移植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=153620156575, createdName=10518100zz, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=)]
    2011-04-11 fusion

    #DES#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1745140, encodeId=c1981e451408f, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed May 11 03:40:00 CST 2011, time=2011-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697120, encodeId=fbb8169e12087, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Tue Jul 26 00:40:00 CST 2011, time=2011-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378632, encodeId=f2de13e8632c6, content=<a href='/topic/show?id=f238358866' target=_blank style='color:#2F92EE;'>#BMS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3588, encryptionId=f238358866, topicName=BMS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512d422, createdName=canlab, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396659, encodeId=fa46139665998, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558474, encodeId=ba0715584e474, content=<a href='/topic/show?id=b68a586365' target=_blank style='color:#2F92EE;'>#DES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5863, encryptionId=b68a586365, topicName=DES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=432c14994935, createdName=fusion, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564483, encodeId=68bc156448399, content=<a href='/topic/show?id=b68a586365' target=_blank style='color:#2F92EE;'>#DES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5863, encryptionId=b68a586365, topicName=DES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=432c14994935, createdName=fusion, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620671, encodeId=1fb316206e18a, content=<a href='/topic/show?id=c0c9e520310' target=_blank style='color:#2F92EE;'>#移植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75203, encryptionId=c0c9e520310, topicName=移植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=153620156575, createdName=10518100zz, createdTime=Mon Apr 11 00:40:00 CST 2011, time=2011-04-11, status=1, ipAttribution=)]
    2011-04-11 10518100zz

    #移植物#

    0