JAMA SURGERY:肝切除术后残余肝组织缺血与肝细胞癌早期复发及不良预后有关

2017-05-06 MedSci MedSci原创

肝切除术后残余肝可能会出现血供不足,尤其是进行非解剖性切除以及存在血管损伤的残余肝,血供不足的情况更为严重。JAMA SURGERY近期报道了一篇文章,评估残余肝缺血(RLI)对于肝细胞癌患者肝切除术后长期生存及死亡率的影响。

肝切除术后残余肝可能会出现血供不足,尤其是进行非解剖性切除以及存在血管损伤的残余肝,血供不足的情况更为严重。JAMA SURGERY近期报道了一篇文章,评估残余肝缺血(RLI)对于肝细胞癌患者肝切除术后长期生存及死亡率的影响。

文章回顾性分析了328例接受肝切除的肝细胞癌患者,根据术后CT对残余肝组织缺血程度进行分级。静脉期出现造影增强减弱或缺失则认为存在残余肝组织缺血。残余肝缺血分为轻度缺血(无缺血或边缘缺血)及严重缺血(部分缺血、节段性缺血或坏死)。在328例患者中,98例患者出现严重缺血,其中63例部分缺血,16例节段性缺血,19例出现坏死。这些严重缺血的患者术后并发症及住院时间均多于轻度缺血患者。术前接受过肝动脉栓塞术、肝门阻断以及较长的手术时间是严重残余肝缺血的独立风险因素。与轻度残余肝缺血的患者相比,残余肝严重缺血的患者肝切除术后6或12个月的早起复发率更高。严重残余肝缺血是总生存及无病生存的独立危险因素。

文章最后认为,肝切除术前管理及技术改进对降低残余肝缺血风险及改善肝细胞癌患者生存至关重要。

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    2017-10-27 songbq
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  5. 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href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Thu Oct 12 19:21:00 CST 2017, time=2017-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197315, encodeId=289919e315ad, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Sat May 13 05:35:17 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196302, encodeId=1b43196302b0, content=厉害厉害学习理论, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Wed May 10 17:43:27 CST 2017, time=2017-05-10, status=1, ipAttribution=)]
    2017-05-29 chg121
  6. 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  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196302, encodeId=1b43196302b0, content=厉害厉害学习理论, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Wed May 10 17:43:27 CST 2017, time=2017-05-10, status=1, ipAttribution=)]
    2017-09-28 xjy02
  8. 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  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196302, encodeId=1b43196302b0, content=厉害厉害学习理论, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Wed May 10 17:43:27 CST 2017, time=2017-05-10, status=1, ipAttribution=)]
    2017-05-13 lou.minghong

    学习

    0

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    2017-05-10 尹玉伟

    厉害厉害学习理论

    0

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肝细胞癌在男性中更为多发切侵袭能力更强,但是这一性别现象的机制仍是未知的。慢性炎症肝细胞癌发生的主要病因。

Plos One:获得性免疫治疗对肝细胞癌患者是否有益?

获得性免疫治疗(AIT)对接受治愈性治疗的肝细胞癌(HCC)患者的作用尚未得到充分说明。近期,一项发表在Plos One上的荟萃分析旨在更新目前有关接受治愈疗法的HCC患者的AIT疗效和安全性的相关证据。此项研究于2017年1月搜索PubMed、EMBASE、Scopus和Cochrane图书馆数据库。在有或无辅助AIT的患者之间比较死亡率和肿瘤复发情况。荟萃分析使用Review Manager

Hepatology:乙醛脱氢酶2通过调节AMPK通路抑制肝细胞癌进展

背景:对于肝细胞癌患者而言,迫切需要可预测预后且可作为治疗靶点的潜在生物标记物。方法:为满足这一需求,我们通过筛查来识别在转录组学和蛋白组学水平同肝细胞癌发生及进展相关的功能基因。结果:乙醛脱氢酶-2(ALDH2)被作为兴趣基因进行进一步研究。同正常组织相比,肿瘤组织的ALDH2的mRNA和蛋白水平显着降低,在迁徙能力更强的组织中其水平更低。临床相关性研究提示ALDH2同存活率及多发迁徙相关的临床

Gastroenterol:一种驱虫药有望高效地治疗肝细胞癌

作为一种与肝病和肝硬化相关联的癌症,肝细胞癌(HCC)经常在晚期时才表现出症状。在全世界,它是癌症死亡的第二大原因,但是迄今为止,它并没有一种有效的疗法。 美国加州大学旧金山分校计算健康科学研究所主任Atul Butte博士说,正如没有治疗方法的其他疾病那样,需要理解和治疗这种癌

Gur:肝细胞癌进展的新机制!

染色体不稳定(CIN)是基因组不稳定的最常见形式,其通过增强肿瘤异质性、耐药性和免疫逃逸促进肝细胞癌(HCC)的进展。CIN本身是DNA损伤的重要因素,维持结构染色体异常,但其潜在的机制尚未可知。近期,一项发表在杂志GUT上的研究使用二乙基亚硝胺诱导的HCC动物模型评估了DNA损伤反应蛋白检查点激酶2(Chk2)的表达。Chk2同时也在两个人类肝癌样本队列中确定。为了评估Chk2的功能作用,通过使

J Gastroenterol:乐伐替尼晚期肝细胞癌2期临床研究

背景:乐伐替尼是一种口服的血管内皮生长因子受体1-3、成纤维细胞生长因子受体1-4、血小板源性生长因子受体α、RET及KIT抑制剂。该2期、单组、非盲、多中心研究旨在评估乐伐替尼在晚期肝细胞癌中的作用。方法:病理或临床确诊的晚期肝细胞癌患者,不适合外科手术切除或局部治疗者,接受每天12mg的乐伐替尼治疗,28天为一周期。主要观察终点为肿瘤进展时间/校正的实体肿瘤疗效评价标准V1.1。次要终点包括客