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J CLIN PSYCHIAT：睡眠剥夺有利于对抗抑郁症

2017-09-20 海北 MedSci原创

抑郁睡眠剥夺
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最近，来自宾夕法尼亚大学医学院的研究人员进行了睡眠剥夺的抗抑郁作用的定量荟萃分析，以补充针对应答率的定性评价。研究人员通过PubMed和PsycINFO数据库搜索了1974年至2016年的英文研究内容，实验的关键词是睡眠剥夺和抑郁症。

最近，来自宾夕法尼亚大学医学院的研究人员进行了睡眠剥夺的抗抑郁作用的定量荟萃分析，以补充针对应答率的定性评价。研究人员通过PubMed和PsycINFO数据库搜索了1974年至2016年的英文研究内容，实验的关键词是睡眠剥夺和抑郁症。

最后，共有66项独立研究符合纳入标准。这些研究进行实验性睡眠剥夺，报告了对睡眠剥夺作出反应的样本的百分比，提供了抗抑郁反应的先验定义，并且没有将睡眠剥夺与其他疗法结合（例如，时间治疗，重复经颅磁刺激）。

研究人员在这些独立研究中提取的数据包括应答者的百分比，样本的类型（例如双极性，单极性），睡眠剥夺的类型（例如，总体，部分），人口统计学，药物使用，使用的结果测量类型和反应的定义（例如，抑郁评分降低30％）。数据采用比例荟萃分析和泊松混合效应回归模型进行分析。

结果显示，使用随机对照组的研究中，睡眠剥夺的总体反应率为45％，而没有随机对照组的研究中，总体反应率为50％。睡眠剥夺的反应没有受到睡眠剥夺的类型，临床样本的性质，用药状态，使用的反应定义，或样本的年龄和性别的显着影响。

该研究支持睡眠剥夺的显着影响，并表明今后需要更多的在神经生物学作用机制以及抑郁症睡眠剥夺治疗反应调节剂的层面研究睡眠剥夺的抗抑郁反应。


原始出处：

Elaine M. Boland et al. Meta-Analysis of the Antidepressant Effects of Acute Sleep Deprivation. The Journal of Clinical Psychiatry, 2017; DOI: 10.4088/JCP.16r11332


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    2017-09-21 wushaoling

    #抗抑郁#

    0

  2. 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    2017-09-21 qjddjq

    #睡眠剥夺#

    0

  3. 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    2017-09-21 戒馋，懒，贪

    谢谢分享

    0

  4. 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    2017-09-20 大叔默默路过

    应该说.很多抑郁症患者.因为胡思乱想.本身睡眠都不是太好.可能睡眠戒断.可以造成思维更加混沌.反而不能想东想西了

    0

  5. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Wed Sep 20 07:51:07 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-20 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

  6. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Wed Sep 20 07:51:07 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-20 sunfeifeiyang

    不睡觉可以抗抑郁?

    0

  7. 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likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Wed Sep 20 08:29:03 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245923, encodeId=25cc245923e7, content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ae02063908, createdName=152****8376, createdTime=Wed Sep 20 07:53:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245918, encodeId=f7d2245918f3, content=喜欢的话小虎还乡好哒好哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Wed Sep 20 07:51:07 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-20 尹玉伟

    厉害厉害--学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1492189, encodeId=a21f14921896a, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Thu Sep 21 22:12:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586695, encodeId=84d8158669502, content=<a href='/topic/show?id=002ee2979c7' target=_blank style='color:#2F92EE;'>#睡眠剥夺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72979, encryptionId=002ee2979c7, topicName=睡眠剥夺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=116c17370512, createdName=qjddjq, createdTime=Thu Sep 21 22:12:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246324, encodeId=19d1246324d8, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Thu Sep 21 13:11:58 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246032, encodeId=9b15246032c6, content=应该说.很多抑郁症患者.因为胡思乱想.本身睡眠都不是太好.可能睡眠戒断.可以造成思维更加混沌.反而不能想东想西了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210427/b594a756d77e4171b5313e531ef89b43/31c000a8a97d4872b698c80fb8a33369.jpg, createdBy=624b2152505, createdName=大叔默默路过, createdTime=Wed Sep 20 16:56:58 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246027, encodeId=5df724602edc, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Sep 20 16:28:06 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245950, encodeId=018a245950f8, content=不睡觉可以抗抑郁?, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Sep 20 09:22:15 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245939, encodeId=6b3b24593981, content=厉害厉害--学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Wed Sep 20 09:11:50 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245929, encodeId=96c024592959, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Wed Sep 20 08:29:03 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245923, encodeId=25cc245923e7, content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ae02063908, createdName=152****8376, createdTime=Wed Sep 20 07:53:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245918, encodeId=f7d2245918f3, content=喜欢的话小虎还乡好哒好哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Wed Sep 20 07:51:07 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-20 Drhzm308

