JAMA:使用非甾体抗炎药降低结直肠癌患病风险

2015-03-31 赵洲译 MedSci原创

相当多的证据表明使用阿司匹林和其他的非甾体抗炎药物与罹患结肠直肠癌的更低的风险有关。但是,在这一联系背后所隐藏的机制尚未为人所知。常规使用阿司匹林或者其他非甾体现在并未被推荐用来预防癌症,这是由于对这一方案的风险尚不确定。因此,了解基因包机无和非甾体抗炎药的使用之间的内在关系(基因×环境相互作用)可以帮助确证使用非甾体抗炎药是否可以降低罹患结直肠癌的风险。 在此次病例对照研究中,研究人员使用

相当多的证据表明使用阿司匹林和其他的非甾体抗炎药物与罹患结肠直肠癌的更低的风险有关。但是,在这一联系背后所隐藏的机制尚未为人所知。常规使用阿司匹林或者其他非甾体现在并未被推荐用来预防癌症,这是由于对这一方案的风险尚不确定。因此,了解基因包机无和非甾体抗炎药的使用之间的内在关系(基因×环境相互作用)可以帮助确证使用非甾体抗炎药是否可以降低罹患结直肠癌的风险。

在此次病例对照研究中,研究人员使用了美国、加拿大、澳大利亚和德国的5组病例对照和5组群体研究的数据,这些研究都是在19762003年之间开始的。数据包括了8634例结直肠癌病例和8553例相匹配的对照组。参与者全都是欧洲人的后裔。与不规律使用非甾体抗炎药相比,规律性使用非甾体抗炎药和更低风险患结直肠癌有关。在传统逻辑回归分析中,靠近MGST1基因位于染色体12p12.3的单核苷酸多态性表现出与非甾体抗炎药显著的相互作用。规律用药与具rs16973225-AA基因型的人更低风险患结直肠癌有关,但与ACCC基因型无关。

在此次基因×环境相互作用的全基因组的研究中,使用阿司匹林和/或其他非甾体抗炎药的确与更低风险患结直肠癌有关。这一关系有所区别,因为2个染色体上的遗传变异。对于其他人群使用非甾体抗炎药是否可以降低结直肠癌患病风险的研究或许能帮助靶向预防结直肠癌。

原始出处:

Nan H, Hutter CM, Lin Y, et al. Association of Aspirin and NSAID Use With Risk of Colorectal Cancer According to Genetic Variants. JAMA2015;

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    2021-02-19 dearluodi

    学习了,谢谢

    0

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    2021-02-19 dearluodi

    学习了,谢谢

    0

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    2021-02-19 dearluodi

    学习了,谢谢

    0

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    2021-02-19 dearluodi

    学习了,谢谢

    0

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    2016-03-18 1ddc978cm67(暂无匿称)

    谢谢分享。

    0

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    2016-03-16 任然

    好东西呀

    0

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    2016-02-11 lietome1

    收藏

    0

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    2016-01-27 文医生

    有待考证

    0

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    2016-01-26 doctording1

    是一篇不错的文章

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=925581, encodeId=0209925581d5, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Fri Feb 19 22:30:05 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925580, encodeId=411392558089, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Fri Feb 19 22:29:49 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925579, encodeId=936b9255e991, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Fri Feb 19 22:29:41 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925578, encodeId=3cd49255e807, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Fri Feb 19 22:29:37 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71506, encodeId=4ebce150687, content=谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73801651090, createdName=1ddc978cm67(暂无匿称), createdTime=Fri Mar 18 12:11:00 CST 2016, time=2016-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=69584, encodeId=0e5369584f0, content=好东西呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9a01693879, createdName=任然, createdTime=Wed Mar 16 12:23:00 CST 2016, time=2016-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63936, encodeId=efd76393648, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Thu Feb 11 09:40:00 CST 2016, time=2016-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60880, encodeId=489e60880e1, content=有待考证, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Jan 27 14:43:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59941, encodeId=658f5994128, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:14:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59939, encodeId=9496599392a, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:14:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-01-26 doctording1

    这篇文章有一定深度

    0

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