BMC Cancer:神药阿司匹林能降低肺癌相关死亡风险吗?

2015-12-22 MedSci译 MedSci原创

临床证据表明阿司匹林可以抑制肺癌进展,研究者对肺癌患者进行了一项大的队列研究,调查了使用低剂量阿司匹林是否能减少肺癌特异性死亡率风险。该研究纳入了1998-2009年间诊断为肺癌的14,735名患者,采集相关信息以及肺癌相关死亡情况。使用Cox风险比例模型计算肺癌诊断前后低剂量阿司匹林的使用和肺癌特异性死亡率间联系。对3,635名肺癌患者数据的分析显示,诊断肺癌后使用低剂量阿司匹林不会降低肺癌相关

临床证据表明阿司匹林可以抑制肺癌进展,研究者对肺癌患者进行了一项大的队列研究,调查了使用低剂量阿司匹林是否能减少肺癌特异性死亡率风险。

该研究纳入了1998-2009年间诊断为肺癌的14,735名患者,采集相关信息以及肺癌相关死亡情况。使用Cox风险比例模型计算肺癌诊断前后低剂量阿司匹林的使用和肺癌特异性死亡率间联系。

对3,635名肺癌患者数据的分析显示,诊断肺癌后使用低剂量阿司匹林不会降低肺癌相关死亡率(aHR = 0.96, 95 % CI: 0.85, 1.09),同样诊断肺癌前使用低剂量阿司匹林也不能降低肺癌相关死亡风险 (aHR = 1.00, 95 % CI: 0.95, 1.05)。

研究结果表明,该项基于人群的大型肺癌队列研究数据,并不支持低剂量阿司匹林降低肺癌相关死亡风险。

原始出处:


Mc Menamin ÚC, Cardwell CR,et al.Low-dose aspirin and survival from lung cancer: a population-based cohort study.BMC Cancer. 2015 Nov 17;15(1):911.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1974653, encodeId=9ee519e4653fd, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sun Apr 10 09:59:00 CST 2016, time=2016-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51808, encodeId=ac1f51808d6, content=好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Mon Jan 04 18:20:00 CST 2016, time=2016-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48744, encodeId=d17448e449d, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Sun Dec 27 07:33:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47842, encodeId=e2fb4e842a8, content=对预防癌症有一定的作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Sat Dec 26 01:08:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255544, encodeId=7ffb1255544b0, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Thu Dec 24 13:59:00 CST 2015, time=2015-12-24, status=1, ipAttribution=)]
    2016-01-04 xyfg98

    好的

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1974653, encodeId=9ee519e4653fd, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sun Apr 10 09:59:00 CST 2016, time=2016-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51808, encodeId=ac1f51808d6, content=好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Mon Jan 04 18:20:00 CST 2016, time=2016-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48744, encodeId=d17448e449d, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Sun Dec 27 07:33:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47842, encodeId=e2fb4e842a8, content=对预防癌症有一定的作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Sat Dec 26 01:08:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255544, encodeId=7ffb1255544b0, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Thu Dec 24 13:59:00 CST 2015, time=2015-12-24, status=1, ipAttribution=)]
    2015-12-27 wzf990214

    0

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    2015-12-26 jetleo

    对预防癌症有一定的作用。

    0

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