    谢谢.学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1492189, encodeId=a21f14921896a, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Thu Sep 21 22:12:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586695, encodeId=84d8158669502, content=<a href='/topic/show?id=002ee2979c7' target=_blank style='color:#2F92EE;'>#睡眠剥夺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72979, encryptionId=002ee2979c7, topicName=睡眠剥夺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=116c17370512, createdName=qjddjq, createdTime=Thu Sep 21 22:12:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246324, encodeId=19d1246324d8, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Thu Sep 21 13:11:58 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246032, encodeId=9b15246032c6, content=应该说.很多抑郁症患者.因为胡思乱想.本身睡眠都不是太好.可能睡眠戒断.可以造成思维更加混沌.反而不能想东想西了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210427/b594a756d77e4171b5313e531ef89b43/31c000a8a97d4872b698c80fb8a33369.jpg, createdBy=624b2152505, createdName=大叔默默路过, createdTime=Wed Sep 20 16:56:58 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246027, encodeId=5df724602edc, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Sep 20 16:28:06 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245950, encodeId=018a245950f8, content=不睡觉可以抗抑郁?, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Sep 20 09:22:15 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245939, encodeId=6b3b24593981, content=厉害厉害--学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Wed Sep 20 09:11:50 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245929, encodeId=96c024592959, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Wed Sep 20 08:29:03 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245923, encodeId=25cc245923e7, content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ae02063908, createdName=152****8376, createdTime=Wed Sep 20 07:53:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245918, encodeId=f7d2245918f3, content=喜欢的话小虎还乡好哒好哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Wed Sep 20 07:51:07 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-20 152****8376

    谢谢分享受益匪浅

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1492189, encodeId=a21f14921896a, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Thu Sep 21 22:12:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586695, encodeId=84d8158669502, content=<a href='/topic/show?id=002ee2979c7' target=_blank style='color:#2F92EE;'>#睡眠剥夺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72979, encryptionId=002ee2979c7, topicName=睡眠剥夺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=116c17370512, createdName=qjddjq, createdTime=Thu Sep 21 22:12:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246324, encodeId=19d1246324d8, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Thu Sep 21 13:11:58 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246032, encodeId=9b15246032c6, content=应该说.很多抑郁症患者.因为胡思乱想.本身睡眠都不是太好.可能睡眠戒断.可以造成思维更加混沌.反而不能想东想西了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210427/b594a756d77e4171b5313e531ef89b43/31c000a8a97d4872b698c80fb8a33369.jpg, createdBy=624b2152505, createdName=大叔默默路过, createdTime=Wed Sep 20 16:56:58 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246027, encodeId=5df724602edc, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Sep 20 16:28:06 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245950, encodeId=018a245950f8, content=不睡觉可以抗抑郁?, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Sep 20 09:22:15 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245939, encodeId=6b3b24593981, content=厉害厉害--学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Wed Sep 20 09:11:50 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245929, encodeId=96c024592959, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Wed Sep 20 08:29:03 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245923, encodeId=25cc245923e7, content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ae02063908, createdName=152****8376, createdTime=Wed Sep 20 07:53:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245918, encodeId=f7d2245918f3, content=喜欢的话小虎还乡好哒好哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Wed Sep 20 07:51:07 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-20 陈方郑

    喜欢的话小虎还乡好哒好哒

    0

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随着现代社会的高速发展，抑郁症发病率逐年提高，抑郁症已成为全球性社会问题。现有药物的副作用、起效慢、个体差异等问题依然困扰着抑郁疾病的临床治疗。双孔钾离子通道是近年发现的一类新型钾通道超家族，其中TREK1双孔钾离子通道成为抗抑郁治疗、镇痛和治疗脑缺血的重要潜在新靶点，筛选和发现TREK1钾通道的高效抑制剂是抗抑郁症药物研发的重要方向之一。通过在调控机制和调控位点等基础研究上取得突破，上海药物所李

SCI REP：血清同型半胱氨酸水平与青少年焦虑和抑郁之间的关系！

该研究的结果表明，在年龄较大的男孩中，抑郁和焦虑的增加与血清同型半胱氨酸水平呈正相关。该研究结果为研究人群焦虑和抑郁的生物学方面提供了必要的数据。

预防自杀：安定医院罗炯：抑郁“黑狗”偷走了谁的生命？

英国前首相丘吉尔曾这样描述抑郁症：“心中的抑郁就像只黑狗，一有机会就咬住我不放。”从此，“黑狗”成为了英语中抑郁的代名词。很不幸的是，这条“黑狗”也咬住了我国抑郁症患者的生命。

抑郁症产妇顺产异常焦躁 医生跪地全程紧握其手陪产

为了安抚抑郁症产妇情绪，医生跪地全程握着产妇的手陪产两个多小时，终于帮助产妇成功顺产一名健康男婴。