Nature Genetics:偏头痛遗传根源

2013-06-28 腾讯科学 腾讯科学

英美等国研究人员的一项新研究首次确认了5个与偏头痛有关的基因区域,这将有助于科学家进一步了解偏头痛的病因,进而找到更好的治疗方法。 由英国、美国、澳大利亚等国研究人员组成的研究小组在《自然遗传学》杂志上发表论文称,他们完成了一项有史以来最大规模的偏头痛研究项目,通过对近12万个样本进行对比研究,最终确认了12个与偏头痛易感性有关的基因区域,其中5个基因区域为最新发现。这些基因区域中的基因


英美等国研究人员的一项新研究首次确认了5个与偏头痛有关的基因区域,这将有助于科学家进一步了解偏头痛的病因,进而找到更好的治疗方法。

由英国、美国、澳大利亚等国研究人员组成的研究小组在《自然遗传学》杂志上发表论文称,他们完成了一项有史以来最大规模的偏头痛研究项目,通过对近12万个样本进行对比研究,最终确认了12个与偏头痛易感性有关的基因区域,其中5个基因区域为最新发现。这些基因区域中的基因,有的与大脑回路的调控有关,有的则负责维护脑细胞和组织正常运转。研究人员发现,这些基因区域中的基因是相互关联的,它们对于氧化应激反应十分敏感,会影响脑组织和细胞的内部调控机制,进而引发偏头痛。

参与此项研究的伦敦大学国王学院的莉迪亚·夸耶博士说:“这是有史以来最大规模的偏头痛遗传研究,科学家首次将研究目标瞄向偏头痛的遗传病因。通过对近12万个样本的研究,我们找到了与偏头痛相关的基因,并确认了一些偏头痛发生的机制。这项研究使我们对偏头痛这一病症有了更深的理解,也为未来开发更好的诊断和治疗手段带来了希望。”

偏头痛是一种十分折磨人的疾病,据估计,有七分之一的成年人会受到该种疾病的困扰。2010年的一项调查显示,在全球最重的几项疾病负担中,偏头痛名列第7位,同时也是治疗成本最高的一种神经障碍疾病。


Genome-wide meta-analysis identifies new susceptibility loci for migraine


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    2013-08-14 仁医06
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    2014-03-13 cy0324
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    2014-03-07 canlab
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    2014-01-02 huperzia

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